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Correlation of right ventricular volume using axial angulated ventriculography to known right ventricular cast volumes in infants and children with congenital heart disease

  • Toshihiro Ino
    Footnotes
    Affiliations
    From the Department of Pediatrics, Division of Cardiology, The Variety Club Cardiac Catheterization Laboratories, The Hospital for Sick Children, Toronto, Ontario, Canada
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  • Lee N. Benson
    Correspondence
    Address for reprints: Lee N. Benson, MD, The Hospital for Sick Children, Room 4515, 555 University Avenue, Toronto, Ontario, Canada, M5G 1X8.
    Affiliations
    From the Department of Pediatrics, Division of Cardiology, The Variety Club Cardiac Catheterization Laboratories, The Hospital for Sick Children, Toronto, Ontario, Canada
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  • Haverj Mikailian
    Affiliations
    From the Department of Pediatrics, Division of Cardiology, The Variety Club Cardiac Catheterization Laboratories, The Hospital for Sick Children, Toronto, Ontario, Canada
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  • Robert M. Freedom
    Affiliations
    From the Department of Pediatrics, Division of Cardiology, The Variety Club Cardiac Catheterization Laboratories, The Hospital for Sick Children, Toronto, Ontario, Canada
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  • Richard D. Rowe
    Affiliations
    From the Department of Pediatrics, Division of Cardiology, The Variety Club Cardiac Catheterization Laboratories, The Hospital for Sick Children, Toronto, Ontario, Canada
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  • Author Footnotes
    1 Dr. Ino's work was supported in part by a grant from The Research Institute, The Hospital for Sick Children, Toronto.
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      Abstract

      To calculate right ventricular (RV) volumes from biplane cineangiography obtained in nonstandard views, regression equations were developed from RV casts of known volume. Volumes were calculated using Simpson's rule from casts ranging from 2 to 42 ml from 25 postmortem specimens with various congenital heart diseases. The casts were divided into 2 groups: group 1 (n = 15) with abnormal or group 2 (n = 10) with normal RV hemodynamic measurements. Biplane cinegrams were taken in the anterolateral, anterior and long axis oblique, hepatoclavicular and sitting up projections. The true volume of each cast was determined from its weight and specific gravity. Excellent correlations were obtained between measured and true volumes (r = 0.92 to 0.96) in all projections, although each projection overestimated the true volume (slope value <1). The regression equations obtained from group 1 were not statistically different from those in group 2 in any view. Although the application of different regression equations is required in measuring RV volumes by multiple angulated angiography, these regression equations appear not to be affected by the hemodynamic state of the ventricle. These results are important in assessing RV volume in pediatric patients with congenital heart disease using axial angulated ventriculography.
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