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Pharmacology and metabolism of norepinephrine in patients with essential hypertension

  • Stanley E. Gitlow
    Affiliations
    From the Department of Medicine and the Andre Meyer Department of Physics, The Mount Sinai Hospital, and the Department of Psychiatry and Neurology, New York University Medical Center, New York, New York, USA
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  • Milton Mendlowitz
    Affiliations
    From the Department of Medicine and the Andre Meyer Department of Physics, The Mount Sinai Hospital, and the Department of Psychiatry and Neurology, New York University Medical Center, New York, New York, USA
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  • Alfred Smith
    Affiliations
    From the Department of Medicine and the Andre Meyer Department of Physics, The Mount Sinai Hospital, and the Department of Psychiatry and Neurology, New York University Medical Center, New York, New York, USA
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  • Elmer Gall
    Affiliations
    From the Department of Medicine and the Andre Meyer Department of Physics, The Mount Sinai Hospital, and the Department of Psychiatry and Neurology, New York University Medical Center, New York, New York, USA
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  • Robert L. Wolf
    Affiliations
    From the Department of Medicine and the Andre Meyer Department of Physics, The Mount Sinai Hospital, and the Department of Psychiatry and Neurology, New York University Medical Center, New York, New York, USA
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  • Nosrat E. Naftchi
    Affiliations
    From the Department of Medicine and the Andre Meyer Department of Physics, The Mount Sinai Hospital, and the Department of Psychiatry and Neurology, New York University Medical Center, New York, New York, USA
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      Abstract

      • 1.
        1. The relationship of norepinephrine to essential hypertension was reviewed.
      • 2.
        2. The metabolism of H3-labelled norepinephrine was studied in normal subjects and in patients with essential hypertension.
      • 3.
        3. No difference in plasma concentration and urinary excretion of H3-labelled metabolites was demonstrated between the two groups in this study, but further investigations are in progress.
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