- 1.1. It has been observed that rabbits maintained on a high fat-cholesterol diet for periods ranging up to thirty-eight weeks, show no significant anoxic electrocardiographic changes (STT alterations) as compared with normal rabbits.
- 2.2. Following injections of epinephrine in doses ranging from 100 to 500 μg, marked ventricular arrhythmias and even fatal ventricular fibrillation ensue in both normal and high fat-fed animals, although no significant ST-T changes were detectable.
- 3.3. Following the injection of norepinephrine in doses of 100 and 200 μg., tachycardias of various types ensued only in fat-fed animals, but with higher doses (500 and 1,000 μg.) similar changes occurred in both normal and fat-fed animals.
- 4.4. Norepinephrine under these conditions induces rather characteristic anoxic ST-T changes, but no ventricular fibrillation.
- 5.5. Perfused isolated atherosclerotic hearts show diminished contractility and reduced responses to epinephrine and norepinephrine.
- 6.6. It is concluded, therefore, that norepinephrine is less injurious than epinephrine to both the normal and the atherosclerotic heart.
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☆From the Department of Pharmacology, McGill University, Montreal, Canada.