This paper is only available as a PDF. To read, Please Download here.
Abstract
Lorcainide, 100 mg twice daily was compared with placebo in 39 patients with frequent
ventricular arrhythmias in a randomized double-blind crossover trial. A mean frequency
of ventricular premature beats (VPBs) of at least 30 VPBs/hour was required during
a drug-free period of 48 hours. Holter monitoring and a maximal symptom-limited exercise
test were performed at the end of each of the 2-week double-blind treatment phase.
The group averaged 350 ± 361 (standard deviation) VPBs/hour. Lorcainide decreased
the mean VPB frequency of the group by 46% (p <0.01), with VPB reduction beyond the
expected variation in 22 of 39 patients. In 13 patients VPBs were unchanged and in
4 they increased. Eight additional patients responded during drug titration, for an
overall response rate of 77% (30 of 39). Lorcainide did not significantly reduce the
exercise-related VPB frequency. At 6 months 61% of patients had significant VPB suppression.
Thus, lorcainide was effective in reducing the frequency and grade of spontaneous
ventricular arrhythmias during short- and long-term evaluation.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to American Journal of CardiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Factors influencing long-term prognosis after recovery from myocardial infarction: 3-year findings of the coronary drug project.J Chronic Dis. 1974; 27: 267-285
- Ventricular premature beats and mortality after myocardial infarction.N Engl J Med. 1977; 297: 750-757
- Nonsustained ventricular tachycardia in ambulatory patients: characteristics in association with sudden death.Ann intern Med. 1980; 92: 741-747
- Long-term survival of patients with malignant ventricular arrhythmia treated with antiarrhythmic drugs.Am J Cardiol. 1982; 50: 437-443
- Suppression of the repetitive ventricular response: an index of long-term antiarrhythmic effectiveness of aprindine for ventricular tachycardia in man.Am J Cardiol. 1978; 42: 1007-1012
- Antiarrhythmic drug therapy in survivors of prehospital cardiac arrest: comparison of effects on chronic ventricular arrhythmias and recurrent cardiac arrest.Circulation. 1979; 59: 855-863
- Lorcainide (REMIVOX; R 15, 889): an oral and intravenous antiarrhythmic with long duration of action.in: Investigators Brochure B-2340. 2nd Ed. Breese, Belgium1981
- Antiarrhythmic etectrophysiological and hemodynamic effects of lorcainide.Arch int Pharmacodyn Ther. 1977; 231: 104-130
- Comparative effects of lignocaine and lorcainide on conduction in the Langendorff-perfused guinea pig heart.Cardiovasc Res. 1979; 13: 439-449
- Intracardiac electrophysiological effects of lorcainide in man.Eur J Clin Pharmacol. 1979; 15: 241-247
- Electrophysiological actions of lorcainide in patients with cardiac disease.J Cardiovasc Pharmacol. 1979; 1: 343-352
- Clinical experience with lorcainide (R 15889) a new antiarrhythmic drug.Arch int Pharmacodyn Ther. 1977; 230: 225-234
- Initial clinical experience with lorcainide (Ro 131042/100), a new antiarrhythmic agent.Eur J Clin Pharmacol. 1978; 14: 105-109
- Lorcainide infusion in treatment of ventricular premature beats.Eur J Clin Pharmacol. 1979; 16: 1-6
- Trial of lorcainide for suppression of ventricular arrhythmias, (abstr).Clin Pharmacol Ther. 1981; 29: 257
- Pharmacokinetics of lorcainide, a new antiarrhythmic drug in patients with cardiac rhythm disorders.Am J Cardiol. 1981; 48: 156-162
- A validation technique for computerized Holter tape processing systems used in drug efficacy testing.in: Ostrow H.G. Ripley K.L. Computers in Cardiology. IEEE Computer Society, Long Beach, California1977: 199-209
- Approaches to sudden death from coronary heart disease.Circulation. 1971; 44: 130-142
- The “R or T” phenomenon.Ann Intern Med. 1978; 88: 221-225
- Comparison of acebutolol and propranolol for treatment of chronic ventricular arrhythmia: a placebo-controlled, double-blind, randomized crossover study.Circulation. 1982; 65: 1356-1364
- Propranolol for patients with mitral valve prolapse.Am Heart J. 1977; 93: 422-427
- Limitations of routine long-term electrocardiographic recording to assess ventricular ectopic frequency.Circulation. 1978; 58: 408-414
- Spontaneous variability of complex ventricular arrhythmias detected by long-term electrocardiographic recordings.Circulation. 1980; 61: 690-695
- Antiarrhythmic drug effect mimicked by spontaneous variability of ventricular ectopy.Circulation. 1978; 57: 1116-1121
- A new method of evaluating antiarrhythmic drug efficacy.Circulation. 1980; 62: 1172-1179
- Aggravation of ventricular arrhythmia by antiarrhythmic drugs (abstr).Am J Cardiol. 1979; 43: 359
Article info
Publication history
with the statistical assistance of James L. Cockrell, BS
Footnotes
☆This study was supported in part by the Veterans Administration, Washington, D.C.
Identification
Copyright
© 1984 Published by Elsevier Inc.
