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Early effects of digitalis on central hemodynamics in normal subjects

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      Abstract

      The intravenous administration of lanatoside C in 7 normal subjects had the following effects:
      • 1.
        1. An early significant reduction of heart rate.
      • 2.
        2. A significant transient reduction of cardiac output.
      • 3.
        3. A significant increase of the stroke volume initially accompanied by a significant rise of the end-diastolic volume with unchanged systolic rate of emptying. The increase of end-diastolic volume seems to be related to the lengthening of the diastolic filling period. Later on, the systolic emptying rate increases, and the ventricular volumes decrease, suggesting an inotropic effect of the drug.
      • 4.
        4. A significant increase of pulmonary blood volume, parallel to the increase of the stroke volume, suggestive of a passive relation between the two variables.
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      References

        • McMichael J.
        • Sharpey-Schaper E.P.
        The action of intravenous digoxin in man.
        Quart. J. Med. 1944; 13: 123
        • Lagerlöf H.
        • Werkö L.
        Studies on the circulation in man; the effect of Cedilanid (lanatoside C) on cardiac output and blood pressure in the pulmonary circulation in patients with compensated heart disease.
        Acta cardiol. 1949; 4: 1
        • Ahmed S.
        • Bayliss R.I.S.
        • Briscoe W.A.
        • McMichael J.
        Action of ouabain (g-strophanthin) on the circulation in man, and comparison with digoxin.
        Clin. Sc. 1950; 9: 1
        • Bing R.J.
        • et al.
        Effect of strophanthus on coronary blood flow and cardiac oxygen consumption of normal and failing human hearts.
        Circulation. 1950; 2: 513
        • Harvey R.M.
        • Ferrer M.I.
        • Cathcart R.T.
        • Richards Jr., D.W.
        • Cournand A.
        Some effects of digoxin upon the heart and circulation in man; digoxin in left ventricular failure.
        Am. J. Med. 1949; 7: 439
        • Ferrer M.I.
        • Conroy K.J.
        • Harvey R.M.
        Some effects of digoxin upon the heart and circulation in man; digoxin in combined (left and right) ventricular failure.
        Circulation. 1960; 21: 372
        • Ferrer M.I.
        • et al.
        Some effects of digoxin upon the heart and circulation in man; digoxin in chronic cor pulmonale.
        Circulation. 1950; 1: 161
        • Stewart H.J.
        • Cohn A.E.
        Studies on the effect of the action of digitalis on the output of blood from the heart. III. Part 1. The effect on the output in normal human hearts. Part 2. The effect on the output of hearts in heart failure with congestion, in human beings.
        J. Clin. Invest. 1932; 11: 917
        • Harrison T.R.
        • Leonard B.W.
        The effect of digitalis on the cardiac output of dogs and its bearing on the action of the drug in heart disease.
        J. Clin. Invest. 1926; 3: 1
        • Harvey M.R.
        • Ferrer M.I.
        • Cathcart R.T.
        • Alexander J.K.
        Some effects of digoxin on the heart and circulation in man; digoxin in enlarged hearts not in clinical congestive failure.
        Circulation. 1951; 4: 366
        • Selzer A.
        • Hultgren H.N.
        • Ebnother C.L.
        • Bradley H.W.
        • Stone A.O.
        Effect of digoxin on the circulation in normal man.
        Brit. Heart J. 1959; 21: 335
        • Dresdale D.T.
        • Yuceoglu Y.Z.
        • Michtom R.J.
        • Schultz M.
        • Lunger M.
        Effects of lanatoside C on cardiovascular hemodynamics; acute digitalizing doses in subjects with normal hearts and with heart disease without failure.
        Am. J. Cardiol. 1959; 4: 88
        • Cotten M. de V.
        • Stopp P.E.
        Action of digitalis on the nonfailing heart of the dog.
        Am. J. Physiol. 1958; 192: 114
        • Braunwald E.
        • Bloodwell R.D.
        • Goldberg L.I.
        • Morrow A.G.
        Studies on digitalis. IV. Observations in man on the effects of digitalis preparations on the contractility of the non-failing heart and on total vascular resistance.
        J. Clin. Invest. 1961; 40: 52
        • Donato L.
        • et al.
        Quantitative radiocardiography. I. Theoretical considerations.
        Circulation. 1962; 26: 174
        • Donato L.
        Selective quantitative radiocardiography.
        Progr. Cardiovas. Dis. 1962; 5: 1
        • Donato L.
        • et al.
        Quantitative radiocardiography. II. Technic and analysis of curves.
        Circulation. 1962; 26: 183
        • Lewis M.L.
        • Giuntini C.
        • Donato L.
        • Harvey R.M.
        • Cournand A.
        Quantitative radiocardiography. III. Results and validation of theory and method.
        Circulation. 1962; 26: 189
        • Mannelli I.
        • Donato L.
        The periodic integrator: An instrument for recording rapid variations of counting rate.
        J. Appl. Rad. Isotopes. 1962; 13: 582
        • Chaplin H.
        • Mollison P.L.
        • Vetter H.
        The body/venous hematocrit ratio: Its constancy over a wide hematocrit range.
        J. Clin. Invest. 1953; 32: 1309
        • Freis E.D.
        • Rivara G.L.
        • Gilmore B.L.
        Estimation of residual and end-diastolic volume of the right ventricle of men without heart disease using the dye dilution method.
        Am. Heart J. 1960; 60: 898
        • Giuntini C.
        • Lewis M.L.
        • Sales Luis A.
        • Harvey R.M.
        A study of the pulmonary blood volume in man by quantitative radiocardiography.
        J. Clin. Invest. 1963; 42: 1589
        • Milnor W.R.
        • Jose A.D.
        • McGaff C.J.
        Pulmonary vascular volume, resistance and compliance in man.
        Circulation. 1960; 22: 130
        • Dock D.S.
        • et al.
        The pulmonary blood volume in man.
        J. Clin. Invest. 1961; 40: 317
        • Varnauskas E.
        • Forsberg S.Å.
        • Widimsky J.
        • Paulin S.
        Pulmonary blood volume and its relation to pulmonary hemodynamics in cardiac patients.
        Acta med. scandinav. 1963; 173: 529
        • Snedecor G.W.
        Statistical Methods.
        in: The Iowa State University Press, Iowa City, Iowa1956 (Chapters 10 and 11)
        • Williams Jr., M.H.
        • Zohman L.R.
        • Ratner A.C.
        Hemodynamic effects of cardiac glycosides on normal human subjects during rest and exercise.
        J. Appl. Physiol. 1958; 13: 417
        • Greene M.A.
        • Gordon A.
        • Boltax A.J.
        Effect of intravenous lanatoside C upon cardiodynamics in patients with mitral stenosis and regular sinus rhythm.
        Am. Heart J. 1961; 61: 622
        • Rodman T.
        • Gorczyca C.A.
        • Pastor B.H.
        The effect of digitalis on the cardiac output of the normal heart at rest and during exercise.
        Ann. Int. Med. 1961; 55: 620
        • Katz L.N.
        • Rodbard S.
        • Friend M.
        • Rottersman W.
        Effect of digitalis on the anesthetized dog. I. Action on the splanchnic bed.
        J. Pharmacol. & Exper. Therap. 1938; 62: 1
        • Baschieri L.
        • Ricci P.D.
        • Mazzuoli G.F.
        • Vassalle M.
        Studi sulla portata epatica dell'uomo; modificazioni del flusso epatico da digitale.
        Cuore e Circolaz. 1957; 41: 103
        • Ross Jr., J.
        • Waldhausen J.A.
        • Braunwald E.
        Studies on digitalis. II. Extracardiac effect on venous return and on the capacity of the peripheral vascular bed.
        J. Clin. Invest. 1960; 39: 937
        • Rushmer R.F.
        Constancy of stroke volume in ventricular responses to exertion.
        Am. J. Physiol. 1959; 196: 745
        • Warner H.D.
        • Toronto A.F.
        Regulation of cardiac output through stroke volume.
        Circulation Res. 1960; 8: 549
        • Miller D.E.
        • Gleason W.L.
        • Whalen R.E.
        • Morris Jr., J.J.
        • McIntosh H.D.
        Effect of ventricular rate on the cardiac output in the dog with chronic heart block.
        Circulation Res. 1962; 10: 658
        • Bristow J.D.
        • Ferguson R.E.
        • Mintz F.
        • Rapaport E.
        The influence of heart rate on left ventricular volume in dogs.
        J. Clin. Invest. 1963; 42: 649
      1. Donato, L., Bianchi, R., Maseri, A., Toni, P. and Giustt, C. The pulmonary blood volume in normal man determined by quantitative radiocardiography. In preparation.

        • Kim Y.S.
        • Aviado D.M.
        Digitalis and the pulmonary circulation.
        Am. Heart J. 1961; 62: 680