Cardiac responses to epinephrine and norepinephrine during prolonged cholesterol and high fat feeding in rabbits

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      • 1.
        1. It has been observed that rabbits maintained on a high fat-cholesterol diet for periods ranging up to thirty-eight weeks, show no significant anoxic electrocardiographic changes (STT alterations) as compared with normal rabbits.
      • 2.
        2. Following injections of epinephrine in doses ranging from 100 to 500 μg, marked ventricular arrhythmias and even fatal ventricular fibrillation ensue in both normal and high fat-fed animals, although no significant ST-T changes were detectable.
      • 3.
        3. Following the injection of norepinephrine in doses of 100 and 200 μg., tachycardias of various types ensued only in fat-fed animals, but with higher doses (500 and 1,000 μg.) similar changes occurred in both normal and fat-fed animals.
      • 4.
        4. Norepinephrine under these conditions induces rather characteristic anoxic ST-T changes, but no ventricular fibrillation.
      • 5.
        5. Perfused isolated atherosclerotic hearts show diminished contractility and reduced responses to epinephrine and norepinephrine.
      • 6.
        6. It is concluded, therefore, that norepinephrine is less injurious than epinephrine to both the normal and the atherosclerotic heart.
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