American Journal of Cardiology
Volume 105, Issue 3 , Pages 359-361 , 1 February 2010

Usefulness of Breast Arterial Calcium Detected on Mammography for Predicting Coronary Artery Disease or Cardiovascular Events in Women With Angina Pectoris and/or Positive Stress Tests

  • Neelima Penugonda, MD

      Affiliations

    • William Beaumont Hospital, Royal Oak, Michigan
    • ,
  • Scott S. Billecke, PhD

      Affiliations

    • William Beaumont Hospital, Royal Oak, Michigan
    • ,
  • Michael W. Yerkey, MD

      Affiliations

    • Rockwood Heart Center, Heart Institute of Spokane, Spokane, Washington
    • ,
  • Murray Rebner, MD

      Affiliations

    • William Beaumont Hospital, Royal Oak, Michigan
    • ,
  • Pamela A. Marcovitz, MD

      Affiliations

    • William Beaumont Hospital, Royal Oak, Michigan
    • Corresponding Author InformationCorresponding author: Tel: 248-898-0515; fax: 248-898-3127

Received 10 July 2009 ,Revised 20 September 2009 ,Accepted 20 September 2009.

References 

  1. Maas AH, van der Schouw YT, Atsma F, Beijerinck D, Deurenberg JJ, Mali WP, et al. Breast arterial calcifications are correlated with subsequent development of coronary artery calcifications, but their aetiology is predominantly different. Eur J Radiol. 2007;63:396–400
  2. Crystal P, Crystal E, Leor J, Friger M, Katzinovitch G, Strano S. Breast artery calcium on routine mammography as a potential marker for increased risk of cardiovascular disease. Am J Cardiol. 2000;86:216–217
  3. Iribarren C, Go AS, Tolstykh I, Sidney S, Johnston SC, Spring DB. Breast vascular calcification and risk of coronary heart disease, stroke, and heart failure. J Womens Health. 2004;13:381–392
  4. Rotter MA, Schnatz PF, Currier AA, O'Sullivan DM. Breast arterial calcifications (BACs) found on screening mammography and their association with cardiovascular disease. Menopause. 2008;15:276–281
  5. van Noord PA, Beijerinck D, Kemmeren JM, van der Graaf Y. Mammograms may convey more than breast cancer risk: breast arterial calcification and arterio-sclerotic related diseases in women of the DOM cohort. Eur J Cancer Prev. 1996;5:483–487
  6. Fiuza Ferreira EM, Szejnfeld J, Faintuch S. Correlation between intramammary arterial calcifications and CAD. Acad Radiol. 2007;14:144–150
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  12. Cetin M, Cetin R, Tamer N, Kelekci S. Breast arterial calcifications associated with diabetes and hypertension. J Diabetes Complications. 2004;18:363–366
  13. Kemmeren JM, Beijerinck D, van Noord PA, Banga JD, Deurenberg JJ, Pameijer FA, et al. Breast arterial calcifications: association with diabetes mellitus and cardiovascular mortality (Work in progress). Radiology. 1996;201:75–78
  14. Kemmeren JM, van Noord PA, Beijerinck D, Fracheboud J, Banga JD, van der Graaf Y. Arterial calcification found on breast cancer screening mammograms and cardiovascular mortality in women: the DOM project (Doorlopend Onderzoek Morbiditeit en Mortaliteit). Am J Epidemiol. 1998;147:333–341
  15. Maas AH, van der Schouw YT, Beijerinck D, Deurenberg JJ, Mali WP, van der Graaf Y. Arterial calcium on mammograms is not associated with inflammatory markers for heart disease risk. Heart. 2006;92:541–542
  16. Maas AH, van der Schouw YT, Beijerinck D, Deurenberg JJ, Mali WP, van der Graaf Y. Arterial calcifications seen on mammograms: cardiovascular risk factors, pregnancy, and lactation. Radiology. 2006;240:33–38
  17. Sickles EA, Galvin HB. Breast arterial calcification in association with diabetes mellitus: too weak a correlation to have clinical utility. Radiology. 1985;155:577–579
  18. Kataoka M, Warren R, Luben R, Camus J, Denton E, Sala E, et al. How predictive is breast arterial calcification of cardiovascular disease and risk factors when found at screening mammography?. AJR Am J Roentgenol. 2006;187:73–80
  19. Maas AH, van der Schouw YT, Mali WP, van der Graaf Y. Prevalence and determinants of breast arterial calcium in women at high risk of cardiovascular disease. Am J Cardiol. 2004;94:655–659

 This study was supported by the Ministrelli Women's Heart Center, William Beaumont Hospital, Royal Oak, Michigan.

PII: S0002-9149(09)02410-2

doi: 10.1016/j.amjcard.2009.09.039

American Journal of Cardiology
Volume 105, Issue 3 , Pages 359-361 , 1 February 2010

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