This paper is only available as a PDF. To read, Please Download here.
Abstract
A postmarketing surveillance study on triamterene 75 mg/hydrochlorothiazide 50 mg
was conducted by the Philadelphia Association of Clinical Trials on 70,898 patients.
These patients received either a whole tablet (71% of patients) or half tablet (25.2%
of patients); 61.3% of all patients continued to take the same dose throughout the
4-week study. The most frequent adverse reactions were generally nonspecific and typical
of therapy with a diuretic. The withdrawal rate due to adverse events was significantly
lower (p < 0.005) with the smaller (4.4%) than with the larger (5.6%) dosage. Although
not statistically significant overall, reported adverse reactions also favored a lower
dose.
In general, adverse reactions occurred more frequently in those taking concomitant
medications. No significant difference relating to dose was detected in the percentage
of initially normokalemic patients who became hyper- or hypokalemic by the end of
the study.
Older patients tended to achieve goal blood pressure more frequently than did younger
patients.
These results suggest that the potential for the development of thiazide-induced hypokalemia
and other adverse effects appears to be greatly reduced by the use of a potassium-sparing
agent combined with a thiazide diuretic, without incurring a greatly increased risk
of hyperkalemia and without sacrificing efficacy.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to American Journal of CardiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Post-marketing surveillance.Br Med J. 1980; 280: 1175-1176
- Post-marketing surveillance of adverse reactions to drugs.Br Med J. 1984; 288: 879-880
- Post-marketing follow-up.JAMA. 1979; 242: 2310-2314
- Post-marketing surveillance of adverse drug reactions in general practice: I. Search for new methods.Br Med J. 1981; 282: 1131-1132
- Bioequivalence study of a new tablet formulation of triamterene and hydrochlorothiazide.Am J Med. 1984; 77: 59-61
- A new antihypertensive agent: Maxzide® (75 mg triamterene/50 mg hydrochlorothiazide).Am J Med. 1984; 77: 52-58
- The PACT Study: post-marketing surveillance in 47,465 patients treated with Maxzide® (triamterene/hydrochlorothiazide). An interim report.Am J Med. 1986; 80: 30-36
Hollenberg NK, Mickiewicz C. Hyperkalemia in diabetic mellitus: effect of a triamterene/hydrochlorothiazide combination, Maxzide®. Arch Intern Med; in press.
- Arch Intern Med. 1988; 148: 1023-1038
- Multiple Risk Factor Intervention Trial: risk factor changes and mortality results.JAMA. 1982; 248: 1465-1477
- Immediate and long-term pathophysiologic mechanisms underlying the genesis of sudden cardiac death in patients with congestive heart failure.Am J Med. 1987; 82: 4-10
- Initial serum potassium level in relation to early complications and prognosis in patients with acute myocardial infarction.Acta Med Scand. 1975; 197: 207-210
- Thiazide-induced hypokalemia: association with acute myocardial infarction and ventricular fibrillation.JAMA. 1978; 239: 43-45
- Importance of potassium in patients with acute myocardial infarction.Acta Med Scand. 1981; 647 (suppl): 87-93
- Hypokalemia and ventricular fibrillation in acute myocardial infarction.Br Heart J. 1983; 50: 525-529
- Malignant arrhythmias in acute myocardial infarction.Drugs. 1984; 28 (suppl): 11-85
- Cardiac dysrhythmias in patients with acute myocardial infarction.Acta Med Scand. 1984; 216: 127-132
- Diuretic-induced hypokalemia.Am J Med. 1984; 77: 18-27
- Blood pressure reduction in mildly hypertensive elderly patients does not impair cognitive or behavioral function.Int Soc Hypertens. 1988; 12 (abstr 346)
- Drug-induced hyperkalemia.Medicine. 1985; 64: 357-370
- Post-marketing studies of drug efficacy: when must they be randomized?.Clin Pharmacol Ther. 1983; 34: 1-7
- Post-marketing studies of drug efficacy.Arch Intern Med. 1985; 145: 1791-1794
Article Info
Identification
Copyright
© 1989 Published by Elsevier Inc.