Low-Density Lipoprotein and Noncalcified Coronary Plaque Composition in Patients With Newly Diagnosed Coronary Artery Disease on Computed Tomographic Angiography

Cheng, Victor Y.; Wolak, Arik; Gutstein, Ariel; Gransar, Heidi; Wong, Nathan D.; Dey, Damini; Thomson, Louise E.J.; Hayes, Sean W.; Friedman, John D.; Slomka, Piotr J.; Berman, Daniel S.

doi:10.1016/j.amjcard.2009.11.007

« Previous Next »American Journal of Cardiology
Volume 105, Issue 6 , Pages 761-766, 15 March 2010

Low-Density Lipoprotein and Noncalcified Coronary Plaque Composition in Patients With Newly Diagnosed Coronary Artery Disease on Computed Tomographic Angiography

Victor Y. Cheng, MD
- Departments of Internal Medicine and Imaging, Cedars-Sinai Medical Center, Los Angeles, California
- Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California
- Corresponding author: Tel: (310) 423-4223; fax: (310) 423-0081
Arik Wolak, MD
- Departments of Internal Medicine and Imaging, Cedars-Sinai Medical Center, Los Angeles, California
Ariel Gutstein, MD
- Departments of Internal Medicine and Imaging, Cedars-Sinai Medical Center, Los Angeles, California
Heidi Gransar, MS
- Departments of Internal Medicine and Imaging, Cedars-Sinai Medical Center, Los Angeles, California
Nathan D. Wong, PhD
- Heart Disease Prevention Program, Department of Medicine, University of California, Irvine, School of Medicine, Irvine, California
Damini Dey, PhD
- Departments of Internal Medicine and Imaging, Cedars-Sinai Medical Center, Los Angeles, California
- Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California
Louise E.J. Thomson, MD
- Departments of Internal Medicine and Imaging, Cedars-Sinai Medical Center, Los Angeles, California
- Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California
Sean W. Hayes, MD
- Departments of Internal Medicine and Imaging, Cedars-Sinai Medical Center, Los Angeles, California
- Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California
John D. Friedman, MD, MPH
- Departments of Internal Medicine and Imaging, Cedars-Sinai Medical Center, Los Angeles, California
- Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California
Piotr J. Slomka, PhD
- Departments of Internal Medicine and Imaging, Cedars-Sinai Medical Center, Los Angeles, California
- Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California
Daniel S. Berman, MD
- Departments of Internal Medicine and Imaging, Cedars-Sinai Medical Center, Los Angeles, California
- Department of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California

Received 13 August 2009; received in revised form 6 November 2009; accepted 6 November 2009. published online 08 February 2010.

We sought to determine significant relations between atherogenic lipoproteins and the contribution of calcified plaque (CP), mixed plaque (MP), and noncalcified plaque (NCP) to the total plaque (TP) burden in patients without previous coronary artery disease. From 823 adult patients without previously established coronary artery disease (52% receiving statin therapy, 34% asymptomatic) but with visible coronary plaque on coronary computed tomographic angiography, we obtained segmental CP, MP, NCP, and TP counts from contrast-enhanced, electrocardiographic-gated computed tomography. Multivariate linear regression analysis was used to determine the associations of clinical factors and lipoprotein levels to CP, MP, and NCP counts and CP/TP, MP/TP, and NCP/TP count ratios. Age, male gender, diabetes, smoking, and statin therapy were significantly associated with the CP count (p <0.001, p <0.001, p = 0.049, p = 0.016, and p = 0.003, respectively). Low-density lipoprotein (LDL) cholesterol was significantly associated with MP and NCP counts (all p values ≤0.002). LDL cholesterol was also the only variable to demonstrate significant concurrent relations with CP/TP, MP/TP, and NCP/TP ratios, including an inverse association with CP/TP (p = 0.008) and a positive association with MP/TP (p = 0.032). Analyses using non–high-density lipoprotein cholesterol in place of LDL cholesterol yielded similar results. In conclusion, among the traditional clinical factors used to estimate cardiovascular event risk, LDL cholesterol is associated with an increased MP and NCP burden and is the sole variable that independently predicted relative predominance of CP, MP, and NCP, suggesting a potentially important role for lipoprotein levels in modulating the type of detectable coronary arterial plaque.