Reduction of serum triglycerides and cholesterol by ethyl p-chlorophenoxyisobutyrate (CPIB)

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      Ethyl p-chlorophenoxyisobutyrate (CPIB) was administered alone and in combination with androsterone to 10 patients with elevations of serum cholesterol and/or triglycerides. Serum lipid levels during the two four-month treatment periods were compared to those during a period of placebo administration of similar duration, the order of the periods being randomized.
      As compared to the placebo period, a mean reduction in serum triglycerides and, to a lesser extent, cholesterol occurred during the administration of both CPIB alone and CPIB with androsterone. The addition of androsterone to the CPIB did not significantly enhance the hypolipemic activity of CPIB. No adverse effect or toxicity was encountered.
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        • Oliver M.F.
        Reduction of serum-lipid and uric-acid levels by an orally active androsterone.
        Lancet. 1962; 1: 1321
        • Hellman L.
        • Bradlow H.L.
        • Zumoff B.
        • Fukushima D.K.
        • Gallagher T.F.
        Thyroid-androgen interrelations and the hypocholesteremic effect of androsterone.
        J. Clin. Endocrinol. 1959; 19: 936
        • Berkowitz D.
        Selective blood lipid reductions by newer pharmacologic agents.
        Am. J. Cardiol. 1963; 12: 834
        • Best M.M.
        • Duncan C.H.
        Effects of cholesterol-lowering drugs on serum triglycerides.
        J.A.M.A. 1964; 187: 37
        • Hellman L.
        • et al.
        Reduction of cholesterol and lipids in man by ethyl p-chlorophenoxyisobutyrate.
        Ann. Int. Med. 1963; 59: 477
        • Oliver M.F.
        Further observations on the effects of Atromid and of ethyl chlorophenoxyisobutyrate on serum lipid levels.
        J. Atheroscler. Res. 1963; 3: 427
        • Howard R.P.
        • Alaupovic P.
        • Brusco O.J.
        • Furman R.H.
        Effects of ethyl chlorophenoxyisobutyrate alone or with androsterone (Atromid) on serum lipids, lipoproteins and related metabolic parameters in normal and hyperlipemic subjects.
        J. Atheroscler. Res. 1963; 3: 482
        • Abell L.L.
        • Levy B.B.
        • Brodie B.B.
        • Kendall F.E.
        A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity.
        J. Biol. Chem. 1952; 195: 357
        • Van Handel E.
        • Zilversmit D.B.
        Micromethod for the direct determination of serum triglycerides.
        J. Lab. Clin. Med. 1957; 50: 152
        • Trout D.L.
        • Estes Jr., E.H.
        • Friedberg S.J.
        Titration of free fatty acids of plasma: A study of current methods and a new modification.
        J. Lipid Res. 1960; 1: 199
        • Strisower E.H.
        • Strisower B.
        The separate hypolipoproteinemic effects of dextrothyroxine and ethyl chlorophenoxyisobutyrate.
        J. Clin. Endocrinol. 1964; 24: 139
        • Azarnoff D.L.
        • Tucker D.R.
        Studies on mechanism of action of clofibrate.
        in: Fed. Proc.23. 1964: 552
        • Best M.M.
        • Duncan C.H.
        Hypoglyceridemic effect of ethyl-a-p-chlorophenoxyisobutyrate with and without androsterone.
        Circulation. 1963; 28: 690
        • Oliver M.F.
        • et al.
        Effect of Atromid and ethyl chlorophenoxyisobutyrate on anticoagulant requirements.
        Lancet. 1963; 1: 143
        • Green K.G.
        • Inman W.H.W.
        • Thorp J.M.
        Multicentre trial in the United Kingdom and Ireland of a mixture of ethyl chlorophenoxyisobutyrate and androsterone (Atromid).
        J. Atheroscler. Res. 1963; 3: 593