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Abstract
- 1.1. The relationship of norepinephrine to essential hypertension was reviewed.
- 2.2. The metabolism of H3-labelled norepinephrine was studied in normal subjects and in patients with essential hypertension.
- 3.3. No difference in plasma concentration and urinary excretion of H3-labelled metabolites was demonstrated between the two groups in this study, but further investigations are in progress.
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References
- Physiological effects of the suprarenal capsules.J. Physiol. 1895; 18: 230
- Die Erkrankungen der Nebennieren.Nothnagel's Specielle Pathologie und Therapie, Vienna. 1897; 18: 71
- Hypertension.in: Rap. Cong. franç, de méd.7. 1904: 338
- La pharmacologie du système nerveux autonome et particulièrement du sympathique, d'après la théorie neuro-humorale.Ann. de physiol. 1934; 10: 467
- Nor-epinephrine as a possible mediator in the sympathetic division of the autonomie nervous system.J. Pharmacol. & Exper. Therap. 1938; 62: 189
- Dihydroxyphenylethanolamine (arterenol) as a possible sympathetic hormone.J. Pharmacol. & Exper. Therap. 1937; 59: 114
- On the action of adrenalin.J. Physiol. 1904; 31: 20P
- Über humorale Überträgbarkeit der Herznervenwirkung.Arch. ges. Physiol. 1921; 189: 239
- Studies on the conditions of activity in endocrine glands, VI. Further observations on the denervated heart in relation to adrenal secretion.Am. J. Physiol. 1922; 58: 308
- The presence of a substance with sympathin E properties in spleen extracts.Acta physiol. scandinav. 1946; 11: 168
- A specific sympathomimetic ergone in adrenergic nerve fibers (sympathin) and its relation to adrenaline and noradrenaline.Acta physiol. scandinav. 1946; 12: 73
- The nature of the peripheral resistance in arterial hypertension with special reference to the vasomotor system.J. Clin. Invest. 1936; 15: 63
- Nature of peripheral resistance in essential hypertension.J. Clin. Invest. 1940; 19: 25
- The hemodynamic response of man to norepinephrine and epinephrine and its relation to the problem of hypertension.Am. J. Med. 1948; 5: 792
- Über das sympathicomimetische pressorische Prinzip des Harns (“Urosympathin”).Arch. Exper. Path, u. Pharmakol. 1947; 204: 228
- On certain points in the anatomy and pathology of Bright's disease of the kidney II On the influence of the minute blood vessels upon the circulation.in: Med.-Chir. Tr.51. 1868: 57
- The etiology of hypertension.J. Mt. Sinai Hosp. 1961; 28: 101
- Noradrenaline output in urine after infusion in man.Brit. J. Pharmacol. 1951; 6: 286
- The diagnosis of pheochromocytoma by determination of urinary 3- methoxy, 4-hydroxymandelic acid.J. Clin. Invest. 1960; 39: 221
- The diagnosis of pheochromocytoma.J. Mt. Sinai Hasp. 1961; 28: 159
- Noradrenaline. Chemistry, Physiology, Pharmacology, and Clinical Aspects.Charles C Thomas, Springfield, Ill1956
- Chemical Quantitation of Epinephrine and Norepinephrine in Plasma.Charles C Thomas, Springfield, Ill1959
- Chemical screening methods for the diagnosis of pheochromocytoma. I. Norepinephrine and epinephrine in human urine.Am. J. Med. 1954; 16: 310
- Some aspects of the clinical physiology of noradrenaline.Scandinav. J. Clin. & Lab. Invest. 1952; 4: 254
- The estimation of noradrenaline in urine and its excretion in normal and hypertensive subjects.J. Clin. Path. 1957; 10: 120
- Blood pressure and urinary excretion of noradrenaline (NA).Scandinav. J. of Clin. & Lab. Invest. 1957; 9: 331
Cohen, G., Laragh, J. and Goldenberg, M. Unpublished observations.
- Diagnosis of pheochromocytoma by assay of catecholamine metabolites.Circulation Res. 1961; 9: 746
- The comparative effects of small intravenous doses of l-norepinephrine upon arterial pressure and pulse rate in normotensive subjects and in hypertensive patients before and after thoracolumbar sympathectomy.J. Clin. Invest. 1950; 29: 1414
- Peripheral vascular hemodynamics in the bulbar conjunctiva of subjects with hypertensive vascular disease.J. Clin. Invest. 1951; 30: 539
- Hemodynamic changes in the bulbar conjunctival capillary bed of subjects with hypertension associated with “Cushing's syndrome” or pheochromocytoma.Am. J. Med. 1955; 19: 203
- The reactivity of the capillary bed of the nailfold to circulating epinephrine and norepinephrine in patients with normal blood pressure and with essential hypertension.J. Clin. Invest. 1952; 31: 782
- Reactivity to pressor agents in hypertension.Circulation. 1955; 12: 974
- Reactivity of forearm vessels to vasoconstrictor substances in hypertensive and normotensive subjects.Clin. Sc. 1959; 18: 441
- Force and work of digital arteriolar smooth muscle contraction in hypertension.J. Appl. Physiol. 1957; 10: 436
- Work of digital vasoconstriction produced by infused norepinephrine in primary hypertension.J. Appl. Physiol. 1958; 13: 247
- Identification of a major urinary metabolite of norepinephrine.in: Fed. Proc.16. 1957: 146
- O-methylation of epinephrine and other catechols in vitro and in vivo.Science. 1957; 126: 400
- Metabolism of dl-adrenaline-2-C14 in the human.in: Proc. Soc. Exper. Biol. & Med.98. 1958: 627
- The oxidation of adrenaline and other amines.Biochem. J. 1937; 31: 2187
- 3-Methoxy-4-hydroxy-d-mandelic acid, a urinary metabolite of norepinephrine.Biochim. et biophys. acta. 1957; 25: 422
- Amine oxidases. XI Inhibition of monamine oxidase by 1-isonicotinyl-2-isopropylhydrazine.J. Biol. Chem. 1955; 214: 267
- Effect of iproniazid on digital vascular norepinephrine sensitivity.in: Moyer J.H. Hypertension, The First Hahnemann Symposium on Hypertensive Disease. W. B. Saunders Co, Philadelphia and London1959: 409
- Relative lack of pharmacological action of the 3-methoxy analogue of norepinephrine.in: Proc. Soc. Exper. Biol. & Med.98. 1958: 74
- Metabolism of dl-β-H3-norepinephrine in the human subject.Clin. Res. 1960; 8: 365
- The dynamics of norepinephrine metabolism.in: Brest A.N. Moyer J.H. Hypertension, Recent Advances. Lea & Febiger, Philadelphia1961: 335
- Metabolic pathways of 3-hydroxytyramine.Biochim. et biophys. acta. 1959; 33: 572
- The physiological disposition of H3-epinephrine and its metabolite metanephrine.J. Pharmacol. & Exper. Therap. 1959; 127: 251
- Elimination of adrenaline and noradrenaline from the organism.Acta pharmacol. et toxicol. 1951; 7: 297
- Reactivity of the digital blood vessels to angiotensin II in normotensive and hypertensive subjects.Am. Heart J. 1961; 62: 221
- Metabolism of angiotensin II-I131 in normotensive and hypertensive human subjects.Circulation. 1961; 23: 754
Article Info
Footnotes
☆Aided by grants from the American Heart Association, The National Heart Institute (H1164) (H6546) (Cardio) and The National Institute of Mental Health (M1434).
Identification
Copyright
© 1962 Published by Elsevier Inc.