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Circulating epinephrine and norepinephrine in coronary occlusion

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      Abstract

      • 1.
        1. Following experimental coronary occlusion in thirty-nine dogs, mean values of norepinephrine increased maximally from 1.6 to 10.5 μg-/L. of plasma in thirty-three surviving animals. Serum transaminase increments paralleled norepinephrine elevations in most instances. No changes occurred in circulating levels of epinephrine. Recordings of fluorescence emission spectrums aided in the identification and quantitation of the catecholamines.
      • 2.
        2. Essentially the same results occurred in four chronically adrenalectomized dogs.
      • 3.
        3. Following coronary occlusion and the administration of a sympatholytic agent (tri-methyl-2-2,6 xylyloxy-propyl ammonium chloride monohydrate), elevated circulating levels of norepinephrine declined progressively to pre-occlusion figures.
      • 4.
        4. Of eighteen dogs treated with reserpine, eleven survived the occlusive procedure and showed increments in norepinephrine and transaminase similar to those of the untreated animals,
      • 5.
        5. The catecholamine content of the infarct and the adjacent area was not elevated above the values found in normal tissue.
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