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Experimental study| Volume 34, ISSUE 1, P63-71, July 1974

Simulated left atrial tumor

A hemodynamic, echocardiographic and cineangiographic study
  • Howard L. Moscovitz
    Correspondence
    Address for reprints: Howard L. Moscovitz, MD, the Mount Sinai School of Medicine of the City University of New York, Fifth Ave. and 100th St., New York, New York 10029.
    Affiliations
    From the Division of Cardiology, Department of Medicine, the Mount Sinai Hospital and Mount Sinai School of Medicine of the City University of New York, New York, N. Y., USA
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  • John Pantazopoulos
    Affiliations
    From the Division of Cardiology, Department of Medicine, the Mount Sinai Hospital and Mount Sinai School of Medicine of the City University of New York, New York, N. Y., USA
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  • Monty Bodenheimer
    Affiliations
    From the Division of Cardiology, Department of Medicine, the Mount Sinai Hospital and Mount Sinai School of Medicine of the City University of New York, New York, N. Y., USA
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  • Moshe Steier
    Affiliations
    From the Division of Cardiology, Department of Medicine, the Mount Sinai Hospital and Mount Sinai School of Medicine of the City University of New York, New York, N. Y., USA
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  • Ira J. Gelb
    Affiliations
    From the Division of Cardiology, Department of Medicine, the Mount Sinai Hospital and Mount Sinai School of Medicine of the City University of New York, New York, N. Y., USA
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DOI:https://doi.org/10.1016/0002-9149(74)90094-0
Simulated left atrial tumor
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      Abstract

      An experimental model of a prolapsing left atrial tumor mass has been utilized In dogs to study the hemodynamic events of the cardiac cycle and the cineangiographic and echocardiographic manifestations of this condition. The characteristic ventricular notch has been correlated with the timing of the expulsion of the simulated tumor mass from the left ventricle to the left atrium. The early notch seen with small simulated tumors delays aortic ejection by 0.02 to 0.03 second and results in abbreviated aortic ejection time and minimal distortion of the E-F slope of anterior mitral leaflet motion in the echocardiogram. Larger masses lead to late ventricular notching, transiently interrupt aortic flow and may displace the anterior mitral leaflet until It impinges on the interventricular septum in mid-diastole and at the onset of systole. A transient systolic Increment of coronary flow is observed after expulsion of the tumor from the left ventricle into the left atrium. There is an echo-free interval immediately after opening of the mitral valve, indicating that tumor motion lags perceptibly behind the initial blood flow through the mitral orifice. The sudden expulsion of the mass from the ventricle to the atrium early in systole represents an in vivo example of the quick release phenomenon.
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      Article info

      Publication history

      Accepted: January 3, 1974

      Identification

      DOI: https://doi.org/10.1016/0002-9149(74)90094-0

      Copyright

      © 1974 Published by Elsevier Inc.

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