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Abstract
Although the association of serum lipid levels with the risk of atherosclerosis is
well-recognized, the relation between these levels and restenosis after coronary angioplasty
is uncertain. This study examines 186 patients enrolled in a trial of fish oil for
prevention of restenosis. Fasting lipid levels (cholesterol, high density lipoprotein
(HDL) cholesterol and triglycerides) were measured before angioplasty, and in 90 patients
repeated at 6-month follow-up. Fifty-nine patients (32%) developed clinical restenosis
confirmed by angiography. Patients who went on to develop restenosis underwent multivessel
angioplasty (p < 0.05) and were more likely to be on lipid-lowering therapy at baseline
(27 vs 13%; p < 0.05). In addition, they had higher baseline cholesterol/HDL ratios
(6.5 ± 2.2 vs 5.9 ± 2.0; p < 0.05) and triglyceride levels (233 ± 210 vs 183 ± 112
mg/dl; p < 0.05). Multiple logistic regression analysis confirmed cholesterol/HDL
ratios at baseline (p = 0.021) and follow-up (p = 0.0008) to be independent predictors
of risk for restenosis. Using these data, regression lines have been developed that
predict risk of restenosis based on type of procedure and on lipid values. These results
suggest that serum lipid levels may be associated with the risk of clinical restenosis
after coronary angioplasty.
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Article info
Publication history
Accepted:
July 22,
1991
Received:
May 16,
1991
Identification
Copyright
© 1991 Published by Elsevier Inc.
