American Journal of Cardiology
Volume 105, Issue 6 , Pages 761-766 , 15 March 2010

Low-Density Lipoprotein and Noncalcified Coronary Plaque Composition in Patients With Newly Diagnosed Coronary Artery Disease on Computed Tomographic Angiography

  • Victor Y. Cheng, MD

      Affiliations

    • Departments of Internal Medicine and Imaging, Cedars-Sinai Medical Center, Los Angeles, California
    • Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California
    • Corresponding Author InformationCorresponding author: Tel: (310) 423-4223; fax: (310) 423-0081
  • ,
  • Arik Wolak, MD

      Affiliations

    • Departments of Internal Medicine and Imaging, Cedars-Sinai Medical Center, Los Angeles, California
  • ,
  • Ariel Gutstein, MD

      Affiliations

    • Departments of Internal Medicine and Imaging, Cedars-Sinai Medical Center, Los Angeles, California
  • ,
  • Heidi Gransar, MS

      Affiliations

    • Departments of Internal Medicine and Imaging, Cedars-Sinai Medical Center, Los Angeles, California
  • ,
  • Nathan D. Wong, PhD

      Affiliations

    • Heart Disease Prevention Program, Department of Medicine, University of California, Irvine, School of Medicine, Irvine, California
  • ,
  • Damini Dey, PhD

      Affiliations

    • Departments of Internal Medicine and Imaging, Cedars-Sinai Medical Center, Los Angeles, California
    • Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California
  • ,
  • Louise E.J. Thomson, MD

      Affiliations

    • Departments of Internal Medicine and Imaging, Cedars-Sinai Medical Center, Los Angeles, California
    • Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California
  • ,
  • Sean W. Hayes, MD

      Affiliations

    • Departments of Internal Medicine and Imaging, Cedars-Sinai Medical Center, Los Angeles, California
    • Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California
  • ,
  • John D. Friedman, MD, MPH

      Affiliations

    • Departments of Internal Medicine and Imaging, Cedars-Sinai Medical Center, Los Angeles, California
    • Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California
  • ,
  • Piotr J. Slomka, PhD

      Affiliations

    • Departments of Internal Medicine and Imaging, Cedars-Sinai Medical Center, Los Angeles, California
    • Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California
  • ,
  • Daniel S. Berman, MD

      Affiliations

    • Departments of Internal Medicine and Imaging, Cedars-Sinai Medical Center, Los Angeles, California
    • Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California

Received 13 August 2009 ,Revised 6 November 2009 ,Accepted 6 November 2009.

References 

  1. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20:1262–1275
  2. Virmani R, Burke AP, Farb A, Kolodgie FD. Pathology of the vulnerable plaque. J Am Coll Cardiol. 2006;47(Suppl):C13–C18
  3. Ehara S, Kobayashi Y, Yoshiyama M, Shimada K, Shimada Y, Fukuda D, et al. Spotty calcification typifies the culprit plaque in patients with acute myocardial infarction: an intravascular ultrasound study. Circulation. 2004;110:3424–3429
  4. Sano K, Kawasaki M, Ishihara Y, Okubo M, Tsuchiya K, Nishigaki K, et al. Assessment of vulnerable plaques causing acute coronary syndrome using integrated backscatter intravascular ultrasound. J Am Coll Cardiol. 2006;47:734–741
  5. Pundziute G, Schuijf JD, Jukema JW, Decramer I, Sarno G, Vanhoenacker PK, et al. Evaluation of plaque characteristics in acute coronary syndromes: non-invasive assessment with multi-slice computed tomography and invasive evaluation with intravascular ultrasound radiofrequency data analysis. Eur Heart J. 2008;29:2373–2381
  6. Hoffmann U, Moselewski F, Nieman K, Jang IK, Ferencik M, Rahman AM, et al. Noninvasive assessment of plaque morphology and composition in culprit and stable lesions in acute coronary syndrome and stable lesions in stable angina by multidetector computed tomography. J Am Coll Cardiol. 2006;47:1655–1662
  7. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA. 2001;285:2486–2497
  8. Nomura K, Yamanouchi T, Kim GU, Ohwaki K, Yano E. Impact of glucose intolerance on coronary calcified lesions evaluated using multislice computed tomography. Tohoku J Exp Med. 2007;212:107–113
  9. Bamberg F, Dannemann N, Shapiro MD, Seneviratne SK, Ferencik M, Butler J, et al. Association between cardiovascular risk profiles and the presence and extent of different types of coronary atherosclerotic plaque as detected by multidetector computed tomography. Arterioscler Thromb Vasc Biol. 2008;28:568–574
  10. Yun CH, Schlett CL, Rogers IS, Truong QA, Toepker M, Donnelly P, et al. Association between diabetes and different components of coronary atherosclerotic plaque burden as measured by coronary multidetector computed tomography. Atherosclerosis. 2009;205:481–485
  11. Arad Y, Newstein D, Cadet F, Roth M, Guerci AD. Association of multiple risk factors and insulin resistance with increased prevalence of asymptomatic coronary artery disease by an electron-beam computed tomographic study. Arterioscler Thromb Vasc Biol. 2001;21:2051–2058
  12. Taylor AJ, Feuerstein I, Wong H, Barko W, Brazaitis M, O'Malley PG. Do conventional risk factors predict subclinical coronary artery disease? (Results from the Prospective Army Coronary Calcium Project). Am Heart J. 2001;141:463–468
  13. Mackey RH, Kuller LH, Sutton-Tyrrell K, Evans RW, Holubkov R, Matthews KA. Lipoprotein subclasses and coronary artery calcium in postmenopausal women from the healthy women study. Am J Cardiol. 2002;90:71i–76i
  14. Hoff JA, Daviglus ML, Chomka EV, Krainik AJ, Sevrukov A, Kondos GT. Conventional coronary artery disease risk factors and coronary artery calcium detected by electron beam tomography in 30,908 healthy individuals. Ann Epidemiol. 2003;13:163–169
  15. Allison MA, Wright M, Tiefenbrun J. The predictive power of low-density lipoprotein cholesterol for coroanry calcification. Int J Cardiol. 2003;90:281–289
  16. Orakzai SH, Nasir K, Blaha M, Blumenthal RS, Raggi P. Non-HDL cholesterol is strongly associated with coronary artery calcification in asymptomatic individuals. Atherosclerosis. 2009;202:289–295
  17. Wentworth P, Nieva J, Takeuchi C, Galve R, Wentworth AD, Dilley RB, et al. Evidence for ozone formation in human atherosclerotic arteries. Science. 2003;302:1053–1056
  18. Libby P. Inflammation in atherosclerosis. Nature. 2002;420:868–874
  19. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352:1685–1695
  20. Motoyama S, Sarai M, Harigaya H, Anno H, Inoue K, Hara T, et al. Computed tomographic angiography characteristics of atherosclerotic plaques subsequently resulting in acute coronary syndrome. J Am Coll Cardiol. 2009;54:49–57
  21. Hecht HS, Harman SM. Relation of aggressiveness of lipid-lowering treatment to changes in calcified plaque burden by electron beam tomography. Am J Cardiol. 2003;92:334–336
  22. Raggi P, Callister TQ, Davidson M, Welty FK, Bachmann GA, Laskey R, et al. Aggressive versus moderate lipid-lowering therapy in hypercholesterolemic postmenopausal women: Beyond Endorsed Lipid Lowering with EBT Scanning (BELLES). Circulation. 2005;112:563–571
  23. Schmermund A, Achenbach S, Budde T, Buziashvili Y, Förster A, Friedrich G, et al. Effect of intensive versus standard lipid-lowering treatment with atorvastatin on the progression of calcified coronary atherosclerosis over 12 months: a multicenter, randomized, double-blind trial. Circulation. 2006;113:427–437
  24. Burgstahler C, Reimann A, Beck T, Kuettner A, Baumann D, Heuschmid M, et al. Influence of a lipid-lowering therapy on calcified and noncalcified coronary plaques monitored by multislice detector computed tomography: results of the new AgeII pilot study. Inves Radiol. 2007;42:189–195
  25. Pundziute G, Schuijf JD, Jukema JW, Boersma E, Scholte AJ, Kroft LJ, et al. Noninvasive assessment of plaque characteristics with multislice computed tomography coronary angiography in symptomatic diabetic patients. Diabetes Care. 2007;30:1113–1119
  26. Achenbach S, Moselewski F, Ropers D, Ferencik M, Hoffmann U, MacNeill B, et al. Detection of calcified and noncalcified coronary atherosclerotic plaque by contrast-enhanced, submillimeter multidetector spiral computed tomography: a segment-based comparison with intravascular ultrasound. Circulation. 2004;109:14–17
  27. Leber AW, Knez A, von Ziegler F, Becker A, Nikolaou K, Paul S, et al. Quantification of obstructive and nonobstructive coronary lesions by 64-slice computed tomography: a comparative study with quantitative coronary angiography and intravascular ultrasound. J Am Coll Cardiol. 2005;46:147–154
  28. Leber AW, Becker A, Knez A, von Ziegler F, Sirol M, Nikolaou K, et al. Accuracy of 64-slice computed tomography to classify and quantify plaque volumes in the proximal coronary system: a comparative study using intravascular ultrasound. J Am Coll Cardiol. 2006;47:672–677
  29. Otsuka M, Bruining N, Van Pelt NC, Mollet NR, Ligthart JM, Vourvouri E, et al. Quantification of coronary plaque by 64-slice computed tomography: A comparison with quantitative intracoronary ultrasound. Invest Radiol. 2008;43:314–321
  30. Hoffmann H, Frieler K, Hamm B, Dewey M. Intra- and interobserver variability in detection and assessment of calcified and noncalcified coronary artery plaques using 64-slice computed tomography: variability in coronary plaque measurement using MSCT. Int J Cardiovasc Imaging. 2008;24:735–742
  31. Pflederer T, Schmid M, Ropers D, Ropers U, Komatsu S, Daniel WG, et al. Interobserver variability of 64-slice computed tomography for the quantification of noncalcified coronary atherosclerotic plaque. Rofo. 2007;179:953–957

 This study was supported by a grant from the Lincy Foundation, Beverly Hills, California.

PII: S0002-9149(09)02676-9

doi: 10.1016/j.amjcard.2009.11.007

American Journal of Cardiology
Volume 105, Issue 6 , Pages 761-766 , 15 March 2010