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Abstract
Left ventricular performance was studied in three patients with heart failure due
to amyloid deposits. The diagnosis of amyloidosis was proved by cardiac biopsy in
two patients and by rectal biopsy in the third. One patient had myelomatosis, but
the other two had no other identifiable disease. The investigative technique allowed
simultaneous measurements of pressure and volume in the left ventricle. The functional
defect with slow cardiac filling at high pressure and greatly reduced left ventricular
contraction differed from that of constrictive pericarditis and other heart muscle
disease. These features of a “stiff heart” are probably unique to amyloidosis and
should make possible positive recognition of the condition on the basis of echocardiographic,
angiographic and hemodynamic findings.
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Article info
Publication history
Accepted:
January 29,
1975
Identification
Copyright
© 1975 Published by Elsevier Inc.
