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Abstract
Ten patients were digitalized by the intramuscular route with tritium-labeled digoxin.
Radioactivity levels of the serum, urine and stools were studied for seven days.
Serum digoxin radioactivity is present in 5 minutes, rises slowly to a peak at about
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hours and then declines slowly to a plateau at 12 hours.
hours and then declines slowly to a plateau at 12 hours.Two exponential curves may be constructed from the serum turnover curve: (1) An early
phase of tissue distribution and binding with a half-time of 100 minutes and (2) a
late dominant curve of metabolism and excretion with a halftime of 38 hours.
The dominant turnover time is similar to that observed with intravenous and intramuscular
studies, but differences are noted in the early phase. The serum concentration was
lower than that found after the intravenous route and greater than after the oral
route.
After seven days, 50 per cent of the administered dose appeared in the urine and 10
per cent in the stool.
Minor local reaction at the injection sites was noted in each patient studied.
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References
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- Studies with tritiated digoxin in renal failure.Am. J. Med. 1964; 37: 536
- Blood level studies of C14-digitoxin in human subjects with cardiac failure.J. Pharmacol. & Exper. Therap. 1955; 133: 376
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- Studies with radioactive digitalis.J. Am. Geriatric Soc. 1957; 5: 163
- Intramuscular administration of digoxin in propylene glycol.in: ed. 4. Proc. Soc. Exper. Biol. & Med.95. 1957: 349
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Article Info
Publication History
with the technical assistance of Jacquelyn Gammill, M.T. and Joyce Sherwood, M.T.
Footnotes
☆This work was supported in part by grants HE-06642 and C-47 from U. S. Public Health Service and a grant from Burroughs-Wellcome & Co. (U.S.A.), Inc., Tuckahoe, N. Y.
Identification
Copyright
© 1965 Published by Elsevier Inc.
