American Journal of Cardiology
Volume 105, Issue 6 , Pages 797-803 , 15 March 2010

Usefulness of Soluble Fas Levels for Improving Diagnostic Accuracy and Prognosis for Acute Coronary Syndromes

  • Héloise Cardinal, MD, MSc

      Affiliations

    • Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada
    • Division of Clinical Epidemiology, McGill University Health Centre, Montréal, Quebec, Canada
    • Corresponding Author InformationCorresponding author: Tel: (+1-514) 890-8000, extension 32588; fax: (+1-514) 412-7342
    • ,
  • James M. Brophy, MD, PhD

      Affiliations

    • Division of Clinical Epidemiology, McGill University Health Centre, Montréal, Quebec, Canada
    • Division of Cardiology, McGill University Health Centre, Montréal, Quebec, Canada
    • ,
  • Peter Bogaty, MD

      Affiliations

    • Quebec Heart Institute, Laval Hospital, Laval University, Quebec, Quebec, Canada
    • ,
  • Lawrence Joseph, PhD

      Affiliations

    • Division of Clinical Epidemiology, McGill University Health Centre, Montréal, Quebec, Canada
    • ,
  • Marie-Josée Hébert, MD

      Affiliations

    • Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada
    • ,
  • Luce Boyer

      Affiliations

    • Quebec Heart Institute, Laval Hospital, Laval University, Quebec, Quebec, Canada
    • ,
  • François Madore, MD, MSc

      Affiliations

    • Department of Medicine, Hôpital du Sacré-Coeur de Montréal, Montréal, Quebec, Canada

Received 24 September 2009 ,Revised 28 October 2009 ,Accepted 28 October 2009.

References 

  1. Newby LK, Christenson RH, Ohman EM, Armstrong PW, Thompson TD, Lee KL, et al. Value of serial troponin T measures for early and late risk stratification in patients with acute coronary syndromes (The GUSTO-IIa Investigators). Circulation. 1998;98:1853–1859
  2. Bogaty P, Boyer L, Simard S, Dauwe F, Dupuis R, Verret B, et al. Clinical utility of C-reactive protein measured at admission, hospital discharge, and 1 month later to predict outcome in patients with acute coronary disease: the RISCA (recurrence and inflammation in the acute coronary syndromes) study. J Am Coll Cardiol. 2008;51:2339–2346
  3. Wacholder S, Gail M, Pee D. Selecting an efficient design for assessing exposure-disease relationships in an assembled cohort. Biometrics. 1991;47:63–76
  4. National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002;39:S1–S266
  5. DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988;44:837–845
  6. Tanaka M, Ito H, Adachi S, Akimoto H, Nishikawa T, Kasajima T, et al. Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes. Circ Res. 1994;75:426–433
  7. Ruixing Y, Al-Ghazali R, Wenwu L, Jinzhen W. Pretreatment with probucol attenuates cardiomyocyte apoptosis in a rabbit model of ischemia/reperfusion. Scand J Clin Lab Invest. 2006;66:549–558
  8. Olivetti G, Quaini F, Sala R, Lagrasta C, Corradi D, Bonacina E, et al. Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart. J Mol Cell Cardiol. 1996;28:2005–2016
  9. Liu T, Laurell C, Selivanova G, Lundeberg J, Nilsson P, Wiman KG. Hypoxia induces p53-dependent transactivation and Fas/CD95-dependent apoptosis. Cell Death Differ. 2007;14:411–421
  10. Reeve JL, Szegezdi E, Logue SE, Chonghaile TN, O'Brien T, Ritter T, et al. Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-xL. J Cell Mol Med. 2007;11:509–520
  11. Cascino I, Fiucci G, Papoff G, Ruberti G. Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing. J Immunol. 1995;154:2706–2713
  12. Fiorina P, Astorri E, Albertini R, Secchi A, Mello A, Lanfredini M, et al. Soluble antiapoptotic molecules and immune activation in chronic heart failure and unstable angina pectoris. J Clin Immunol. 2000;20:101–106
  13. Zhang L, Zhang L, Li YH, Zhang HY, Chen ML, Gao MM, et al. High-dose glucose-insulin-potassium treatment reduces myocardial apoptosis in patients with acute myocardial infarction. Eur J Clin Invest. 2005;35:164–170
  14. Niessner A, Hohensinner PJ, Rychli K, Neuhold S, Zorn G, Richter B, et al. Prognostic value of apoptosis markers in advanced heart failure patients. Eur Heart J. 2009;30:789–796
  15. Guerra S, Leri A, Wang X, Finato N, Di Loreto C, Beltrami CA, et al. Myocyte death in the failing human heart is gender dependent. Circ Res. 1999;85:856–866
  16. Eagle KA, Lim MJ, Dabbous OH, Pieper KS, Goldberg RJ, Van de Werf F, et al. A validated prediction model for all forms of acute coronary syndrome: estimating the risk of 6-month postdischarge death in an international registry. JAMA. 2004;291:2727–2733
  17. Yan AT, Yan RT, Tan M, Casanova A, Labinaz M, Sridhar K, et al. Risk scores for risk stratification in acute coronary syndromes: useful but simpler is not necessarily better. Eur Heart J. 2007;28:1072–1078
  18. Morrow DA, Rifai N, Antman EM, Weiner DL, McCabe CH, Cannon CP, et al. C-reactive protein is a potent predictor of mortality independently of and in combination with troponin T in acute coronary syndromes: a TIMI 11A substudy (Thrombolysis In Myocardial Infarction). J Am Coll Cardiol. 1998;31:1460–1465
  19. Rebuzzi AG, Quaranta G, Liuzzo G, Caligiuri G, Lanza GA, Gallimore JR, et al. Incremental prognostic value of serum levels of troponin T and C-reactive protein on admission in patients with unstable angina pectoris. Am J Cardiol. 1998;82:715–719
  20. Lee Y, Gustafsson AB. Role of apoptosis in cardiovascular disease. Apoptosis. 2009;14:536–548
  21. Rossi ML, Marziliano N, Merlini PA, Bramucci E, Canosi U, Belli G, et al. Different quantitative apoptotic traits in coronary atherosclerotic plaques from patients with stable angina pectoris and acute coronary syndromes. Circulation. 2004;110:1767–1773
  22. Myoishi M, Hao H, Minamino T, Watanabe K, Nishihira K, Hatakeyama K, et al. Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome. Circulation. 2007;116:1226–1233
  23. Troyanov S, Hebert MJ, Masse M, Vigneault N, Sirois I, Madore F. Soluble Fas: a novel predictor of atherosclerosis in dialysis patients. Am J Kidney Dis. 2003;41:1043–1051
  24. Reichlin T, Hochholzer W, Bassetti S, Steuer S, Stelzig C, Hartwiger S, et al. Early diagnosis of myocardial infarction with sensitive cardiac troponin assays. N Engl J Med. 2009;361:858–867

 This project was supported by the Fonds de Recherche en Santé du Québec (clinical research subvention 6767). The Fonds de Recherche en Santé du Québec provided salarial support to Drs. Cardinal, Joseph, Brophy, and Madore. The RISCA study was financed by Dr. Bogaty, by the Fonds de la Recherche en Santé du Québec (FRSQ), the Heart and Stroke Foundation of Canada, and unrestricted grants from Pfizer, Canada, Kirkland, Quebec, and Merck Frosst Canada, Kirkland, Quebec, Canada.

PII: S0002-9149(09)02681-2

doi: 10.1016/j.amjcard.2009.10.061

American Journal of Cardiology
Volume 105, Issue 6 , Pages 797-803 , 15 March 2010

Article Tools

* Image Usage & Resolution