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Abstract
One hundred patients with inducible ventricular tachycardia (VT) on electrophysiologic
studies underwent serial drug testing with procainamide, lidocaine and lorcainide
to determine comparative efficacy. Acute intravenous administration was followed by
repeat programmed electrical stimulation (PES) studies on separate days for each antiarrhythmic
agent. Lorcainide prevented VT induction in 69% of the 100 patients studied, procainamide
in 50% of the 75 patients studied and lidocaine in 30% of 53 patients. After PES and
serial drug testing, 46 patients were started on lorcainide, 9 on procainamide and
45 on other antiarrhythmic drug regimens. Eighty percent of the patients have remained
on lorcainide therapy, whereas 47% have continued on other drug therapies started
over 17.5-month mean follow-up period. Despite sleepwake disturbances and a need for
sedation at night, lorcainide therapy was well tolerated in this population and remained
an effective antiarrhythmic agent with prolonged administration.
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Article info
Footnotes
☆This study was supported in part by Janssen Pharmaceutica, Inc. Dr. Somberg is an Established Investigator of the American Heart Association.
Identification
Copyright
© 1984 Published by Elsevier Inc.
