Low fibrinolytic activity and high levels of coagulation markers are related to the
incidence of ischemic cardiovascular disease, reinfarction, and thromboembolic events.
1
,
2
,
3
Acute physical exercise is a potent stimulator of fibrinolysis and coagulation.
4
,
5
,
6
,
7
The ability to increase fibrinolytic activity and maintain hemostatic balance in
response to maximal exercise is often used to detect abnormalities that are not necessarily
evident at rest
6
and may be predictive of future cardiovascular events.
8
Beta blockers prevent reinfarction and are effective for treatment of hypertension
and angina.
9
Their influence on hemostasis is unclear and timolol has been related to an increased
occurrence of left ventricular thrombi in patients with acute myocardial infarction.
10
Only a few studies have evaluated the effect of β blockade on fibrinolysis during
exercise,
11
and have shown inconsistent results. During exercise, no studies have evaluated the
effect of selective and nonselective β blockade on fibrinolytic activity, with simultaneous
measurements of in vivo markers of coagulation activation. Measures of fibrinolysis
and coagulation activation are needed to obtain a more complete picture of hemostatic
balance. The purpose of this study was to evaluate the effect of propranolol and atenolol
on fibrinolytic markers and coagulation activation at rest and after maximal exercise
using a randomized, double-blind crossover design.To read this article in full you will need to make a payment
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Article Info
Publication History
Accepted:
June 29,
2000
Received in revised form:
June 29,
2000
Received:
January 17,
2000
Identification
Copyright
© 2000 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
