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Research Article| Volume 72, ISSUE 12, P944-951, October 15, 1993

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Comparison of morphologic findings in spontaneously occurring hypertrophic cardiomyopathy in humans, cats and dogs

  • Si-Kwang Liu
    Correspondence
    Address for reprints: Si-Kwang Liu, DVM, PhD, Department of Pathology, The Animal Medical Center, 510 East 62nd Street, New York, New York 100021.
    Affiliations
    Department of Pathology, The Animal Medical Center, New York, New York, USA

    Pathology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
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  • William C. Roberts
    Affiliations
    Department of Pathology, The Animal Medical Center, New York, New York, USA

    Pathology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
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  • Barry J. Maron
    Affiliations
    Department of Pathology, The Animal Medical Center, New York, New York, USA

    Pathology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
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DOI:https://doi.org/10.1016/0002-9149(93)91112-U
Comparison of morphologic findings in spontaneously occurring hypertrophic cardiomyopathy in humans, cats and dogs
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      Abstract

      Morphologic features of spontaneously occurring hypertrophic cardiomyopathy (HC) were compared in 38 humans, 51 cats and 10 dogs. Asymmetric hypertrophy of the ventricular septum, marked disorganization of cardiac muscle cells, abnormal intramural coronary arteries and myocardial fibrosis were each present in the ventricular septum of human, feline, and canine forms of HC; these abnormalities were generally more severe and most frequently identified in humans. Asymmetric left ventricular hypertrophy (based on the calculated septal-to-free wall thickness ratio) was most common in humans (31 of 38 [81%]) and dogs (8 of 10 [80%]), as compared with cats (16 of 51 [31%]; p <0.001) with HC; in all 3 species, hypertrophy was often diffuse, involving substantial portions of the anterolateral and posterior free walls, and the ventricular septum. Marked septal disorganization (≥5% of the tissue section) was present in 35 patients (92%), but in only 14 cats (27%) and 2 dogs (20%) (p <0.001). Abnormal intramural coronary arteries occurred with similar frequency in the ventricular septum of patients (n = 25; 66%), cats (n = 38; 74%) and dogs (n = 6; 60%) (p <NS). Moderate-to-severe septal fibrosis was identified more commonly in humans (15 of 38 [39%]) than in animals (13 of 61 [21%]; p s0̌.001). In all 3 species, abnormal intramural coronary arteries were most commonly observed within or at the margins of areas of fibrous tissue. These morphologic findings describe spontaneously occurring models of HC in cats and dogs with substantial structural similarities to the well-recognized disease entity in humans.
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      References

        • Maron B.J.
        • Epstein S.E.
        Hypertrophic cardiomyopathy: a discussion of nomenclature.
        Am J Cardiol. 1979; 43: 1242-1244
        • Teare D.
        Asymmetrical hypertrophy of the heart in young adults.
        Br Heart J. 1958; 20: 1-8
        • Olsen E.G.
        Anatomic and light microscopic characterization of hypertrophic obstructive and nonobstructive cardiomyopathy.
        Eur Heart J. 1983; 4: 1-8
        • Ferrans V.J.
        • Morrow A.G.
        • Roberts W.C.
        Myocardial ultrastructure in idiopathic hypertrophic subaortic stenosis: a study of operatively excised left ventricular outflow tract muscle in 14 patients.
        Circulation. 1972; 45: 769-792
        • Sutton M.S.J.
        • Lie J.T.
        • Anderson K.R.
        • O'Brien P.C.
        • Frye R.L.
        Histopathological specificity of hypertrophic obstructive cardiomyopathy. Myocardial fibre disarray and myocardial fibrosis.
        Br Heart J. 1980; 44: 433-443
        • Maron B.J.
        • Roberts W.C.
        Hypertrophic cardiomyopathy and cardiac muscle cell disorganization revisited- relation between the two and significance.
        Am Heart J. 1981; 102: 95-110
        • Maron B.J.
        • Anan T.J.
        • Roberts W.C.
        Quantitative analysis of the distribution of cardiac muscle cell disorganization in the left ventricular wall of patients with hypertrophic cardiomyopathy.
        Circulation. 1981; 63: 882-894
        • Maron B.J.
        • Sato N.
        • Roberts W.C.
        • Edwards J.E.
        • Chandra R.S.
        Quantitative analysis of cardiac muscle cell disorganization in the ventricular septum: Comparison of fetuses and infants with and without congenital heart disease and patients with hypertrophic cardiomyopathy.
        Circulation. 1979; 60: 685-696
        • Maron B.J.
        • Roberts W.C.
        Quantitative analysis of cardiac muscle cell disorganization in the ventricular septum of patients with hypertrophic cardiomyopathy.
        Circulation. 1979; 59: 689-706
        • Maron B.J.
        • Epstein S.E.
        Hypertrophic cardiomyopathy. Recent observations regarding the specificity of three hallmarks of the disease: asymmetric septal hypertrophy, septal disorganization, and systolic anterior motion of the anterior mitral leaflet.
        Am J Cardiol. 1980; 45: 141-154
        • Isner J.M.
        • Maron B.J.
        • Roberts W.C.
        Comparison of amount of cardiac-musclecell disorganization in operatively-excised septectomy specimens to amount observed at necropsy in 18 patients with hypertrophic cardiomyopathy.
        Am J Cardial. 1980; 46: 42-47
        • Fujiwara H.
        • Kawai C.
        • Hamashima Y.
        Myocardial fascicle and fiber disarray in 25 μ-thick sections.
        Circulation. 1979; 59: 1293-1298
        • Van Noorden S.
        • Olsen E.G.J.
        • Pearse A.G.E.
        Hypertrophic obstructive cardiomyopathy, a histological histochemical, and ultrastructural study of biopsy material.
        Cardiovasc Res. 1971; 5: 118-131
        • Wigle E.D.
        • Sasson Z.
        • Henderson M.A.
        • Ruddy T.D.
        • Fulop J.
        • Rakowski H.
        • Williams W.G.
        Hypertrophic cardiomyopathy. The importance of the site and the extent of hypertrophy. A review.
        Prog Cardiovasc Dis. 1985;; 28: 1-83
        • Maron B.J.
        • Bonow R.O.
        • Cannon R.O.
        • Leon M.B.
        • Epstein S.E.
        Hypertrophic cardiomyopathy: interrelation of clinical manifestations, pathophysiology and therapy.
        N Engl J Med. 1987; 316: 780-789
        • Maron B.J.
        • Bonow R.O.
        • Cannon R.O.
        • Leon M.B.
        • Epstein S.E.
        Hypertrophic cardiomyopathy: interrelation of clinical manifestations, pathophysiology and therapy.
        N Engl J Med. 1987; 316: 844-852
        • McKenna W.J.
        • Camm A.J.
        Sudden death in hypertrophic cardiomyopathy: assessment of patients at high risk.
        Circulation. 1989; 80: 1489-1492
        • Roberts C.S.
        • Roberts W.C.
        Morphologic features.
        in: Progress in Cardiology. 2/2. Lea & Febiger, Philadelphia1989: 3-22
        • Maron B.J.
        • Epstein S.E.
        • Roberts W.C.
        Hypertrophic cardiomyopathy and transmural myocardial infarction without significant atherosclerosis of the extramural coronary arteries.
        Am J Cardiol. 1979; 43: 1086-1102
        • Goodwin J.F.
        Congestive and hypertrophic cardiomyopathies: a decade of study.
        Lancet. 1970; 1: 731-739
        • Spirito P.
        • Maron B.J.
        Relation between extent of left ventricular hypertrophy and diastolic filling abnormalities in hypertrophic cardiomyopathy.
        J Am Coll Cardiol. 1990; 15: 808-813
        • Factor S.M.
        • Butany J.
        • Sole M.J.
        • Wigle E.D.
        • Williams W.C.
        • Rojkind M.
        Pathologic fibrosis and matrix connective tissue in the subaortic myocardium of patients with hyperrophic cardiomyopathy.
        J Am Coll Cardiol. 1991; 17: 1343-1351
        • Tanaka M.
        • Fujiwara H.
        • Onodera T.
        • Wu D.-J.
        • Hamashima Y.
        • Kawai C.
        Quantitative analysis of myocardial fibrosis in normals, hypertensive hearts, and hypertrophic cardiomyopathy.
        Br Heart J. 1986; 55: 575-581
        • Maron B.J.
        • Wolfson J.K.i
        • Epstein S.E.
        • Roberts W.C.
        Intramural (“small vessel”) coronary artery disease in hypernophic cardiomyopathy.
        J Am Coll Cardiol. 1986; 8: 545-557
        • Liu S.K.
        • Maron B.J.
        • Tilley L.P.
        Feline hypertrophic cardiomyopathy: gross anatomic and quantitative histologic features.
        Am J Pathol. 1981; 102: 388-395
        • Tilley L.P.
        • Liu S.K.
        • Gilbertson S.R.
        • Wagner B.M.
        • Lord P.F.
        Primary myocardial disease in the cat.
        Am J Pathol. 1977; 87: 493-522
        • Liu S.K.
        • Maron B.J.
        • Tilley L.P.
        Hypertrophic cardiomyopathy in the dog.
        Am J Pathol. 1979; 94: 497-508
        • Liu S.K.
        • Hsu F.S.
        • Lee R.C.T.
        An Atlas of Cardiovascular Pathology.
        in: Pig Research Institute, Taiwan1989: 198-227
        • Roberts W.C.
        • Ferrans V.J.
        Pathologic anatomy of the cardiomyopathies.
        Hum Pathol. 1975; 6: 287-342
        • Maron B.J.
        • Gottdiener J.S.
        • Epstein S.E.
        Patterns and significance of the distribution of left ventricular hypertrophy in hypertrophic cardiomyopathy: a wide-angle, two-dimensional echocardiographic study of 125 patients.
        Am J Cardiol. 1981; 48: 418-428
        • Maron B.J.
        Asymmetry in hypertrophic cardiomyopathy: the septal to free wall thickness ratio revisited.
        Am J Cardiol. 1985; 55: 835-838

      Article info

      Publication history

      Accepted: June 7, 1993
      Received: February 22, 1993

      Identification

      DOI: https://doi.org/10.1016/0002-9149(93)91112-U

      Copyright

      © 1993 Published by Elsevier Inc.

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