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Abstract
Although lidocaine is an effective antiarrhythmic agent, it must be administered parenterally
and its duration of activity is short. Astra W36095 has a basic chemical structure
similar to that of lidocaine but has a plasma half-life of 8 to 12 hours after administration
to conscious dogs. Ventricular arrhythmias were produced in unanesthetized dogs, using
ameroid constrictors on the proximal left anterior descending and circumflex coronary
arteries. Stable ectopic beats were completely suppressed with plasma levels of 15
to 30 μg/ml of W36095. The duration of effect was 0.25 to 5 hours. In anesthetized
dogs, an effective antiarrhythmic concentration of W36095 produced some depression
of cardiac function. Thus, W36095 appears to be a long-acting, orally absorbed antiarrhythmic
agent requiring clinical trials and metabolic studies. In addition, the arrhythmia
model provides a sensitive method for studying new antiarrhythmic drugs.
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Article info
Publication history
Accepted:
December 5,
1973
Footnotes
☆This work was supported in part by Grants HL-5709 and HL-5966 from the National Institutes of Health, Bethesda, Md.
Identification
Copyright
© 1974 Published by Elsevier Inc.
