American Journal of Cardiology
Volume 105, Issue 3 , Pages 411-416 , 1 February 2010

Relation of Effective Anticoagulation in Patients With Atrial Fibrillation to Stroke Severity and Survival (from the National Acute Stroke Israeli Survey [NASIS])

  • Yvonne Schwammenthal, MD

      Affiliations

    • Chaim Sheba Medical Center, Tel Aviv, Israel
    • Tel Aviv University Sackler Faculty of Medicine, Tel Aviv, Israel
    • ,
  • Natan Bornstein, MD

      Affiliations

    • Tel Aviv University Sackler Faculty of Medicine, Tel Aviv, Israel
    • Tel-Aviv Medical Center, Tel Aviv, Israel
    • ,
  • Ehud Schwammenthal, MD

      Affiliations

    • Chaim Sheba Medical Center, Tel Aviv, Israel
    • Tel Aviv University Sackler Faculty of Medicine, Tel Aviv, Israel
    • ,
  • Roseline Schwartz, MSc

      Affiliations

    • Chaim Sheba Medical Center, Tel Aviv, Israel
    • Tel Aviv University Sackler Faculty of Medicine, Tel Aviv, Israel
    • ,
  • Uri Goldbourt, PhD

      Affiliations

    • Tel Aviv University Sackler Faculty of Medicine, Tel Aviv, Israel
    • ,
  • Rakefet Tsabari, MD

      Affiliations

    • Chaim Sheba Medical Center, Tel Aviv, Israel
    • Tel Aviv University Sackler Faculty of Medicine, Tel Aviv, Israel
    • ,
  • Silvia Koton, PhD

      Affiliations

    • Center of Disease Control, Tel Aviv, Israel
    • ,
  • Ehud Grossman, MD

      Affiliations

    • Chaim Sheba Medical Center, Tel Aviv, Israel
    • Tel Aviv University Sackler Faculty of Medicine, Tel Aviv, Israel
    • ,
  • David Tanne, MD

      Affiliations

    • Chaim Sheba Medical Center, Tel Aviv, Israel
    • Tel Aviv University Sackler Faculty of Medicine, Tel Aviv, Israel
    • Corresponding Author InformationCorresponding author: Tel: (+972) 3-530-2069; fax: (+972) 3-635-6087

Received 30 June 2009 ,Revised 16 September 2009 ,Accepted 16 September 2009.

References 

  1. Go AS, Hylek EM, Phillips KA, Chang Y, Henault LE, Selby JV, et al. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) study. JAMA. 2001;285:2370–2375
  2. Lamassa M, Di Carlo A, Pracucci G, Basile AM, Trefoloni G, Vanni P, et al. Characteristics, outcome, and care of stroke associated with atrial fibrillation in Europe: data from a multicenter multinational hospital-based registry (the European Community Stroke Project). Stroke. 2001;32:392–398
  3. Saxena R, Koudstaal PJ. Anticoagulants for preventing stroke in patients with nonrheumatic atrial fibrillation and a history of stroke or transient ischaemic attack. Cochrane Database Syst Rev. 2004;CD000185
  4. Longstreth WT, Bernick C, Fitzpatrick A, Cushman M, Knepper L, Lima J, et al. Frequency and predictors of stroke death in 5,888 participants in the cardiovascular health study. Neurology. 2001;56:368–375
  5. Hart RG, Pearce LA, Miller VT, Anderson DC, Rothrock JF, Albers GW, et al. Cardioembolic vs. noncardioembolic strokes in atrial fibrillation: frequency and effect of antithrombotic agents in the stroke prevention in atrial fibrillation studies. Cerebrovasc Dis. 2000;10:39–43
  6. Sandercock P, Bamford J, Dennis M, Burn J, Slattery J, Jones L, et al. Atrial fibrillation and stroke: prevalence in different types of stroke and influence on early and long term prognosis (Oxfordshire Community Stroke Project). BMJ. 1992;305:1460–1465
  7. Lin HJ, Wolf PA, Kelly-Hayes M, Beiser AS, Kase CS, Benjamin EJ, et al. Stroke severity in atrial fibrillation: the Framingham study. Stroke. 1996;27:1760–1764
  8. Aguilar MI, Hart R, Pearce LA. Oral anticoagulants versus antiplatelet therapy for preventing stroke in patients with non-valvular atrial fibrillation and no history of stroke or transient ischemic attacks. Cochrane Database Syst Rev. 2007;CD006186
  9. Hart RG, Pearce LA, Aguilar MI. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med. 2007;146:857–867
  10. Fuster V, Ryden LE, Cannom DS, Crijns HJ, Curtis AB, Ellenbogen KA, et al. ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines; 2006 (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation. 2006;114:e257–e354
  11. Hylek EM, Go AS, Chang Y, Jensvold NG, Henault LE, Selby JV, et al. Effect of intensity of oral anticoagulation on stroke severity and mortality in atrial fibrillation. N Engl J Med. 2003;349:1019–1026
  12. O'Donnell M, Oczkowski W, Fang J, Kearon C, Silva J, Bradley C, et al. Preadmission antithrombotic treatment and stroke severity in patients with atrial fibrillation and acute ischaemic stroke: an observational study. Lancet Neurol. 2006;5:749–754
  13. Paciaroni M, Agnelli G, Caso V, Venti M, Alberti A, Milia P, et al. Prior use of antithrombotic agents and neurological functional outcome at discharge in patients with ischemic stroke. J Thromb Haemost. 2006;4:1957–1961
  14. Indredavik B, Rohweder G, Lydersen S. Frequency and effect of optimal anticoagulation before onset of ischaemic stroke in patients with known atrial fibrillation. J Intern Med. 2005;258:133–144
  15. Tanne D, Goldbourt U, Koton S, Grossman E, Koren-Morag N, Green MS, et al. A national survey of acute cerebrovascular disease in Israel: burden, management, outcome and adherence to guidelines. Isr Med Assoc J. 2006;8:3–7
  16. In:  Herndon R editors. Handbook of Neurologic Rating Scales. New York: Demos Vermande; 1997;
  17. Bamford J, Sandercock P, Dennis M, Burn J, Warlow C. Classification and natural history of clinically identifiable subtypes of cerebral infarction. Lancet. 1991;337:1521–1526
  18. Hajat C, Dundas R, Stewart JA, Lawrence E, Rudd AG, Howard R, et al. Cerebrovascular risk factors and stroke subtypes: differences between ethnic groups. Stroke. 2001;32:37–42
  19. Hohnloser SH, Pajitnev D, Pogue J, Healey JS, Pfeffer MA, Yusuf S, et al. Incidence of stroke in paroxysmal versus sustained atrial fibrillation in patients taking oral anticoagulation or combined antiplatelet therapy: an ACTIVE W substudy. J Am Coll Cardiol. 2007;50:2156–2161

PII: S0002-9149(09)02421-7

doi: 10.1016/j.amjcard.2009.09.050

American Journal of Cardiology
Volume 105, Issue 3 , Pages 411-416 , 1 February 2010

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