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Global impairment of coronary blood flow in the setting of acute coronary syndromes (a RESTORE substudy)1

      In the setting of acute coronary syndromes, flow in nonculprit arteries has not been studied widely, in part because it has been assumed to be normal.
      TIMI Study Group
      The Thrombolysis in Myocardial Infarction (TIMI) trial. Phase I finding.
      We have recently demonstrated that the corrected Thrombolysis In Myocardial Infarction (TIMI) frame count (CTFC) in the nonculprit artery is not normal in the setting of acute myocardial infarction, but returns to normal within 1 day after thrombolysis.
      • Gibson C.M.
      • Cannon C.P.
      • Daley W.L.
      • Dodge J.T.
      • Alexander B.
      • Marble S.J.
      • McCabe C.H.
      • Raymond L.
      • Fortin T.
      • Poole W.K.
      • Braunwald E.
      The TIMI frame count a quantitative method of assessing coronary artery flow.
      ,
      • Gibson C.M.
      • Murphy S.A.
      • Rizzo M.J.
      • Ryan K.A.
      • Marble S.J.
      • McCabe C.H.
      • Cannon C.P.
      • Van de Werf F.
      • Braunwald E.
      The relationship between the TIMI Frame Count and clinical outcomes after thrombolytic administration.
      ,
      • Gibson C.M.
      • Ryan K.A.
      • Murphy S.A.
      • Mesley R.
      • Marble S.J.
      • Guigliano R.P.
      • Cannon C.P.
      • Antman E.M.
      • Braunwald E.
      Impaired coronary blood flow in non-culprit arteries in the setting of acute myocardial infarction.
      ,
      • Gibson C.M.
      • Murphy S.A.
      • Menown I.
      • Sequeira R.F.
      • Greene R.
      • Van de Werf F.
      • Schweiger M.J.
      • Ghali M.
      • Frey M.
      • Ryan K.A.
      • et al.
      TIMI Study Group
      Determinants of coronary blood flow following thrombolytic administration.
      The goals of this study were to assess the relation between culprit and nonculprit artery flows in acute coronary syndromes and to determine if percutaneous transluminal coronary angioplasty (PTCA) and/or directional coronary atherectomy (DCA) of the culprit artery improves flow in the nonculprit artery.
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