This paper is only available as a PDF. To read, Please Download here.
An experimental model of a prolapsing left atrial tumor mass has been utilized In dogs to study the hemodynamic events of the cardiac cycle and the cineangiographic and echocardiographic manifestations of this condition. The characteristic ventricular notch has been correlated with the timing of the expulsion of the simulated tumor mass from the left ventricle to the left atrium. The early notch seen with small simulated tumors delays aortic ejection by 0.02 to 0.03 second and results in abbreviated aortic ejection time and minimal distortion of the E-F slope of anterior mitral leaflet motion in the echocardiogram. Larger masses lead to late ventricular notching, transiently interrupt aortic flow and may displace the anterior mitral leaflet until It impinges on the interventricular septum in mid-diastole and at the onset of systole. A transient systolic Increment of coronary flow is observed after expulsion of the tumor from the left ventricle into the left atrium. There is an echo-free interval immediately after opening of the mitral valve, indicating that tumor motion lags perceptibly behind the initial blood flow through the mitral orifice. The sudden expulsion of the mass from the ventricle to the atrium early in systole represents an in vivo example of the quick release phenomenon.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to American Journal of Cardiology
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Diagnosis of left atrial myxoma.Lancet. 1963; 1: 464-468
- Calcified left atrial myxoma simulating mitral insufficiency. Hemodynamic and phonocardiographic effects of tumor movement.Circulation. 1967; 36: 417-421
- Myxoma of the left atrium. Hemodynamic and phonocardiographic consequences of sudden tumor movement.Circulation. 1967; 36: 408-416
- Left atrial myxoma. Phonocardiographic clues to diagnosis.Am J Cardiol. 1969; 23: 588-591
- Unusual hemodynamic findings of diagnostic value in a case of left atrial myxoma.Am J Cardiol. 1969; 23: 592-596
- Atrial myxoma. II. Phonocardiographic, echocardiographic, hemodynamic, and angiographic features in nine cases.Am Heart J. 1972; 83: 810-824
- Protean clinical manifestations of primary tumors of the heart.Am J Med. 1972; 52: 9-18
- Left atrial myxoma. Hemodynamic and phonocardiographic features.Am J Med. 1972; 52: 525-532
- Left atrial myxoma with bacteremia. Report of a case with a bifid systolic apical impulse.Am J Cardiol. 1970; 25: 353-358
- Left atrial myxoma: evidence of tumor movement by apexcardiogram.Chest. 1971; 60: 280-282
- Left atrial myxoma. Diagnosis with the help of the phonocardiogram and apexcardiogram.Arch Intern Med. 1972; 129: 470-474
- An opening snap recorded in a case of tumor of the left atrium.N Engl J Med. 1957; 257: 178-180
- Clinicopathologic conference. second ed. N Engl J Med. 287. 1972: 555-561
- Echocardiographic diagnosis of left atrial myxoma.in: second ed. Mayo Clin Proc. 61. 1968: 620-627
- Diagnosis of atrial tumors by ultrasound.Circulation. 1969; 39: 615-622
- Echocardiographic diagnosis of left atrial myxoma.Chest. 1970; 58: 550-552
- Pressure transients occurring in diastole in the central aorta.Circ Res. 1963; 13: 585-594
- Profile of atrial myxoma.Am J Cardiol. 1968; 21: 367-375
- N Engl J Med. 281. 1969: 425-433 Seminars in medicine of the Beth Israel Hospital, Boston: mitral regurgitation. second ed.
- Echocardiographic diagnosis of right atrial myxoma.in: second ed. Mayo Clin Proc. 48. 1973: 284-286
- Fluid mechanics of a model mitral valve.J Physiol. 1970; 207: 72-73
- Newer aspects of echocardiography.Circulation. 1973; 37: 833-842
- The posterior mitral valve echo and the electrocardiographic diagnosis of mitral stenosis.Am J Cardiol. 1972; 29: 628-632
- Time course of the active state in relation to muscle length and movement: a comparative study on skeletal muscle and myocardium.Cardiovasc Res. 1971; 1: 3-10
Accepted: January 3, 1974
© 1974 Published by Elsevier Inc.