Low fibrinolytic activity and high levels of coagulation markers are related to the
incidence of ischemic cardiovascular disease, reinfarction, and thromboembolic events.
1
,
2
,
3
Acute physical exercise is a potent stimulator of fibrinolysis and coagulation.
4
,
5
,
6
,
7
The ability to increase fibrinolytic activity and maintain hemostatic balance in
response to maximal exercise is often used to detect abnormalities that are not necessarily
evident at rest
6
and may be predictive of future cardiovascular events.
8
Beta blockers prevent reinfarction and are effective for treatment of hypertension
and angina.
9
Their influence on hemostasis is unclear and timolol has been related to an increased
occurrence of left ventricular thrombi in patients with acute myocardial infarction.
10
Only a few studies have evaluated the effect of β blockade on fibrinolysis during
exercise,
11
and have shown inconsistent results. During exercise, no studies have evaluated the
effect of selective and nonselective β blockade on fibrinolytic activity, with simultaneous
measurements of in vivo markers of coagulation activation. Measures of fibrinolysis
and coagulation activation are needed to obtain a more complete picture of hemostatic
balance. The purpose of this study was to evaluate the effect of propranolol and atenolol
on fibrinolytic markers and coagulation activation at rest and after maximal exercise
using a randomized, double-blind crossover design.To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to American Journal of CardiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Fibrinolytic activity, clotting factors, and long term incidence of ischaemic heart disease in the Northwick Park Heart Study.Lancet. 1993; 342: 1076-1079
- Plasminogen activator inhibitor in plasma.Lancet. 1987; 4: 3-9
- Prothrombin activation fragment 1+2 and thrombin antithrombin III complexes in patients with angina pectoris.Thromb Haemost. 1993; 70: 550-553
- Fibrinolytic activity is similar in physically active men with and without a history of myocardial infarction.Arterioscler Thromb Vasc Biol. 1997; 17: 1106-1113
- Fibrinolytic activity is not dependent upon exercise mode in post-myocardial infarction patients.Eur J Appl Physiol. 1998; 78: 247-252
- Effects of maximal exercise and venous occlusion on fibrinolytic activity in physically active and inactive men.J Appl Physiol. 1994; 77: 2305-2310
- Fibrinolytic responses to moderate intensity exercise.Arterscler Thromb. 1994; 14: 1746-1750
- Fibrinolytic variables and cardiovascular prognosis in patients with stable angina pectoris treated with verapamil or metropolol.Circulation. 1997; 95: 2380-2386
- A randomized trial of propanolol in patients with acute myocardial infarction.JAMA. 1982; 247: 1707-1713
- Increased occurrence of left ventricular thrombi during early treatment with timolol in patients with acute myocardial infarction.Circulation. 1987; 75: 151-155
- Extrinsic plasminogen activator response to exercise after a single dose of propanolol.Med Sci Sports Exerc. 1992; 24: 327-332
- Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration.J Appl Physiol. 1974; 37: 247-248
- Plasma catecholamine and ventilatory responses to cycling after propranolol treatment.Med Sci Sports Exerc. 1995; 27: 1616-1620
- Fibrinogen and plasminogen activator inhibitor-1 levels in hypertension and coronary artery disease.Circulation. 1991; 84: VI72-VI77
- Influence of metoprolol treatment on sympatho-adrenal activation of fibrinolysis.Thromb Heamost. 1990; 63: 482-487
- The circulatory regulation of TPA and UPA secretion, clearance, and inhibition during exercise and during infusion of isoproterenol and phenylephedrine.Circulation. 1995; 92: 2984-2994
- The effect of propanolol, alpenolol, and practolol on the fibrinolytic and factor VIII responses to adrenaline and salbutamol in man.Thromb Res. 1974; 4: 25-33
- A comparison of the blood lactate and plasma catecholamine thresholds in untrained male subjects.Int J Sports Med. 1992; 13: 563-566
- Coagulation and fibrinolysis after moderate and very heavy exercise in healthy male subjects.Med Sci Sports Exerc. 1998; 30: 246-251
Article info
Publication history
Accepted:
June 29,
2000
Received in revised form:
June 29,
2000
Received:
January 17,
2000
Identification
Copyright
© 2000 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
