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Symposium on myocardial metabolism| Volume 22, ISSUE 3, P328-336, September 01, 1968

Oxygen consumption of the heart

Newer concepts of its multifactoral determination
DOI:https://doi.org/10.1016/0002-9149(68)90117-3
Oxygen consumption of the heart
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      Abstract

      The development of tension and the contractile state of the myocardium are the primary determinants of myocardial oxygen consumption. Recognition of these two factors and their interrelation has served to explain a number of apparent discrepancies in the literature. Other factors, including basal myocardial oxygen consumption, activation energy and external work, also contribute to the myocardial oxygen consumption, but to a relatively minor extent. An understanding of these general principles should permit a more rational consideration of the determinants of myocardial oxygen consumption and the implications of these factors in disease states.
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      Article Info

      Footnotes

      ☆From the Cardiovascular Unit, Peter Bent Brigham Hospital, and Harvard Medical School, Boston, Mass.; From the Cardiovascular Unit, Peter Bent Brigham Hospital, and Harvard Medical School, Boston, Mass. This work was supported in part by U. S. Public Health Service Grant No. 9373-2 and in part by American Heart Association Grant No. 9171-2.

      Identification

      DOI: https://doi.org/10.1016/0002-9149(68)90117-3

      Copyright

      © 1968 Published by Elsevier Inc.

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