It is well established that myocardial infarction (MI) associated with coronary artery
bypass grafting (CABG) predicts a poor outcome. Nevertheless, cardioprotective therapies
to limit myocardial injury after CABG are lacking. Previous studies have shown that
curcuminoids decrease proinflammatory cytokines during cardiopulmonary bypass surgery
and decrease the occurrence of cardiomyocytic apoptosis after cardiac ischemia/reperfusion
injury in animal models. We aimed to evaluate whether curcuminoids prevent MI after
CABG compared to placebo. The 121 consecutive patients undergoing CABG were randomly
allocated to receive placebo or curcuminoids 4 g/day beginning 3 days before the scheduled
surgery and continued until 5 days after surgery. The primary end point was incidence
of in-hospital MI. The secondary end point was the effect of curcuminoids on C-reactive
protein, plasma malondialdehyde, and N-terminal pro–B-type natriuretic peptide levels.
Baseline characteristics were comparable between the curcuminoid and placebo groups.
Mean age was 61 ± 9 years. On-pump CABG procedures were performed in 51.2% of patients.
Incidence of in-hospital MI was decreased from 30.0% in the placebo group to 13.1%
in the curcuminoid group (adjusted hazard ratio 0.35, 0.13 to 0.95, p = 0.038). Postoperative
C-reactive protein, malondialdehyde, and N-terminal pro–B-type natriuretic peptide
levels were also lower in the curcuminoid than in the placebo group. In conclusion,
we demonstrated that curcuminoids significantly decreased MI associated with CABG.
The antioxidant and anti-inflammatory effects of curcuminoids may account for their
cardioprotective effects shown in this study.
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Article info
Publication history
Published online: April 05, 2012
Accepted:
February 28,
2012
Received in revised form:
February 28,
2012
Received:
January 3,
2012
Footnotes
This work was supported by Grants MRG 5380258 (Dr. Wongcharoen), MRG 5280169 (Dr. Phrommintikul), and RTA5280006 (Dr. Chattipakorn) from the Thailand Research Fund, Bangkok, Thailand; The Research and Development Institute, the Government Pharmaceutical Organization, Bangkok, Thailand (Dr. Wongcharoen); and the Faculty of Medicine Endowment Fund for Medical Research, Chiang Mai University, Chang Mai, Thailand (Dr. Wongcharoen, Dr. Phrommintikul, and Dr. Chattipakorn).
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Copyright
© 2012 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
