| Cardiomyopathy |
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Eugene Braunwald, MD and the Early Years of Hypertrophic Cardiomyopathy: A Conversation With Dr. Barry J. Maron
19 March 2012
There is some uncertainty, and even controversy, as to when hypertrophic cardiomyopathy was first recognized. Dating back to 1868, there are autopsy-based case reports from France, Germany, and the Un...
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Barry J. Maron,
Eugene Braunwald
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1539-1547
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| Coronary Artery Disease |
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Influence of Diabetes Mellitus on Long-Term (Five-Year) Outcomes of Drug-Eluting Stents and Coronary Artery Bypass Grafting for Multivessel Coronary Revascularization
19 March 2012
Diabetes mellitus is a major risk factor for coronary artery disease (CAD) and for diffuse and progressive atherosclerosis. We evaluated the outcomes of drug-eluting stent (DES) placement and coronary...
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Yong-Giun Kim,
Duk-Woo Park,
Woo Seok Lee,
Gyung-Min Park,
Byung Joo Sun,
Chang Hoon Lee,
Ki Won Hwang,
Sung Won Cho,
Yoo Ri Kim,
Hae Geun Song,
Jung-Min Ahn,
Won-Jang Kim,
Jong-Young Lee,
Soo-Jin Kang,
Seung-Whan Lee,
Young-Hak Kim,
Cheol Whan Lee,
Seong-Wook Park,
Seungbong Han,
Sung-Ho Jung,
Suk Jung Choo,
Cheol Hyun Chung,
Jae-Won Lee,
Seung-Jung Park
et al.
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1548-1557
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Relation of Routine, Periodic Fasting to Risk of Diabetes Mellitus, and Coronary Artery Disease in Patients Undergoing Coronary Angiography
19 March 2012
Previously we discovered that routine periodic fasting was associated with a lower prevalence of coronary artery disease (CAD). Other studies have shown that fasting increases longevity in animals. A ...
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Benjamin D. Horne,
Joseph B. Muhlestein,
Heidi T. May,
John F. Carlquist,
Donald L. Lappé,
Tami L. Bair,
Jeffrey L. Anderson,
Intermountain Heart Collaborative Study Group
et al.
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1558-1562
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Comparison of Late (3-Year) Registry Data Outcomes Using Bare Metal Versus Drug-Eluting Stents for Treating ST-Segment Elevation Acute Myocardial Infarctions
22 March 2012
Clinical trial data have supported the safety and efficacy of drug-eluting stents (DES) in the treatment of patients with ST-segment elevation myocardial infarctions (STEMIs), but contemporary “real-w...
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Abid Assali,
Muthiah Vaduganathan,
Hanna Vaknin-Assa,
Eli I. Lev,
David Brosh,
Igal Teplitsky,
Tamir Bental,
Alexander Battler,
Ran Kornowski
et al.
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1563-1568
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Comparison of Frail Patients Versus Nonfrail Patients ≥65 Years of Age Undergoing Percutaneous Coronary Intervention
22 March 2012
Frailty is a geriatric syndrome characterized by functional impairments and is associated with poor outcomes; however, the prevalence of frailty and its association with health status in patients trea...
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S. Michael Gharacholou,
Veronique L. Roger,
Ryan J. Lennon,
Charanjit S. Rihal,
Jeff A. Sloan,
John A. Spertus,
Mandeep Singh
et al.
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1569-1575
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Intravascular Ultrasound Findings That Are Predictive of No Reflow After Percutaneous Coronary Intervention for Saphenous Vein Graft Disease
22 March 2012
The aim of this study was to investigate the relation between intravascular ultrasound (IVUS) findings and the no-reflow phenomenon and long-term outcome after percutaneous coronary intervention (PCI)...
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Young Joon Hong,
Myung Ho Jeong,
Youngkeun Ahn,
Jung Chaee Kang,
Gary S. Mintz,
Sang Wook Kim,
Sung Yun Lee,
Seok Yeon Kim,
Augusto D. Pichard,
Lowell F. Satler,
Ron Waksman,
Neil J. Weissman
et al.
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1576-1581
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Are the Results of a Regional ST-Elevation Myocardial Infarction System Reproducible?
22 March 2012
Primary percutaneous coronary intervention (PCI) is the preferred reperfusion method in patients with ST-elevation myocardial infarction (STEMI) if it can be performed in a timely manner in high-volum...
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Lindsay G. Smith,
Sue Duval,
Mark A. Tannenbaum,
Susan Johnson Brown,
Anil K. Poulose,
Liberato A. Iannone,
David M. Larson,
Magdi G.H. Ghali,
Timothy D. Henry
et al.
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1582-1588
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Recent Trends in Hospitalization for Acute Myocardial Infarction
22 March 2012
Rates of acute myocardial infarction (AMI) hospitalizations for elderly Medicare patients decreased during the previous decade. However, trends in population rates of AMI hospitalizations for all adul...
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Oliver J. Wang,
Yongfei Wang,
Jersey Chen,
Harlan M. Krumholz
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1589-1593
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Within-Hospital and 30-Day Outcomes in 107,994 Patients Undergoing Invasive Coronary Angiography With Different Low-Osmolar Iodinated Contrast Media
22 March 2012
Comparative clinical outcomes after exposure to alternate low osmolar contrast media (LOCM) during invasive coronary angiography (ICA) and/or percutaneous coronary intervention (PCI) have been incompl...
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Troy M. LaBounty,
Manan Shah,
Subha V. Raman,
Fay Y. Lin,
Daniel S. Berman,
James K. Min
et al.
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1594-1599
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Comparison of Two- and Three-Dimensional Quantitative Coronary Angiography to Intravascular Ultrasound in the Assessment of Intermediate Left Main Stenosis
19 March 2012
Angiographic evaluation of intermediate left main coronary artery stenosis (LMS) is often limited. Three-dimensional (3D) quantitative coronary angiography has recently developed to overcome 2-dimensi...
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Italo Porto,
Ilaria Dato,
Daniel Todaro,
Michele Calabrese,
Stefano Rigattieri,
Antonio Maria Leone,
Giampaolo Niccoli,
Francesco Burzotta,
Carlo Trani,
Filippo Crea
et al.
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1600-1607
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| Preventive Cardiology |
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Meta-Analysis of Dietary Glycemic Load and Glycemic Index in Relation to Risk of Coronary Heart Disease
22 March 2012
A high glycemic diet may increase cardiovascular risk, yet whether the risk differs by gender or adiposity is inconclusive. Our goal was to determine the associations between dietary glycemic load (GL...
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Jia-Yi Dong,
Yong-Hong Zhang,
Peiyu Wang,
Li-Qiang Qin
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1608-1613
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| Arrhythmias and Conduction Disturbances |
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Effectiveness of Sotalol as First-Line Therapy for Fetal Supraventricular Tachyarrhythmias
26 March 2012
Fetal supraventricular tachycardia (SVT) and atrial flutter (AF) can be associated with significant morbidity and mortality. Digoxin is often used as first-line therapy but can be ineffective and is p...
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Amee Shah,
Anita Moon-Grady,
Neil Bhogal,
Kathryn K. Collins,
Theresa Tacy,
Michael Brook,
Lisa K. Hornberger
et al.
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1614-1618
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| Heart Failure |
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Relation of Dosing of the Renin–Angiotensin System Inhibitors After Cardiac Resynchronization Therapy to Long-Term Prognosis
02 April 2012
Dosing of angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) in patients with heart failure (HF) treated with cardiac resynchronization therapy (CRT) may affect lo...
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Lilian Mantziari,
Kaushik Guha,
Zohya Khalique,
Theresa McDonagh,
Rakesh Sharma
et al.
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1619-1625
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| Valvular Heart Disease |
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Comparison of Left Ventricular Outflow Geometry and Aortic Valve Area in Patients With Aortic Stenosis by 2-Dimensional Versus 3-Dimensional Echocardiography
22 March 2012
The present study sought to elucidate the geometry of the left ventricular outflow tract (LVOT) in patients with aortic stenosis and its effect on the accuracy of the continuity equation-based aortic ...
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Takeji Saitoh,
Maiko Shiota,
Masaki Izumo,
Swaminatha V. Gurudevan,
Kirsten Tolstrup,
Robert J. Siegel,
Takahiro Shiota
et al.
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1626-1631
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Frequency of Congenitally Bicuspid Aortic Valves in Patients ≥80 Years of Age Undergoing Aortic Valve Replacement for Aortic Stenosis (With or Without Aortic Regurgitation) and Implications for Transcatheter Aortic Valve Implantation
29 March 2012
The purpose of the present report was to determine the frequency of a congenitally bicuspid aortic valve in patients ≥80 years of age old with aortic stenosis (AS) severe enough to warrant aortic valv...
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William Clifford Roberts,
Kaitlin Georgeanne Janning,
Jong Mi Ko,
Giovanni Filardo,
Gregory John Matter
et al.
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1632-1636
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Frequency and Causes of Stroke During or After Transcatheter Aortic Valve Implantation
19 March 2012
Transcatheter aortic valve implantation (TAVI) is invariably associated with the risk of clinically manifest transient or irreversible neurologic impairment. We sought to investigate the incidence and...
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Rutger-Jan Nuis,
Nicolas M. Van Mieghem,
Carl J. Schultz,
Adriaan Moelker,
Robert M. van der Boon,
Robert Jan van Geuns,
Aad van der Lugt,
Patrick W. Serruys,
Josep Rodés-Cabau,
Ron T. van Domburg,
Peter J. Koudstaal,
Peter P. de Jaegere
et al.
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1637-1643
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| Cardiomyopathy |
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A Novel Titin Mutation in Adult-Onset Familial Dilated Cardiomyopathy
05 April 2012
Familial dilated cardiomyopathy is a major cause of advanced heart failure and heart transplantation. In most families, the disease-causing mutation is unknown, and relatives should therefore undergo ...
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Guy Yoskovitz,
Yael Peled,
Michael Gramlich,
Hadas Lahat,
Heike Resnik-Wolf,
Micha S. Feinberg,
Arnon Afek,
Elon Pras,
Michael Arad,
Brenda Gerull,
Dov Freimark
et al.
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1644-1650
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Usefulness of Sum of ST-Segment Elevation on Electrocardiograms (Limb Leads) for Predicting In-Hospital Complications in Patients With Stress (Takotsubo) Cardiomyopathy
22 March 2012
Although the prognosis of patients with stress (takotsubo) cardiomyopathy is relatively favorable, serious complications occur in some patients. It is generally accepted that electrocardiography is an...
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Seiji Takashio,
Megumi Yamamuro,
Sunao Kojima,
Yasuhiro Izumiya,
Koichi Kaikita,
Seiji Hokimoto,
Seigo Sugiyama,
Ryusuke Tsunoda,
Koichi Nakao,
Hisao Ogawa
et al.
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1651-1656
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| Congenital Heart Disease |
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Social Burden and Lifestyle in Adults With Congenital Heart Disease
26 March 2012
We aimed to evaluate how the presence and severity of congenital heart disease (CHD) influence social life and lifestyle in adult patients. A random sample (n = 1,496) from the CONgenital CORvitia (n ...
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A. Carla Zomer,
Ilonca Vaartjes,
Cuno S.P. Uiterwaal,
Enno T. van der Velde,
Gert-Jan T. Sieswerda,
Elly M.C. Wajon,
Koos Plomp,
Paul F.M. van Bergen,
Carianne L. Verheugt,
Eva Krivka,
Cees J. de Vries,
Dirk J.A. Lok,
Diederick E. Grobbee,
Barbara J.M. Mulder
et al.
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1657-1663
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| Miscellaneous |
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Gender and Ethnic Differences in Red Cell Distribution Width and Its Association With Mortality Among Low Risk Healthy United State Adults
19 March 2012
Limited information is available about gender and ethnic differences in red cell distribution width (RCDW) with regard to its relation to mortality in a population free of cardiovascular (CV) disease ...
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Sandip K. Zalawadiya,
Vikas Veeranna,
Sidakpal S. Panaich,
Luis Afonso,
Jalal K. Ghali
et al.
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1664-1670
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Relation of Ventricular Ectopic Complexes to QTc Interval on Ambulatory Electrocardiograms in Williams Syndrome
30 March 2012
Williams syndrome (WS) is a congenital, developmental disorder affecting 1 in 8,000 live births. The corrected QT (QTc) interval is prolonged in 13% of patients with WS. No data exist characterizing t...
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R. Thomas Collins,
Peter F. Aziz,
Christopher J. Swearingen,
Paige B. Kaplan
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1671-1676
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Recessively Inherited Severe Aortic Aneurysm Caused by Mutated EFEMP2
22 March 2012
Familial aortic aneurysm (AA) is mostly inherited as an autosomal dominant disorder. However, recessively inherited AA has also been observed but in association with skin manifestations of cutis laxa,...
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Zuhair N. Al-Hassnan,
Abdul Rahman Almesned,
Sahar Tulbah,
Ali Hakami,
Ahmed Al-Omrani,
Abdullah Al Sehly,
Shamayel Mohammed,
Salma Majid,
Brian Meyer,
Majid Al-Fayyadh
et al.
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1677-1680
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| Review |
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Clinical Implications of Cardiovascular Preventing Pleiotropic Effects of Dipeptidyl Peptidase-4 Inhibitors
19 March 2012
Dipeptidyl peptidase-4 (DPP-4) inhibitors are novel drugs for the treatment of type 2 diabetes mellitus. They exert their action through inhibition of the catabolism of locally secreted incretins such...
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Steven G. Chrysant,
George S. Chrysant
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1681-1685
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| Readers' Comments |
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Needed—Electrocardiographic Findings in Left Ventricular Noncompaction
This comment is in response to the contribution by Greutmann et al in the January 15, 2012, issue of The American Journal of Cardiology on adverse outcomes in 155 patients with isolated left ventricul...
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John E. Madias
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1686
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Authors' Reply
We wish to thank Dr. Madias for his interest in our report. With regard to electrocardiographic data, the types of bundle branch block were specified in the footnote of Table 1 (of 32 patients with bu...
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Matthias Greutmann,
Christine H. Attenhofer Josb,
Rolf Jenni,
Erwin N. Oechslin
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1686
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Thromboembolic Risk in Atrial Flutter Resembles Non-Valvular Atrial Fibrillation (Insights from Transesophageal Echocardiography)
The recently published report by Parikh et al reinforces the thromboembolic nature of atrial flutter. The described prevalence of left atrial (LA) thrombi and spontaneous echocardiographic contrast (S...
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Rui Providência
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1686-1687
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Cardiovascular Death and Cancer Death—Competing Risk?
Drs. Nabel and Braunwald have elegantly illustrated in their Figure 1 that preventive and therapeutic strategies substantially reduced risk for cardiovascular death. In contrast, the death rate from c...
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Franz H. Messerli,
Sripal Bangalore
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1687
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| Erratum |
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Erratum for Ito et al. “Comparison of Patients With Pulmonary Arterial Hypertension With Versus Without Right-Sided Mechanical Alternans” Am J Cardiol 2012;109:428–431
The wording of the second and third column headings in was incorrect. The second column heading should have read “No Alternans (n = 24)” and the third column heading should have read “Alternans (n = ...
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1687
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| Frontmatter |
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Editorial Board
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A5
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Contents
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A7
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