We designed this study to determine whether carvedilol, a β blocker that has hemodynamic
benefits
1
and decreases mortality,
- Bristow M.R.
- Gilbert E.M.
- Abraham W.T.
- Adams K.
- Fowler M.B.
- Hershberger R.E.
- Kubo S.H.
- Narahara M.D.
- Ingersoll H.
- Krueger S.
- Young S.
- Shusterman N.
MOCHA Investigators
Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure.
Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure.
Circulation. 1996; 94: 2807-2816
1
,
- Bristow M.R.
- Gilbert E.M.
- Abraham W.T.
- Adams K.
- Fowler M.B.
- Hershberger R.E.
- Kubo S.H.
- Narahara M.D.
- Ingersoll H.
- Krueger S.
- Young S.
- Shusterman N.
MOCHA Investigators
Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure.
Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure.
Circulation. 1996; 94: 2807-2816
2
improves baroreflex sensitivity and normalizes spectral components in patients with
advanced heart failure. To measure baroreflex sensitivity, we performed transfer function
analysis of RR variability, and compared the results with those yielded by the currently
acknowledged gold standard, the phenylephrine method.To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to American Journal of CardiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure.Circulation. 1996; 94: 2807-2816
- Clinical effects of beta-adrenergic blockade in chronic heart failure, a meta-analysis of double-blind placebo controlled, randomized trial.Circulation. 1998; 98: 1184-1191
- Arterial baroreflex modulation of heart rate in chronic heart failure, clinical and hemodynamic correlates and prognostic implications.Circulation. 1997; 96: 3450-3458
- Baroreflex sensitivity and heart rate variability in prediction of total cardiac mortality after myocardial infarction.Lancet. 1998; 351: 478-484
- Comparison between noninvasive indices of baroreceptor sensitivity and the phenylephrine method in post-myocardial infarction patients.Circulation. 1998; 97: 1362-1367
- Autonomic modulation of heart rate and blood pressure in hypertensive subjects with symptoms of anxiety.Clin Sci. 1998; 95: 43-52
Piccirillo G, Bucca C, Durante M, Santagada E, Munizzi MR, Cacciafesta M, Marigliano V. Heart rate and blood pressure variability in salt-sensitive hypertension. Hypertension 1996;28:6:944–952 .
- Age-dependent influence on heart rate variability in salt-sensitive hypertension subjects.J Am Geriatr Soc. 1996; 44: 530-538
- Autonomic modulation and QT interval dispersion in hypertensive subjects with anxiety.Hypertension. 1999; 34: 242-246
- Autonomic modulation of heart rate and blood pressure in normotensive offspring of hypertensive subjects.J Lab Clin Med. 2000; 135: 145-152
- Comparison of impedance cardiography with thermodilution and Fick methods for noninvasive measurement of stroke volume and cardiac output during incremental exercise in patients with ischemic cardiomyopathy.Am J Cardiol. 1996; 77: 1293-1301
- Abnormal awake respiratory patterns are common in chronic heart failure and may prevent evaluation of autonomic tone by measures of heart rate variability.Circulation. 1997; 96: 246-252
- Heart rate variability. Standard of measurements, physiological interpretation and clinical use.Circulation. 1996; 93: 1043-1065
- Can power spectral analysis of heart rate variability identify a high risk subgroup of congestive heart failure patients with excessive sympathetic activation? A pilot study before and after heart transplantation.Br Heart J. 1994; 71: 422-430
- Absence of low-frequency variability of sympathetic nerve activity in severe heart failure.Circulation. 1997; 95: 1449-1454
- Heart rate and blood pressure variability in obese normotensive subjects.Int J Obes. 1998; 22: 741-750
- Power spectral analysis of heart rate variability in obese subjects.Int J Obes. 1996; 20: 825-829
- Relationship between spectral components of cardiovascular variabilities and direct measures of muscle sympathetic nerve activity in humans.Circulation. 1997; 95: 1441-1448
- Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog.Circ Res. 1986; 59: 178-193
- Influence of neural mechanisms on heart period and arterial pressure variability in quadriplegic patients.Am J Physiol. 1994; 266: H1112-H1120
Article info
Publication history
Accepted:
June 23,
2000
Received in revised form:
June 23,
2000
Received:
April 3,
2000
Identification
Copyright
© 2000 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
