Experimental Study| Volume 34, ISSUE 1, P35-41, July 1974

Antiarrhythmic and circulatory effects of astra W36095

A new lidocaine-like agent
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      Although lidocaine is an effective antiarrhythmic agent, it must be administered parenterally and its duration of activity is short. Astra W36095 has a basic chemical structure similar to that of lidocaine but has a plasma half-life of 8 to 12 hours after administration to conscious dogs. Ventricular arrhythmias were produced in unanesthetized dogs, using ameroid constrictors on the proximal left anterior descending and circumflex coronary arteries. Stable ectopic beats were completely suppressed with plasma levels of 15 to 30 μg/ml of W36095. The duration of effect was 0.25 to 5 hours. In anesthetized dogs, an effective antiarrhythmic concentration of W36095 produced some depression of cardiac function. Thus, W36095 appears to be a long-acting, orally absorbed antiarrhythmic agent requiring clinical trials and metabolic studies. In addition, the arrhythmia model provides a sensitive method for studying new antiarrhythmic drugs.
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