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Abstract
The relation between velocity of circumferential fiber shortening (VCF) and wall stress
(WS) is being used to estimate contractile state in a variety of disease states and
patient ages more frequently. However, its relation to age has not been established.
To determine reproducibility and age and sex dependence of this relation, 204 normal
children (113 boys, 91 girls) underwent echographic determination of VCF and WS. The
children were enrolled in 3 groups: group 1 < 6 months old (n = 27); group 2 >6 months
and <3 years old (n = 38); and group 3 >3 and <20 years old (n = 139). Twenty-five
children also underwent serial echocardiography (n = 44) to determine reproducibility
of the relation. Only 1 of the 44 repeat data pairs of VCF and WS was outside the
95% confidence limits of that relation. In all 3 groups, VCF was significantly inversely
and linearly related to WS (p < 0.001). The regression equation in the oldest group
was very similar to previous reports (VCF = −0.0031 [WS] + 1.21). The regression lines
in the 2 younger groups were significantly steeper and had a significantly higher
y-intercept (p < 0.01). Group 1 had the steepest slope and highest y-intercept. There
was no difference in the regression lines of different sexes in any of the patient
groups. It is concluded that the relation of VCF to WS is reproducible over time.
It is age-dependent but has no relation to gender. VCF in patients <6 months old is
more highly dependent on WS. Clinician and investigators need to select the appropriate
age-related relation to study contractility in young patients.
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Article Info
Publication History
Accepted:
July 20,
1991
Received in revised form:
July 19,
1991
Received:
June 10,
1991
Footnotes
☆This study was supported in part by a grant from the Ohio Affiliate of the American Heart Association, Cincinnati, Ohio.
Identification
Copyright
© 1991 Published by Elsevier Inc.
