Ventricular arrhythmias (VAs) in patients with catecholaminergic polymorphic ventricular
tachycardia type 1 (CPVT1) are triggered at an individual and reproducible heart rate
(HR) during exercise. Long-term effects of exercise on arrhythmia threshold in CPVT1
are not known. To investigate whether exercise training (ET) is feasible in patients
with CPVT1, 13 patients with CPVT1 and confirmed genetic mutations performed bicycle
exercise testing with maximal oxygen uptake (VO2max) measurements at baseline and after 13 weeks. The threshold HR for VA was defined
as the HR when bigeminal ventricular extrasystoles or more severe VAs occurred. Six
patients were enrolled in a 12-week high-intensity ergometer bicycle ET program (ET
patients) with 60 min exercise sessions 3 times per week. The remaining 7 patients
with CPVT1 were included as “sedentary” control (SED) patients complying with current
recommendations to restrain from high-intensity physical activity. ET patients completed
28 ± 3 exercise sessions (78 ± 8% program completion) with 13 ± 3% increase in VO2max versus baseline (20.2 ± 1.6 vs 17.9 ± 1.3 ml/kg/min, p <0.05). No adverse events
occurred. Baseline threshold for VA was 100 ± 6 beats/min in ET patients and 135 ±
4 beats/min in SED patients. After the training period, threshold HR for VA was 111
± 10 beats/min in ET patients and 123 ± 6 beats/min in SED patients. The threshold
for VA increased in ET compared with SED patients (+11 vs −12 beats/min, p <0.05).
In conclusion, patients with CPVT1 benefitted from individualized ET with improved
aerobic capacity and increased threshold HR for VA compared with SED patients.
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Article Info
Publication History
Published online: March 19, 2014
Accepted:
March 5,
2014
Received in revised form:
March 5,
2014
Received:
December 11,
2013
Footnotes
See page 1833 for disclosure information.
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© 2014 Elsevier Inc. Published by Elsevier Inc. All rights reserved.