American Journal of Cardiology
Volume 106, Issue 4 , Pages 587-592 , 15 August 2010

Can a Statin Neutralize the Cardiovascular Risk of Unhealthy Dietary Choices?

Received 23 December 2009 ,Revised 30 March 2010 ,Accepted 30 March 2010.

References 

  1. World Health Organization. Part 2: causes of death and part 4: burden of disease DALYs. In: Global Burden of Disease: 2004 Update. Geneva, Switzerland: World Health Organization; 2008;p. 8–26
  2. Nemetz P, Roger V, Ransom J, Bailey K, Edwards W, Leibson C. Recent trends in the prevalence of coronary disease (A population-based autopsy study of nonnatural deaths). Arch Int Med. 2008;168:264–270
  3. Rose G. Sick individuals and sick populations. Int J Epidemiol. 1985;14:32–38
  4. Schlosser E. Fast Food Nation. Boston, Massachusetts: Houghton Mifflin; 2001;
  5. Prentice AM, Jebb SA. Fast foods, energy density and obesity: a possible mechanistic link. Obes Rev. 2007;4:187–194
  6. Barratt A, Wyer PC, Hatala R, McGinn T, Dans AL, Keitz S, et al. Tips for learners of evidence-based medicine: 1. Relative risk reduction, absolute risk reduction and number needed to treat. CMAJ. 2004;171:353–358
  7. Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study). Lancet. 2004;364:937–952
  8. LaRosa JC, Grundy SM, Waters DD, Shear C, Barter P, Fruchart JC, et al. Intensive lipid lowering with atorvastatin in patients with stable coronary disease. N Engl J Med. 2005;352:1425–1435
  9. Ascherio A, Rimm EB, Spiegelman D, Stampfer M. Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States. BMJ. 1996;313:84–90
  10. Easty DL. The relationship of diet to serum cholesterol levels in young men in Antarctica. Br J Nutr. 1970;24:307–312
  11. Mente A, Koning L, Shannon H, Anand S. A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease. Arch Intern Med. 2009;169:659–669
  12. http://nutrition.mcdonalds.com/nutritionexchange/nutritionfacts.pdfAccessed July 9, 2010
  13. Thavendiranathan P, Baggi A, Brookhart A, Choudhry N. Primary prevention of cardiovascular diseases with statin therapy (A meta-analysis of randomized controlled trials). Arch Int Med. 2006;166:2307–2313
  14. Colhoun HM, Betteridge DJ, Durrington PN, Hitman GA, Neil HA, Livingstone SJ, et al. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomized placebo-controlled trial. Lancet. 2004;364:685–696
  15. Wilson PWF, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation. 1998;97:1837–1847
  16. Prospective Studies Collaboration. Blood cholesterol and vascular mortality by age, sex and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55000 vascular deaths. Lancet. 2007;370:1829–1839
  17. Neaton JD, Wentworth D Multiple Risk Factor Intervention Trial Research Group. Serum cholesterol, blood pressure, cigarette smoking and death from coronary heart disease: overall findings and differences by age for 316099 white men. Arch Int Med. 1992;152:56–64
  18. De Backer G, Ambrosioni E, Borch-Johnsen K, Brotons C, Cifkova R, Dallongeville J, et al. Executive summary: European guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2003;24:1601–1610
  19. Greenland P, Smith SC, Grundy SM. Improving coronary heart disease risk assessment in asymptomatic people (Role of traditional risk factors and noninvasive cardiovascular tests). Circulation. 2001;104:1863–1867
  20. Asia Pacific Cohort Studies Collaboration. Joint effects of systolic blood pressure and serum cholesterol on cardiovascular disease in the Asia Pacific region. Circulation. 2005;112:3384–3390
  21. Hozawa A, Folsom AR, Sharrett AR, Chambless LE. The Atherosclerosis Risk in Communities Study (ARIC): absolute and attributable risks of cardiovascular disease incidence in relation to optimal and borderline risk factors. Arch Intern Med. 2007;167:573–579
  22. Leosdottir M, Nilsson PM, Nilsson JA, Mansson H, Berglund G. Dietary fat intake and early mortality patterns: data from the Malmo Diet and Cancer Study. J Intern Med. 2005;258:153–165
  23. Hooper L, Summerbell CD, Higgins JPT, Thompson RL, Capps NE, Davey Smith G, et al. Dietary fat intake and prevention of cardiovascular disease: systematic review. BMJ. 2001;322:757–763
  24. Law M, Wald N, Rudnicka A. Quantifying effect of statins on low density lipoprotein cholesterol, ischemic heart disease, and stroke: systematic review and meta-analysis. BMJ. 2003;326:1423–1429
  25. Nichols A, Ravenscroft C, Lamphiear DE, Ostrander LD. Daily nutritional intake and serum lipid levels (Tecusemeh Study). Am J Clin Nutr. 1976;29:1384–1392
  26. Clarke R, Frost C, Collins R, Appleby P, Peto R. Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies. BMJ. 1997;413:112–117
  27. Law MR, Wald NJ, Thompson SG. By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease?. BMJ. 1994;308:367–372
  28. Mills EJ, Rachlis B, Wu P, Devereaux PJ, Arora P, Perri D. Primary prevention of cardiovascular mortality and events with statin treatments (A network meta-analysis involving more than 65000 patients). J Am Coll Cardiol. 2008;52:1769–1781
  29. Pletcher MJ, Lazar L, Bibbins-Domingo K, Moran A, Rodondo N, Coxson P, et al. Comparing impact and cost-effectiveness of primary prevention strategies for lipid-lowering. Ann Int Med. 2009;150:243–254
  30. Jacobson T. Statin safety: lessons from new drug applications for marketed statins. Am J Cardiol. 2006;97:S44–S51
  31. Baigent C, Keech A, Kearney PM, Blackwell L, Buck G, Pollicino C, et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90056 participants in 14 randomised trials of statins. Lancet. 2005;366:1267–1278
  32. Newman C, Tsai J, Szarek M, Luo D, Gibson E. Comparative safety of atorvastatin 80mg versus 10mg derived from analysis of 49 completed trials in 14,236 patients. Am J Cardiol. 2006;97:61–67
  33. Rasumssen JN, Chong A, Alter DA. Relationship between adherence to evidence-based pharmacotherapy and long-term mortality after acute myocardial infarction. JAMA. 2007;297:177–186
  34. Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM, Kastelein JJ, et al. Rosuvastatin to prevent vascular events in men and women with elevated CRP. N Engl J Med. 2008;359:2195–2207

 Dr. Francis is supported by grant FS 04/079 from the British Heart Foundation, London, United Kingdom.

 We have chosen the Quarter Pounder® because it is a product that is universally known and universally uniform in its characteristics. We use it, however, solely as a proxy for all foods of certain fat and trans-fat content. We do not suggest that a Quarter Pounder® poses any health threat greater than any other food with the same fat and trans-fat content.

PII: S0002-9149(10)00870-2

doi: 10.1016/j.amjcard.2010.03.077

American Journal of Cardiology
Volume 106, Issue 4 , Pages 587-592 , 15 August 2010

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