Although the primary end point of many angiographic thrombolytic patency trials is
assessed at 90 minutes, injections are often performed before this standard time point.
The Thrombolysis In Myocardial Infarction (TIMI) Angiographic Core Laboratory uses
the first injection at each time point (60, 75, and 90 minutes) after thrombolytic
administration to assess the TIMI flow grade and the corrected TIMI frame count (CTFC).
Whereas the coronary arteriogram is conventionally viewed as “diagnostic,” the frequency
with which this first injection might be “therapeutic” and contribute to the mechanical
opening of occluded coronary arteries is not well defined. We hypothesized that mechanical
opening is infrequent, and we studied 4,021 consecutive first injections (815 that
were occluded) in the TIMI 10B and 14 trials to define its frequency and to determine
the potential impact that injections have on patency rates in thrombolytic trials.
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Article Info
Publication History
Accepted:
June 21,
2000
Received in revised form:
June 21,
2000
Received:
February 24,
2000
Footnotes
☆This report was supported in part by a grant from Genentech, Inc., South San Francisco, California; Boehringer Ingelheim, Ingelheim, Germany (TIMI 10B); Centocor and Eli Lilly Inc., Malvern, Pennsylvania, and Indianapolis, Indiana (TIMI 14).
Identification
Copyright
© 2000 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
