In the setting of acute coronary syndromes, flow in nonculprit arteries has not been
studied widely, in part because it has been assumed to be normal.
1
We have recently demonstrated that the corrected Thrombolysis In Myocardial Infarction
(TIMI) frame count (CTFC) in the nonculprit artery is not normal in the setting of
acute myocardial infarction, but returns to normal within 1 day after thrombolysis.
2
,
3
,
4
,
5
The goals of this study were to assess the relation between culprit and nonculprit
artery flows in acute coronary syndromes and to determine if percutaneous transluminal
coronary angioplasty (PTCA) and/or directional coronary atherectomy (DCA) of the culprit
artery improves flow in the nonculprit artery.To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to American Journal of CardiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- The Thrombolysis in Myocardial Infarction (TIMI) trial. Phase I finding.N Engl J Med. 1985; 312: 932-936
- The TIMI frame count.Circulation. 1996; 93: 879-888
- The relationship between the TIMI Frame Count and clinical outcomes after thrombolytic administration.Circulation. 1999; 99: 1945-1950
- Impaired coronary blood flow in non-culprit arteries in the setting of acute myocardial infarction.J Am Coll Cardiol. 1999; 34: 974-982
- Determinants of coronary blood flow following thrombolytic administration.J Am Coll Cardiol. 1999; 34: 1403-1412
- The effects of platelet glycoprotein IIb/IIIa blockade with tirofiban on adverse cardiac events in patients with unstable angina or acute myocardial infarction undergoing coronary angioplasty.Circulation. 1997; 96: 1445-1453
- Six month angiographic and clinical outcomes following IIb/IIIa blockade with tirofiban.J Am Coll Cardiol. 1998; 32: 28-34
StataCorp 1997. Stata Statistical Software: Release 5.0. College Station, TX: Stata Corporation.
- Reduced coronary vasodilator function in infarcted and normal myocardium after myocardial infarction.N Engl J Med. 1994; 331: 222-227
- PET perfusion and vasodilator function after angioplasty for acute myocardial infarction.J Nucl Med. 1997; 38: 770-777
- Functional abnormalities in non-occluded regions of myocardium after experimental coronary occlusion.Am J Cardiol. 1976; 37: 366-372
- Consequences of coronary arterial occlusion on remote myocardium.Am J Cardiol. 1975; 36: 385-392
- α-Adrenergic blockade improves recovery of myocardial perfusion and function after coronary stenting in patients with acute myocardial infarction.Circulation. 1999; 99: 482-490
Article info
Publication history
Accepted:
June 27,
2000
Received in revised form:
June 27,
2000
Received:
April 5,
2000
Identification
Copyright
© 2000 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.