We measured the serum levels of myoglobin, total creatine kinase (CK), and the CK
myocardial (CK-MB), muscle (CK-MM), and brain (CK-BB) isoenzymes in 37 subjects treated
with statins and 43 nonstatin-treated controls running the 2011 Boston Marathon. Venous
blood samples were obtained the day before (PRE) and within 1 hour (FINISH) and 24
hours after (POST) the race. The hematocrit and hemoglobin values were used to adjust
for changes in the plasma volume. The CK distribution was normalized using log transformation
before analysis. The exercise-related increase in CK 24 hours after exercise, adjusted
for changes in plasma volume, was greater in the statin users (PRE to POST 133 ± 15
to 1,104 ± 150 U/L) than in the controls (PRE to POST 125 ± 12 to 813 ± 137 U/L; p
= 0.03 for comparison). The increase in CK-MB 24 hours after exercise was also greater
in the statin users (PRE to POST 1.1 ± 3.9 to 8.9 ± 7.0 U/L) than in the controls
(PRE to POST 0.0 ± 0.0 to 4.2 ± 5.0 U/L; p <0.05 for comparison). However, the increases
in muscle myoglobin did not differ at any point between the 2 groups. Increases in
CK at both FINISH and POST race measurements were directly related to age in the statin
users (r2 = 0.13 and r2 = 0.14, respectively; p <0.05) but not in the controls (r2 = 0.02 and r2 = 0.00, respectively; p >0.42), suggesting that susceptibility to exercise-induced
muscle injury with statins increases with age. In conclusion, our results show that
statins increase exercise-related muscle injury.
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Article Info
Publication History
Published online: October 31, 2011
Accepted:
August 30,
2011
Received in revised form:
August 30,
2011
Received:
July 26,
2011
Footnotes
This study was funded by a research grant from Hartford Hospital (Hartford, Connecticut).
Dr. Thompson is a consultant for AstraZenica International, Wilmington, Delaware, Merck & Co., Inc., Whitehouse Station, New Jersey, the Schering-Plough Corporation, Kenilworth, New Jersey, Takeda Pharmaceutical Company, Limited, Deerfield, Illinois, Roche, Inc., Indianapolis, Indiana, and Genomas, Inc., Hartford, Connecticut and is a member of the speaker's bureau for Merck & Co., Inc., Whitehouse Station, New Jersey, Pfizer, Inc., Groton, Connecticut, Abbott Laboratories, Abbott Park, Illinois, AstraZenica International, Wilmington, Delaware, and the Schering-Plough Corporation, Kenilworth, New Jersey.
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© 2012 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
