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Autonomic Findings in Takotsubo Cardiomyopathy

Published:November 05, 2015DOI:https://doi.org/10.1016/j.amjcard.2015.10.028
      Takotsubo cardiomyopathy (TC) often occurs after emotional or physical stress. Norepinephrine levels are unusually high in the acute phase, suggesting a hyperadrenergic mechanism. Comparatively little is known about parasympathetic function in patients with TC. We sought to characterize autonomic function at rest and in response to physical and emotional stimuli in 10 women with a confirmed history of TC and 10 age-matched healthy women. Sympathetic and parasympathetic activity was assessed at rest and during baroreflex stimulation (Valsalva maneuver and tilt testing), cognitive stimulation (Stroop test), and emotional stimulation (event recall, patients). Ambulatory blood pressure monitoring and measurement of brachial artery flow–mediated vasodilation were also performed. TC women (tested an average of 37 months after the event) had excessive pressor responses to cognitive stress (Stroop test: p <0.001 vs baseline and p = 0.03 vs controls) and emotional arousal (recall of TC event: p = 0.03 vs baseline). Pressor responses to hemodynamic stimuli were also amplified (Valsalva overshoot: p <0.05) and prolonged (duration: p <0.01) in the TC women compared with controls. Plasma catecholamine levels did not differ between TC women and controls. Indexes of parasympathetic (vagal) modulation of heart rate induced by respiration and cardiovagal baroreflex gain were significantly decreased in the TC women versus controls. In conclusion, even long after the initial episode, women with previous episode of TC have excessive sympathetic responsiveness and reduced parasympathetic modulation of heart rate. Impaired baroreflex control may therefore play a role in TC.
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      Linked Article

      • Autonomic Nervous System Function in Patients With Takotsubo Syndrome
        American Journal of CardiologyVol. 117Issue 7
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          I read the report by Norcliffe-Kaufmann et al1 published in the January 15, 2015, issue of the Journal, about the autonomic nervous system (ANS) evaluation of 10 women with a history of confirmed Takotsubo syndrome (TTS), which they had suffered more than a mean of 3 years previously, with comparisons with 10 normal control subjects. The authors' ANS comprehensive assessment at rest and during physical, emotional, and cognitive stimulation was further amplified with measurements of brachial artery flow-mediated vasodilation, ambulatory blood pressure monitoring, and plasma catecholamine levels.
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      • Brain–Heart Disconnection: A Protective Effect of Diabetes Mellitus in Takotsubo Cardiomyopathy
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          The work by Norcliffe-Kaufmann et al1 published in a recent issue of the American Journal of Cardiology is commendable. The investigators noted excessive pressor responses to cognitive stress, emotional arousal, and hemodynamic stimuli in patients with takotsubo cardiomyopathy (TC), whereas indexes of parasympathetic modulation of heart rate induced by respiration and cardiovagal baroreflex gain were significantly blunted in TC women compared with controls.1
        • Full-Text
        • PDF