Advertisement

Incidence, Predictors, and Outcomes of Thrombotic Events in Hospitalized Patients With Viral Pneumonia

Published:January 13, 2021DOI:https://doi.org/10.1016/j.amjcard.2021.01.001
      Viral pneumonia represents a major cause of morbidity and mortality, especially among older patients.
      • Thompson WW
      • Shay DK
      • Weintraub E
      • Brammer L
      • Cox N
      • Anderson LJ
      • Fukuda K.
      Mortality associated with influenza and respiratory syncytial virus in the United States.
      Viral pneumonia may be associated with a systemic inflammatory response, which has been linked with arterial and venous thrombotic cardiovascular events.
      • Smeeth L
      • Thomas SL
      • Hall AJ
      • Hubbard R
      • Farrington P
      • Vallance P.
      Risk of myocardial infarction and stroke after acute infection or vaccination.
      During the recent COVID-19 pandemic due to the novel SARS-CoV-2 virus, anecdotal and published experience suggests high rates of thrombotic complications among hospitalized patients.
      • Bikdeli B
      • Madhavan MV
      • Jimenez D
      • Chuich T
      • Dreyfus I
      • Driggin E
      • Nigoghossian C
      • Ageno W
      • Madjid M
      • Guo Y
      • Tang LV
      • Hu Y
      • Giri J
      • Cushman M
      • Quéré I
      • Dimakakos EP
      • Gibson CM
      • Lippi G
      • Favaloro EJ
      • Fareed J
      • Caprini JA
      • Tafur AJ
      • Burton JR
      • Francese DP
      • Wang EY
      • Falanga A
      • McLintock C
      • Hunt BJ
      • Spyropoulos AC
      • Barnes GD
      • Eikelboom JW
      • Weinberg I
      • Schulman S
      • Carrier M
      • Piazza G
      • Beckman JA
      • Steg PG
      • Stone GW
      • Rosenkranz S
      • Goldhaber SZ
      • Parikh SA
      • Monreal M
      • Krumholz HM
      • Konstantinides SV
      • Weitz JI
      • Lip GYH.
      COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up: JACC State-of-the-Art Review.
      Due to a paucity of studies describing the incidence, predictors, and outcomes of thrombotic events among patients with viral pneumonia, the observation of thrombosis in patients with COVID-19 lacks context. Hence, we aimed to address this knowledge gap using a large nationally representative dataset.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to American Journal of Cardiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Thompson WW
        • Shay DK
        • Weintraub E
        • Brammer L
        • Cox N
        • Anderson LJ
        • Fukuda K.
        Mortality associated with influenza and respiratory syncytial virus in the United States.
        JAMA. 2003; 289: 179-186
        • Smeeth L
        • Thomas SL
        • Hall AJ
        • Hubbard R
        • Farrington P
        • Vallance P.
        Risk of myocardial infarction and stroke after acute infection or vaccination.
        N Engl J Med. 2004; 351: 2611-2618
        • Bikdeli B
        • Madhavan MV
        • Jimenez D
        • Chuich T
        • Dreyfus I
        • Driggin E
        • Nigoghossian C
        • Ageno W
        • Madjid M
        • Guo Y
        • Tang LV
        • Hu Y
        • Giri J
        • Cushman M
        • Quéré I
        • Dimakakos EP
        • Gibson CM
        • Lippi G
        • Favaloro EJ
        • Fareed J
        • Caprini JA
        • Tafur AJ
        • Burton JR
        • Francese DP
        • Wang EY
        • Falanga A
        • McLintock C
        • Hunt BJ
        • Spyropoulos AC
        • Barnes GD
        • Eikelboom JW
        • Weinberg I
        • Schulman S
        • Carrier M
        • Piazza G
        • Beckman JA
        • Steg PG
        • Stone GW
        • Rosenkranz S
        • Goldhaber SZ
        • Parikh SA
        • Monreal M
        • Krumholz HM
        • Konstantinides SV
        • Weitz JI
        • Lip GYH.
        COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up: JACC State-of-the-Art Review.
        J Am Coll Cardiol. 2020; 75: 2950-2973
        • Tripathi B
        • Kumar V
        • Kalra A
        • Gupta T
        • Sawant AC
        • Sharma P
        • Arora S
        • Panhwar MS
        • Gopalan R
        • Deshmukh A
        • Pershad A
        • Gulati M
        • Bhatt DL.
        Influence of influenza infection on in-hospital acute myocardial infarction outcomes.
        Am J Cardiol. 2020; 130: 7-14