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Abstract
A family affected with hyperbetalipoproteinemia was studied. Two siblings, a boy 11
and a girl 9 years of age, with characteristic findings of homozygous type II hyperlipoproteinemia
are described. The highly atherogenetic nature of this disorder is illustrated by
the occurrence of progressive coronary atheromatosis in the boy, in whom two coronary
arteriographic studies documented the development of progressive obstruction of two
coronary arteries in the course of 2 years. During this interval angina pectoris developed
followed by myocardial infarction, cardiomegaly and congestive heart failure. The
sister has remained asymptomatic, with apparently normal coronary arteries at age
9 years. Phonocardiograms were suggestive of aortic valve involvement although no
aortic valve gradient was demonstrated by cardiac catheterization.
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Article info
Publication history
Accepted:
July 2,
1974
Identification
Copyright
© 1975 Published by Elsevier Inc.
