Neurohumoral excitatory state results from abnormality of baroreflexes and reduced
tonic restraint of baroreflexes leads to neurohumoral excitation.
1
The cardiopulmonary baroreflexes originate mainly from the heart
- Abboud F.M.
- Thames M.D.
- Mark A.L.
Role of cardiac afferent nerves in regulation of circulation during coronary occlusion
and heart failure.
in: Abboud F.M. Fozzard H.A. Gilmore J.P. Reis D.J. Disturbances in Neurogenic Control of the Circulation. American Physiological Society,
Bethesda, MD1981: 65-86
2
and modulate systemic vascular resistance, plasma catecholamines, and plasma renin
activity.
3
,
4
Previous studies have reported that cardiopulmonary baroreflexes are depressed after
acute myocardial infarction (AMI) and improve gradually from the initial impairment.
5
,
6
Angiotensin-converting enzyme (ACE) inhibitors improve survival of AMI
7
,
8
and have been shown to modify cardiopulmonary baroreflexes in patients with congestive
heart failure.
9
However, the effect of ACE inhibitors on cardiopulmonary baroreflexes in patients
with AMI is yet to be determined. Therefore, the present study was performed to evaluate
the effect of the ACE inhibitor quinapril on cardiopulmonary baroreflexes in patients
with AMI.To read this article in full you will need to make a payment
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References
- Role of cardiac afferent nerves in regulation of circulation during coronary occlusion and heart failure.in: Abboud F.M. Fozzard H.A. Gilmore J.P. Reis D.J. Disturbances in Neurogenic Control of the Circulation. American Physiological Society, Bethesda, MD1981: 65-86
- Cardiopulmonary receptor regulation of renin release.Am J Med. 1988; 84: 97-104
- Carotid and cardiopulmonary baroreceptor control of splanchnic and forearm vasoconstrictor resistance during venous pooling in man.J Physiol (Lond). 1979; 286: 173-184
- Changes in plasma catecholamines in response to reflex modulation of sympathetic vasoconstrictor tone by cardiopulmonary receptors.Clin Sci. 1985; 68: 503-510
- Cardiopulmonary baroreflexes in humans.in: Shepherd J.T. Abboud F.M. Handbook of physiology, The Cardiovascular System. vol III. Part 2. American Physiological Society, Bethesda, MD1983: 795-814
- Cardiopulmonary receptor and arterial baroreceptor reflexes after acute myocardial infarction.Am J Cardiol. 1992; 69: 873-878
- Effects of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure.Lancet. 1993; 432: 821-828
- GISSI-3.Lancet. 1994; 343: 1115-1122
- Enalaprilat augments arterial and cardiopulmonary baroreflex control of sympathetic nerve activity in patients with heart failure.J Am Coll Cardiol. 1996; 27: 358-364
- An electrically calibrated plethysmograph for direct measurement of limb blood flow.IEEE Trans Biomed Eng. 1975; 22: 21-25
- Liquid chromatogaraphic analysis of catecholamines.Life Sci. 1976; 19: 995-1004
- Influence of sodium hemostasis on dopamine modulation of aldosterone renin and prolactin in man.J Clin Endocrinol Metab. 1982; 54: 121-126
- Control of sympathetic nerve activity by vagal mechanoreflexes is blunted in heart failure.Circulation. 1992; 86: 1929-1934
- Interactions between ANG II, sympathetic nervous system, and baroreceptor reflexes in regulation of blood pressure.Am J Physiol. 1992; 262: E763-E778
- Different effect of vasopressin and angiotensin II on baroreflexes.Fed Proc. 1985; 44: 2388-2392
- Central attenuation of baroreflex by angiotensin II in normotensive and spontaneously hypertensive rats.Am J Hypertens. 1988; 1: 15S-22S
- Evidence that the area postrema mediates the central cardiovascular response to angiotensin II.Nature. 1970; 228: 1301-1304
- Centrally infused bradykinin increases baroreceptor reflex sensitivity.Hypertension. 1992; 19: II-176-II-181
- Clinical and hemodynamic correlates of sympathetic nerve activity in normal humans and patients with heart failure.J Am Coll Cardiol. 1990; 16: 1125-1134
- Muscle sympathetic activity and plasma noradrenaline in normotensive and hypertensive man.Acta Physiol Scand. 1983; 119: 117-121
Article info
Publication history
Published online: August 16, 2004
Accepted:
June 9,
2000
Received in revised form:
June 9,
2000
Received:
March 16,
2000
Footnotes
☆This work was supported by Yoshitomi Pharmaceutical Industries, Tokyo, Japan.
Identification
Copyright
© 2000 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.