American Journal of Cardiology
Volume 108, Issue 6 , Pages 776-781 , 15 September 2011

System Delay and Timing of Intervention in Acute Myocardial Infarction (from the Danish Acute Myocardial Infarction-2 [DANAMI-2] Trial)

  • Peter H. Nielsen, MD

      Affiliations

    • Department of Cardiology, Aarhus University Hospital, Skejby, Denmark
    • ,
  • Christian J. Terkelsen, MD, PhD

      Affiliations

    • Department of Cardiology, Aarhus University Hospital, Skejby, Denmark
    • ,
  • Torsten T. Nielsen, MD, DMSc

      Affiliations

    • Department of Cardiology, Aarhus University Hospital, Skejby, Denmark
    • ,
  • Leif Thuesen, MD, DMSc

      Affiliations

    • Department of Cardiology, Aarhus University Hospital, Skejby, Denmark
    • ,
  • Lars R. Krusell, MD

      Affiliations

    • Department of Cardiology, Aarhus University Hospital, Skejby, Denmark
    • ,
  • Per Thayssen, MD, DMSc

      Affiliations

    • Department of Cardiology, Odense University Hospital, Odense, Denmark
    • ,
  • Henning Kelbæk, MD, DMSc

      Affiliations

    • Department of Cardiology, Gentofte University Hospital, Copenhagen, Denmark
    • ,
  • Ulrik Abildgaard, MD

      Affiliations

    • Department of Cardiology, Rigshospitalet, Copenhagen, Denmark
    • ,
  • Anton B. Villadsen, MD

      Affiliations

    • Department of Cardiology, Aarhus University Hospital, Aalborg, Denmark
    • ,
  • Henning R. Andersen, MD, DMSc

      Affiliations

    • Department of Cardiology, Aarhus University Hospital, Skejby, Denmark
    • ,
  • Michael Maeng, MD, PhD

      Affiliations

    • Department of Cardiology, Aarhus University Hospital, Skejby, Denmark
    • Corresponding Author InformationCorresponding author: Tel: (+45) 8949-5566; fax: (+45) 8949-6025
    • ,
  • Danami-2 Investigators

Received 11 February 2011 ,Accepted 9 May 2011.

References 

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  2. Brodie BR, Stuckey TD, Muncy DB, Hansen CJ, Wall TC, Pulsipher M, et al. Importance of time-to-reperfusion in patients with acute myocardial infarction with and without cardiogenic shock treated with primary percutaneous coronary intervention. Am Heart J. 2003;145:708–715
  3. De Luca G, Suryapranata H, Zijlstra F, van't Hof AW, Hoorntje JC, Gosselink AT, et al. Symptom-onset-to-balloon time and mortality in patients with acute myocardial infarction treated by primary angioplasty. J Am Coll Cardiol. 2003;42:991–997
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  10. Nallamothu BK, Bates ER. Percutaneous coronary intervention versus fibrinolytic therapy in acute myocardial infarction: is timing (almost) everything?. Am J Cardiol. 2003;92:824–826
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  14. Andersen HR, Nielsen TT, Rasmussen K, Thuesen L, Kelbaek H, Thayssen P, et al. A comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction. N Engl J Med. 2003;349:733–742
  15. Andersen HR, Nielsen TT, Vesterlund T, Grande P, Abildgaard U, Thayssen P, et al. Danish multicenter randomized study on fibrinolytic therapy versus acute coronary angioplasty in acute myocardial infarction: rationale and design of the Danish trial in Acute Myocardial Infarction-2 (DANAMI-2). Am Heart J. 2003;146:234–241
  16. Maeng M, Nielsen PH, Busk M, Mortensen LS, Kristensen SD, Nielsen TT, et al. Time to treatment and three-year mortality after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction—a DANish Trial in Acute Myocardial Infarction-2 (DANAMI-2) substudy. Am J Cardiol. 2010;105:1528–1534
  17. Terkelsen CJ, Lassen JF, Norgaard BL, Gerdes JC, Poulsen SH, Bendix K, et al. Reduction of treatment delay in patients with ST-elevation myocardial infarction: impact of pre-hospital diagnosis and direct referral to primary percutaneous coronary intervention. Eur Heart J. 2005;26:770–777
  18. Nielsen PH, Maeng M, Busk M, Mortensen LS, Kristensen SD, Nielsen TT, et al. Primary angioplasty versus fibrinolysis in acute myocardial infarction: long-term follow-up in the Danish acute myocardial infarction 2 trial. Circulation. 2010;121:1484–1491
  19. Van de Werf F, Bax J, Betriu A, Blomstrom-Lundqvist C, Crea F, Falk V, et al. Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology. Eur Heart J. 2008;29:2909–2945
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  21. Kushner FG, Hand M, Smith SC, King SB, Anderson JL, Antman EM, et al. 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction (updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (updating the 2005 Guideline and 2007 Focused Update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2009;120:2271–2306
  22. Nallamothu BK, Bates ER, Wang Y, Bradley EH, Krumholz HM. Driving times and distances to hospitals with percutaneous coronary intervention in the United States: implications for prehospital triage of patients with ST-elevation myocardial infarction. Circulation. 2006;113:1189–1195

PII: S0002-9149(11)01774-7

doi: 10.1016/j.amjcard.2011.05.007

American Journal of Cardiology
Volume 108, Issue 6 , Pages 776-781 , 15 September 2011

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