Experimental study| Volume 34, ISSUE 1, P56-62, July 1974

Changes in left ventricular wall dimensions during regional myocardial ischemia

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      The relation between changes in left ventricular wall systolic thickening and other measures of left ventricular function were studied during regional ischemia in 14 open chest pigs. A fixed decrease in coronary peak blood flow from 46 ± 5 (standard error) to 13 ± 2 ml/min was produced using a screw clamp and flow probe placed around the left anterior descending coronary artery. Myocardial wall thickness was measured with a calibrated harpoon mercury strain gauge placed through the apical portion of the left ventricle and recorded continuously with left ventricular systolic pressure, the first derivative of left ventricular pressure rise (Math Eq) and pressure-derived peak velocity of contraction. During systole, the left ventricle thickened by 10.7 ± 2.1 percent of its total average thickness of 12.7 ± 0.7 mm. Within 6 seconds of the onset of ischemia total myocardial wall thickness decreased from 1.356 ± 0.135 to 0.592 ± 0.081 mm (P < 0.001) or to 45.2 ± 5.1 percent of the control value. During ischemia, changes were noted in both the isovolumic and the ejection phases of systole in addition to left ventricular wall thinning of 0.282 ± 0.02 mm at enddiastole. There was no significant change in left ventricular pressure or its derived values. In two experiments isolated wall thickness alternans was observed. These studies indicate that myocardial wall thickness is more sensitive than ventricular pressure as a measure of local changes in myocardial function during regional myocardial ischemia.
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        • Tennant R
        • Wiggers CJ
        The effect of coronary occlusion on myocardial contraction.
        Am J Physiol. 1935; 112: 351-361
        • Herman MV
        • Heinle RA
        • Klein MD
        • et al.
        Localized disorders in myocardial contraction.
        N Engl J Med. 1967; 277: 222-232
        • Hood Jr, WB
        • McCarthy B
        • Lown B
        Myocardial infarction following coronary ligation in dogs.
        Circ Res. 1967; 21: 191-199
        • Hood Jr, WB
        • Covelli JH
        • Abelmann WH
        • et al.
        Persistence of contractile behaviour in acutely ischaemic myocardium.
        Cardiovasc Res. 1969; 3: 249-260
        • Newman WH
        • Walton RP
        Strain-gauge arch recordings from acutely ischemic area of the left ventricle.
        J Appl Physiol. 1967; 23: 398-400
        • Sonnenblick EH
        • Kirk ES
        Effects of hypoxia and ischemia on myocardial contraction.
        Cardiology. 1971/1972; 56: 302-313
        • Brower RW
        • Roelandt JR
        • Meester GT
        Analog calculation of Math Eq (abstr).
        Circulation. 1971; 44: II-53
        • Van der Meer JJ
        • Jageneau AHM
        • Elzinga G
        • et al.
        Changes in myocardial wall thickness (MWT) in open chest dogs.
        Pfluegers Arch. 1973; 340: 35-50
        • Heikkilä J
        • Tabakin BS
        • Hugenholtz PG
        Quantification of function in normal and infarcted regions of the left ventricle.
        Cardiovasc Res. 1972; 6: 516-531
        • Bove AA
        • Lynch PR
        Measurement of canine left ventricular performance by cineradiography of the heart.
        J Appl Physiol. 1970; 29: 877-883
        • Bove AA
        Radiographic evaluation of dynamic geometry of the left ventricle.
        J Appl Physiol. 1971; 31: 227-234
        • Eber LM
        • Greenberg HM
        • Cooke JM
        • et al.
        Dynamic changes in left ventricular free wall thickness in the human heart.
        Circulation. 1969; 39: 455-464
        • Hugenholtz PG
        • Kaplan E
        • Hull E
        Determination of left ventricular wall thickness by angiocardiography.
        Am Heart J. 1969; 78: 513-522
        • Mitchell JH
        • Wildenthal K
        • Mullins CB
        Geometrical studies of the left ventricle utilizing biplane cinefluorography.
        in: second ed. Fed Proc. 28. 1969: 1334-1343
        • Feigl EO
        • Fry DL
        Myocardial mural thickness during the cardiac cycle.
        Circ Res. 1964; 19: 541-545
        • Cothran LN
        • Bowle WC
        • Hinds JE
        • et al.
        Left ventricular wall thickness changes in unanesthetized horses.
        in: Tanz RD Kavaler F Roberts G Factors Influencing Myocardial Contractility. Academic Press, New York1967: 163-177
        • Guntheroth WG
        Systolic changes in ventricular thickness in intact dogs (abstr).
        Circulation. 1971; 44: II-173
        • Leshin SJ
        • Mullins CB
        • Templeton GH
        • et al.
        Dimensional analysis of ventricular function: effects of anesthetics and thoracotomy.
        Am J Physiol. 1972; 222: 540-545
        • Guntheroth WG
        • Morgan BC
        • McGough GA
        • et al.
        Alternate deletion and potentiation as the cause of pulsus alternans.
        Am Heart J. 1969; 78: 669-681
        • Noble RJ
        • Nutter DO
        The demonstration of alternating contractile state in pulsus alternans.
        J Clin Invest. 1970; 49: 1166-1177
        • Case RB
        • Nasser MG
        • Crampton RS
        Biochemical aspects of early myocardial ischemia.
        Am J Cardiol. 1969; 24: 766-775
        • Schelbert HR
        • Covell JW
        • Burns JW
        • et al.
        Observations on factors affecting local forces in the left ventricular wall during acute myocardial ischemia.
        Circ Res. 1971; 29: 306-316
        • Owen P
        • Thomas M
        • Young V
        • et al.
        Comparison between metabolic changes in local venous and coronary sinus blood after acute experimental coronary arterial occlusion.
        Am J Cardiol. 1970; 25: 562-570
      1. De Jong JW, Goldstein S: Changes in coronary venous inosine concentration and myocardial wall thickening during regional ischemia in the pig. Circ Res, in press