Serial volumetric intravascular ultrasound assessment of arterial remodeling in left main coronary artery disease

Shiran, Avinoam; Mintz, Gary S.; Leiboff, Borjanca; Kent, Kenneth M.; Pichard, Augusto D.; Satler, Lowell F.; Kimura, Takeshi; Nobuyoshi, Masakiyo; Leon, Martin B.

« Previous Next »American Journal of Cardiology
Volume 83, Issue 10 , Pages 1427-1432, 15 May 1999

Serial volumetric intravascular ultrasound assessment of arterial remodeling in left main coronary artery disease☆

Avinoam Shiran, MD
- Intravascular Ultrasound Imaging and Cardiac Catheterization Laboratories, Washington Hospital Center, Washington, DC., USA
Gary S. Mintz, MD
- Intravascular Ultrasound Imaging and Cardiac Catheterization Laboratories, Washington Hospital Center, Washington, DC., USA
- Address for reprints: Gary S. Mintz, MD, Cardiology Research Foundation, 110 Irving Street, W-4B1, Washington, DC 20010
Borjanca Leiboff, MD
- Intravascular Ultrasound Imaging and Cardiac Catheterization Laboratories, Washington Hospital Center, Washington, DC., USA
Kenneth M. Kent, MD, PhD
- Intravascular Ultrasound Imaging and Cardiac Catheterization Laboratories, Washington Hospital Center, Washington, DC., USA
Augusto D. Pichard, MD
- Intravascular Ultrasound Imaging and Cardiac Catheterization Laboratories, Washington Hospital Center, Washington, DC., USA
Lowell F. Satler, MD
- Intravascular Ultrasound Imaging and Cardiac Catheterization Laboratories, Washington Hospital Center, Washington, DC., USA
Takeshi Kimura, MD
- Intravascular Ultrasound Imaging and Cardiac Catheterization Laboratories, Washington Hospital Center, Washington, DC., USA
Masakiyo Nobuyoshi, MD
- Intravascular Ultrasound Imaging and Cardiac Catheterization Laboratories, Washington Hospital Center, Washington, DC., USA
Martin B. Leon, MD
- Intravascular Ultrasound Imaging and Cardiac Catheterization Laboratories, Washington Hospital Center, Washington, DC., USA

published online 16 August 2004.

Abstract

Serial volumetric intravascular ultrasound (IVUS) was used to study de novo, nontreated left main coronary arteries (LMCAs) in 31 patients. Using an automated contour detection algorithm, analysis of 7.2 ± 2.5 mm long segments included arterial, lumen, and plaque volumes and plaque burden (plaque/arterial volumes). During follow-up (7.7 ± 2.4 months), the percent change in lumen volume correlated with the percent change in arterial volume (r = 0.897, p <0.0001), but not with the percent change in plaque volume (r = 0.066, p = 0.7263). Percent changes in arterial volume correlated with percent changes in plaque + media volume (r = 0.448, p = 0.0115), indicating arterial remodeling. However, there was a spectrum of responses ranging from inadequate remodeling (decrease in lumen volume despite no increase or a decrease in plaque volume: i.e., arterial shrinkage) to overcompensation (an increase in lumen volume despite an increase in plaque volume).Serial volumetric IVUS (1) confirms the existence of both positive and negative remodeling in LMCA, and (2) shows that in moderate LMCA disease, luminal changes resulted primarily from positive versus negative remodeling, not plaque progression and/or regression.

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☆ This study was supported in part by the Cardiology Research Foundation, Washington, DC. Manuscript received December 2, 1998; revised manuscript received and accepted December 23, 1998.

PII: S0002-9149(99)00119-8

« Previous Next »American Journal of Cardiology
Volume 83, Issue 10 , Pages 1427-1432, 15 May 1999

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