Studies following intramuscular tritiated digoxin in human subjects

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      Ten patients were digitalized by the intramuscular route with tritium-labeled digoxin. Radioactivity levels of the serum, urine and stools were studied for seven days.
      Serum digoxin radioactivity is present in 5 minutes, rises slowly to a peak at about 2Math Eq hours and then declines slowly to a plateau at 12 hours.
      Two exponential curves may be constructed from the serum turnover curve: (1) An early phase of tissue distribution and binding with a half-time of 100 minutes and (2) a late dominant curve of metabolism and excretion with a halftime of 38 hours.
      The dominant turnover time is similar to that observed with intravenous and intramuscular studies, but differences are noted in the early phase. The serum concentration was lower than that found after the intravenous route and greater than after the oral route.
      After seven days, 50 per cent of the administered dose appeared in the urine and 10 per cent in the stool.
      Minor local reaction at the injection sites was noted in each patient studied.
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