Advertisement

Intravenous magnesium sulfate for acute termination of sustained monomorphic ventricular tachycardia associated with coronary artery disease

      Intravenous magnesium (Mg) is often recommended for the emergency management of selected arrhythmias.
      • Frakes M.A.
      • Richardson L.E.
      Magnesium sulfate therapy in certain emergency conditions.
      It has an established place in the treatment of drug-induced torsades de pointes ventricular tachycardia (VT) and digoxin-induced tachyarrhythmias.
      • Fazekas T.
      • Scherlag B.J.
      • Vos M.
      • Wellens H.J.J.
      • Lazzara R.
      Magnesium and the heart antiarrhythmic therapy with magnesium.
      In contrast, there are limited data regarding the efficacy of intravenous Mg in terminating the more common sustained monomorphic VT. Previous small series have indicated that intravenous Mg can abort sustained monomorphic VT in experimental animals
      • Harris A.S.
      • Estandia A.
      • Smith H.T.
      • Olsen R.W.
      • Ford T.J.
      • Tillotson R.F.
      Magnesium sulfate and chloride in suppression of ectopic ventricular tachycardia accompanying acute myocardial infarction.
      and humans.
      • Allen B.J.
      • Brodsky M.A.
      • Capparelli E.V.
      • Luckett C.R.
      • Iseri L.T.
      Magnesium sulfate therapy for sustained monomorphic ventricular tachycardia.
      ,

      Brooks R, McGovern BA, Chernow B, Garan H, Ruskin JN. Suppression of monomorphic ventricular tachycardia by intravenous magnesium chloride predicts the effectiveness of oral calcium channel blocker therapy. Circulation 1990;82(suppl III):III–82A.

      The primary aim of this study was to determine the efficacy of intravenous Mg in terminating sustained monomorphic VT induced by programmed electrical stimulation in the electrophysiology laboratory. Furthermore, the effect of Mg on VT characteristics, cardiac electrophysiologic parameters, and its ability to prevent reinduction of VT was assessed.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to American Journal of Cardiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Frakes M.A.
        • Richardson L.E.
        Magnesium sulfate therapy in certain emergency conditions.
        Am J Emerg Med. 1997; 15: 182-187
        • Fazekas T.
        • Scherlag B.J.
        • Vos M.
        • Wellens H.J.J.
        • Lazzara R.
        Magnesium and the heart.
        Clin Cardiol. 1993; 16: 768-774
        • Harris A.S.
        • Estandia A.
        • Smith H.T.
        • Olsen R.W.
        • Ford T.J.
        • Tillotson R.F.
        Magnesium sulfate and chloride in suppression of ectopic ventricular tachycardia accompanying acute myocardial infarction.
        Am J Physiol. 1953; 172: 251-258
        • Allen B.J.
        • Brodsky M.A.
        • Capparelli E.V.
        • Luckett C.R.
        • Iseri L.T.
        Magnesium sulfate therapy for sustained monomorphic ventricular tachycardia.
        Am J Cardiol. 1989; 64: 1202-1204
      1. Brooks R, McGovern BA, Chernow B, Garan H, Ruskin JN. Suppression of monomorphic ventricular tachycardia by intravenous magnesium chloride predicts the effectiveness of oral calcium channel blocker therapy. Circulation 1990;82(suppl III):III–82A.

        • Tzivoni D.
        • Banai S.
        • Schuger C.
        • Benhorin J.
        • Keren A.
        • Gottlieb S.
        • Stern S.
        Treatment of torsade de pointes with magnesium sulfate.
        Circulation. 1988; 77: 392-397