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Reduction of serum triglycerides and cholesterol by ethyl p-chlorophenoxyisobutyrate (CPIB)

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      Abstract

      Ethyl p-chlorophenoxyisobutyrate (CPIB) was administered alone and in combination with androsterone to 10 patients with elevations of serum cholesterol and/or triglycerides. Serum lipid levels during the two four-month treatment periods were compared to those during a period of placebo administration of similar duration, the order of the periods being randomized.
      As compared to the placebo period, a mean reduction in serum triglycerides and, to a lesser extent, cholesterol occurred during the administration of both CPIB alone and CPIB with androsterone. The addition of androsterone to the CPIB did not significantly enhance the hypolipemic activity of CPIB. No adverse effect or toxicity was encountered.
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