Advertisement
The American Journal of Cardiology®
Advanced searchSave search
Brief report| Volume 86, ISSUE 11, P1279-1281, December 01, 2000

Sequential evaluation of left ventricular myocardial performance in children after anthracycline therapy

Published:August 16, 2004DOI:https://doi.org/10.1016/S0002-9149(00)01222-4
Sequential evaluation of left ventricular myocardial performance in children after anthracycline therapy
Previous ArticleImpact of low body weight on frequency of pediatric cardiac catheterization complications
Next ArticleIncidence and clinical significance of bacteremia and sepsis among cardiac patients treated with intra-aortic balloon counterpulsation pump
      The anthracycline antibiotics are important components of many antineoplastic chemotherapeutic regimens. The sequential monitoring of cardiac function of patients undergoing chemotherapy allows the identification of subclinical cardiotoxicity. Such cardiotoxicity is related to the cumulative dose of these drugs; the risk of congestive heart failure in children has been reported to increase at cumulative doses of >550 mg per body surface area.
      • Steinherz L.J.
      • Graham T.
      • Hurwitz R.
      • Sondheimer H.M.
      • Schwartz R.G.
      • Shaffer E.M.
      • Sandor G.
      • Benson L.
      • Williams R.
      Guidelines for cardiac monitoring of children during and after anthracycline therapy report of the cardiology committee of the childrens’ cancer study group.
      Pediatrics. 1992; 89: 942-949
      ,
      • Shan K.
      • Lincoff M.
      • Young J.B.
      Anthracycline-induced cardiotoxicity.
      Ann Intern Med. 1996; 125: 47-58
      To our knowledge, little has been published on the effects of moderate doses of anthracycline antibiotics on left ventricular myocardial performance in clinically asymptomatic children treated for malignant neoplasms. Recently, an easily measured new Doppler index of left ventricular myocardial performance that combines systolic and diastolic time intervals known as the Tei index was proposed.
      • Tei C.
      New non-invasive index for combined systolic and diastolic ventricular function.
      J Cardiol. 1995; 26: 135-136
      ,
      • Tei C.
      • Ling L.H.
      • Hodge D.O.
      • Bailey K.R.
      • Oh J.K.
      • Rodeheffer R.J.
      • Tajik A.J.
      • Seward J.B.
      New index of combined systolic and diastolic myocardial performance a simple and reproducible measure of cardiac function—a study in normal and dilated cardiomyopathy.
      J Cardiol. 1995; 26: 357-366
      This index allows assessment of cardiac “reserve” and enables earlier detection of myocardial dysfunction. It has previously been correlated with severity and clinical outcome in adult
      • Tei C.
      New non-invasive index for combined systolic and diastolic ventricular function.
      J Cardiol. 1995; 26: 135-136
      ,
      • Tei C.
      • Ling L.H.
      • Hodge D.O.
      • Bailey K.R.
      • Oh J.K.
      • Rodeheffer R.J.
      • Tajik A.J.
      • Seward J.B.
      New index of combined systolic and diastolic myocardial performance a simple and reproducible measure of cardiac function—a study in normal and dilated cardiomyopathy.
      J Cardiol. 1995; 26: 357-366
      ,
      • Tei C.
      • Dujardin K.S.
      • Hodge D.O.
      • Kyle R.A.
      • Tajik A.J.
      • Seward J.B.
      Doppler index combining systolic and diastolic myocardial performance clinical value in cardiac amyloidosis.
      J Am Coll Cardiol. 1996; 28: 658-664
      and pediatric patients with congenital or acquired heart disease.
      • Eidem B.W.
      • Tei C.
      • O’Leary P.W.
      • Cetta F.
      • Seward J.B.
      Nongeometric quantitative assessment of right and left ventricular function myocardial performance index in normal children and patients with Ebstein anomaly.
      J Am Soc Echocardiogr. 1998; 11: 849-856
      ,
      • Eto G.
      • Ishii M.
      • Tei C.
      • Tsutsumi T.
      • Akagi T.
      • Kato H.
      Assessment of global left ventricular function in normal children and dilated cardiomyopathy.
      J Am Soc Echocardiogr. 1999; 12: 1058-1064
      ,
      • Tsutsumi T.
      • Ishii M.
      • Eto G.
      • Hota M.
      • Kato H.
      Serial evaluation for myocardial performance in fetuses and neonates using a new Doppler index.
      Pediatr Int. 1999; 41: 722-727
      ,
      • Ishii M.
      • Eto G.
      • Tei C.
      • Tsutsumi T.
      • Hashino K.
      • Sugahara Y.
      • Himeno W.
      • Muta H.
      • Furui J.
      • Akagi T.
      • Fukiyama R.
      • Toyoda O.
      • Kato H.
      Quantitation of the global right ventricular function in children with normal heart and congenital heart disease a right ventricular myocardial performance index.
      Pediatr Cardiol. 2000; 21: 416-421
      This study prospectively evaluated the Tei index for detecting subclinical cardiotoxicity in patients undergoing chemotherapy.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to American Journal of Cardiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Steinherz L.J.
        • Graham T.
        • Hurwitz R.
        • Sondheimer H.M.
        • Schwartz R.G.
        • Shaffer E.M.
        • Sandor G.
        • Benson L.
        • Williams R.
        Guidelines for cardiac monitoring of children during and after anthracycline therapy.
        Pediatrics. 1992; 89: 942-949
        View in Article
        • Shan K.
        • Lincoff M.
        • Young J.B.
        Anthracycline-induced cardiotoxicity.
        Ann Intern Med. 1996; 125: 47-58
        View in Article
        • Tei C.
        New non-invasive index for combined systolic and diastolic ventricular function.
        J Cardiol. 1995; 26: 135-136
        View in Article
        • Tei C.
        • Ling L.H.
        • Hodge D.O.
        • Bailey K.R.
        • Oh J.K.
        • Rodeheffer R.J.
        • Tajik A.J.
        • Seward J.B.
        New index of combined systolic and diastolic myocardial performance.
        J Cardiol. 1995; 26: 357-366
        View in Article
        • Tei C.
        • Dujardin K.S.
        • Hodge D.O.
        • Kyle R.A.
        • Tajik A.J.
        • Seward J.B.
        Doppler index combining systolic and diastolic myocardial performance.
        J Am Coll Cardiol. 1996; 28: 658-664
        View in Article
        • Eidem B.W.
        • Tei C.
        • O’Leary P.W.
        • Cetta F.
        • Seward J.B.
        Nongeometric quantitative assessment of right and left ventricular function.
        J Am Soc Echocardiogr. 1998; 11: 849-856
        View in Article
        • Eto G.
        • Ishii M.
        • Tei C.
        • Tsutsumi T.
        • Akagi T.
        • Kato H.
        Assessment of global left ventricular function in normal children and dilated cardiomyopathy.
        J Am Soc Echocardiogr. 1999; 12: 1058-1064
        View in Article
        • Tsutsumi T.
        • Ishii M.
        • Eto G.
        • Hota M.
        • Kato H.
        Serial evaluation for myocardial performance in fetuses and neonates using a new Doppler index.
        Pediatr Int. 1999; 41: 722-727
        View in Article
        • Ishii M.
        • Eto G.
        • Tei C.
        • Tsutsumi T.
        • Hashino K.
        • Sugahara Y.
        • Himeno W.
        • Muta H.
        • Furui J.
        • Akagi T.
        • Fukiyama R.
        • Toyoda O.
        • Kato H.
        Quantitation of the global right ventricular function in children with normal heart and congenital heart disease.
        Pediatr Cardiol. 2000; 21: 416-421
        View in Article
        • Hashimoto I.
        • Ichida F.
        • Miura M.
        • Okabe T.
        • Kanegane H.
        • Uese K.
        • Hamamichi Y.
        • Misaki T.
        • Koizumi S.
        • Miyawaki T.
        Automatic border detection identifies subclinical Anthracycline cardiotoxicity in children with malignancy.
        Circulation. 1999; 99: 2367-2370
        View in Article
        • Wolk M.J.
        • Keefe J.F.
        • Bing O.H.L.
        • Finkelstein L.J.
        • Levine H.J.
        Estimation of V maxiauxotonic systoles from the rate of relative increase of isovolumic pressure.
        J Clin Invest. 1971; 50: 1276-1285
        View in Article
        • Papapietro S.E.
        • Coghlan H.C.
        • Zissermann D.
        • Russell Jr, R.O.
        • Rackley C.E.
        • Roger W.J.
        Impaired maximal rate of left ventricular relaxation in patients with coronary artery disease and left ventricular dysfunction.
        Circulation. 1979; 59: 984-991
        View in Article
        • Weissler A.M.
        The heart in heart failure.
        Ann Intern Med. 1968; 69: 929-940
        View in Article

      Article info

      Publication history

      Published online: August 16, 2004
      Accepted: June 19, 2000
      Received in revised form: June 19, 2000
      Received: April 18, 2000

      Identification

      DOI: https://doi.org/10.1016/S0002-9149(00)01222-4

      Copyright

      © 2000 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.

      ScienceDirect

      Access this article on ScienceDirect
      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX