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Abstract
Hydralazine remains one of the most interesting and valuable hypotensive agents available.
Having both a central and a peripheral action, it provides uniform lowering of the
blood pressure. Potentiation of its hypotensive action by concomitant use of thiazide
diuretics is an additional desirable property that makes it useful in the treatment
of hypertension despite the varied side effects that may accompany its use. The exacerbation
of coronary insufficiency concomitant with its use contraindicates the prescription
of hydralazine for patients with symptomatic coronary disease. The delayed and serious
“collagenlike” syndromes that occasionally occur during hydralazine therapy are less
frequently seen with smaller doses of the drug than with the larger doses formerly
used; more recent work suggests that regression of the syndrome after cessation of
hydralazine therapy may be prolonged.
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© 1962 Published by Elsevier Inc.
