Early effects of digitalis on central hemodynamics in normal subjects

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      The intravenous administration of lanatoside C in 7 normal subjects had the following effects:
      • 1.
        1. An early significant reduction of heart rate.
      • 2.
        2. A significant transient reduction of cardiac output.
      • 3.
        3. A significant increase of the stroke volume initially accompanied by a significant rise of the end-diastolic volume with unchanged systolic rate of emptying. The increase of end-diastolic volume seems to be related to the lengthening of the diastolic filling period. Later on, the systolic emptying rate increases, and the ventricular volumes decrease, suggesting an inotropic effect of the drug.
      • 4.
        4. A significant increase of pulmonary blood volume, parallel to the increase of the stroke volume, suggestive of a passive relation between the two variables.
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