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Abstract
The relation between changes in left ventricular wall systolic thickening and other
measures of left ventricular function were studied during regional ischemia in 14
open chest pigs. A fixed decrease in coronary peak blood flow from 46 ± 5 (standard
error) to 13 ± 2 ml/min was produced using a screw clamp and flow probe placed around
the left anterior descending coronary artery. Myocardial wall thickness was measured
with a calibrated harpoon mercury strain gauge placed through the apical portion of
the left ventricle and recorded continuously with left ventricular systolic pressure,
the first derivative of left ventricular pressure rise (![Math Eq]()
) and pressure-derived peak velocity of contraction. During systole, the left ventricle
thickened by 10.7 ± 2.1 percent of its total average thickness of 12.7 ± 0.7 mm. Within
6 seconds of the onset of ischemia total myocardial wall thickness decreased from
1.356 ± 0.135 to 0.592 ± 0.081 mm (P < 0.001) or to 45.2 ± 5.1 percent of the control value. During ischemia, changes
were noted in both the isovolumic and the ejection phases of systole in addition to
left ventricular wall thinning of 0.282 ± 0.02 mm at enddiastole. There was no significant
change in left ventricular pressure or its derived values. In two experiments isolated
wall thickness alternans was observed. These studies indicate that myocardial wall
thickness is more sensitive than ventricular pressure as a measure of local changes
in myocardial function during regional myocardial ischemia.
) and pressure-derived peak velocity of contraction. During systole, the left ventricle
thickened by 10.7 ± 2.1 percent of its total average thickness of 12.7 ± 0.7 mm. Within
6 seconds of the onset of ischemia total myocardial wall thickness decreased from
1.356 ± 0.135 to 0.592 ± 0.081 mm (P < 0.001) or to 45.2 ± 5.1 percent of the control value. During ischemia, changes
were noted in both the isovolumic and the ejection phases of systole in addition to
left ventricular wall thinning of 0.282 ± 0.02 mm at enddiastole. There was no significant
change in left ventricular pressure or its derived values. In two experiments isolated
wall thickness alternans was observed. These studies indicate that myocardial wall
thickness is more sensitive than ventricular pressure as a measure of local changes
in myocardial function during regional myocardial ischemia.To read this article in full you will need to make a payment
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![Math Eq]()
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(abstr).Article info
Publication history
Accepted:
December 5,
1973
Footnotes
☆This study was carried out during Dr. Goldstein's tenure as Visiting Professor at the Thoraxcenter, Medical Faculty, Erasmus University Rotterdam, Rotterdam, The Netherlands.
Identification
Copyright
© 1974 Published by Elsevier Inc.
