Tolerance of reserpinized dogs to digitalis

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      Reserpinized dogs showed a consistent increase in the lethal dose of digoxin ranging from 45 to 57 per cent above the average value obtained in the normal dog. This increase is probably due to the depletion of catecholamine stores that occurs with administration of reserpine. This result would appear to have implications in the use of the combination of these drugs in the human subject.
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