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Acute electrophysiologic effect of estradiol 17β in menopausal women

      Clinical studies have led to the suggestion that estrogen deficiency or estrogen-progestin imbalance may be associated with an increased incidence of cardiac arrhythmias such as those occurring during the luteal phase of the menstrual cycle, during oral contraceptive treatment, and during pregnancy and menopause.
      • Rosano G.M.C
      • Leonardo F
      • Sarrel P.M
      • Beale C.M
      • De Luca F
      • Collins P
      Cyclical variation in paroxysmal supraventricular tachycardia in women.
      ,
      • Rosano G.M.C
      • Rillo M
      • Leonardo F
      • Pappone C
      • Chierchia S.L
      Palpitations what is the mechanism and when should we treat them?.
      ,
      • Meller J
      • Goldman M.E
      Arrhythmias in pregnancy.
      In particular, menopause is associated with an increased incidence of palpitations, most of which are due to supraventricular arrhythmia. These palpitations may be partially related to the alteration of the autonomic nervous control of the cardiovascular system, and partially to the changes in the ovarian hormone profile, which occur with menopause. If the electophysiologic properties of estrogen shown in vitro are proved to occur also in vivo, then the lack of these hormones may be responsible, in part, for the palpitations reported during menopause. This study investigates whether the acute administration of estradiol 17β has an effect on the electrophysiology of the human heart in menopausal women.
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      References

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