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Short communication| Volume 86, ISSUE 12, P1375-1377, December 15, 2000

Global impairment of coronary blood flow in the setting of acute coronary syndromes (a RESTORE substudy)1

DOI:https://doi.org/10.1016/S0002-9149(00)01247-9
Global impairment of coronary blood flow in the setting of acute coronary syndromes (a RESTORE substudy)11The principal investigators of the RESTORE (Randomized Efficacy Study of Tirofiban for Outcomes and Restenosis) trial and their associations are listed in the appendix of The RESTORE Investigators.6
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      In the setting of acute coronary syndromes, flow in nonculprit arteries has not been studied widely, in part because it has been assumed to be normal.
      TIMI Study Group
      The Thrombolysis in Myocardial Infarction (TIMI) trial. Phase I finding.
      N Engl J Med. 1985; 312: 932-936
      We have recently demonstrated that the corrected Thrombolysis In Myocardial Infarction (TIMI) frame count (CTFC) in the nonculprit artery is not normal in the setting of acute myocardial infarction, but returns to normal within 1 day after thrombolysis.
      • Gibson C.M.
      • Cannon C.P.
      • Daley W.L.
      • Dodge J.T.
      • Alexander B.
      • Marble S.J.
      • McCabe C.H.
      • Raymond L.
      • Fortin T.
      • Poole W.K.
      • Braunwald E.
      The TIMI frame count a quantitative method of assessing coronary artery flow.
      Circulation. 1996; 93: 879-888
      ,
      • Gibson C.M.
      • Murphy S.A.
      • Rizzo M.J.
      • Ryan K.A.
      • Marble S.J.
      • McCabe C.H.
      • Cannon C.P.
      • Van de Werf F.
      • Braunwald E.
      The relationship between the TIMI Frame Count and clinical outcomes after thrombolytic administration.
      Circulation. 1999; 99: 1945-1950
      ,
      • Gibson C.M.
      • Ryan K.A.
      • Murphy S.A.
      • Mesley R.
      • Marble S.J.
      • Guigliano R.P.
      • Cannon C.P.
      • Antman E.M.
      • Braunwald E.
      Impaired coronary blood flow in non-culprit arteries in the setting of acute myocardial infarction.
      J Am Coll Cardiol. 1999; 34: 974-982
      ,
      • Gibson C.M.
      • Murphy S.A.
      • Menown I.
      • Sequeira R.F.
      • Greene R.
      • Van de Werf F.
      • Schweiger M.J.
      • Ghali M.
      • Frey M.
      • Ryan K.A.
      • et al.
      TIMI Study Group
      Determinants of coronary blood flow following thrombolytic administration.
      J Am Coll Cardiol. 1999; 34: 1403-1412
      The goals of this study were to assess the relation between culprit and nonculprit artery flows in acute coronary syndromes and to determine if percutaneous transluminal coronary angioplasty (PTCA) and/or directional coronary atherectomy (DCA) of the culprit artery improves flow in the nonculprit artery.
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      References

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        The Thrombolysis in Myocardial Infarction (TIMI) trial. Phase I finding.
        N Engl J Med. 1985; 312: 932-936
        View in Article
        • Gibson C.M.
        • Cannon C.P.
        • Daley W.L.
        • Dodge J.T.
        • Alexander B.
        • Marble S.J.
        • McCabe C.H.
        • Raymond L.
        • Fortin T.
        • Poole W.K.
        • Braunwald E.
        The TIMI frame count.
        Circulation. 1996; 93: 879-888
        View in Article
        • Gibson C.M.
        • Murphy S.A.
        • Rizzo M.J.
        • Ryan K.A.
        • Marble S.J.
        • McCabe C.H.
        • Cannon C.P.
        • Van de Werf F.
        • Braunwald E.
        The relationship between the TIMI Frame Count and clinical outcomes after thrombolytic administration.
        Circulation. 1999; 99: 1945-1950
        View in Article
        • Gibson C.M.
        • Ryan K.A.
        • Murphy S.A.
        • Mesley R.
        • Marble S.J.
        • Guigliano R.P.
        • Cannon C.P.
        • Antman E.M.
        • Braunwald E.
        Impaired coronary blood flow in non-culprit arteries in the setting of acute myocardial infarction.
        J Am Coll Cardiol. 1999; 34: 974-982
        View in Article
        • Gibson C.M.
        • Murphy S.A.
        • Menown I.
        • Sequeira R.F.
        • Greene R.
        • Van de Werf F.
        • Schweiger M.J.
        • Ghali M.
        • Frey M.
        • Ryan K.A.
        • et al.
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        J Am Coll Cardiol. 1999; 34: 1403-1412
        View in Article
        • RESTORE Investigators
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      Article Info

      Publication History

      Accepted: June 27, 2000
      Received in revised form: June 27, 2000
      Received: April 5, 2000

      Identification

      DOI: https://doi.org/10.1016/S0002-9149(00)01247-9

      Copyright

      © 2000 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.

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