American Journal of Cardiology
Volume 105, Issue 2 , Pages 198-204 , 15 January 2010

Tolerability of Red Yeast Rice (2,400 mg Twice Daily) Versus Pravastatin (20 mg Twice Daily) in Patients With Previous Statin Intolerance

  • Steven C. Halbert, MD

      Affiliations

    • Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • Jefferson-Myrna Brind Center for Integrative Medicine, Philadelphia, Pennsylvania
    • ,
  • Benjamin French, PhD

      Affiliations

    • Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Ram Y. Gordon, MD

      Affiliations

    • Division of Cardiology, Chestnut Hill Hospital, University of Pennsylvania Health System, Philadelphia, Pennsylvania
    • ,
  • John T. Farrar, MD

      Affiliations

    • Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Kathryn Schmitz, PhD

      Affiliations

    • Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • Patti B. Morris, RD

      Affiliations

    • Division of Cardiology, Chestnut Hill Hospital, University of Pennsylvania Health System, Philadelphia, Pennsylvania
    • ,
  • Paul D. Thompson, MD

      Affiliations

    • Division of Cardiology, Hartford Hospital, Hartford, Connecticut
    • ,
  • Daniel J. Rader, MD

      Affiliations

    • Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • David J. Becker, MD

      Affiliations

    • Division of Cardiology, Chestnut Hill Hospital, University of Pennsylvania Health System, Philadelphia, Pennsylvania
    • Corresponding Author InformationCorresponding author: Tel: (215) 233-9700; fax: (215) 233-9710

Received 18 June 2009 ,Revised 25 August 2009 ,Accepted 25 August 2009.

  • Image Result

    Participant flow through study. *Primary end point. †Those with missing data were included in analysis of primary outcome. MI = myocardial infarction; MVA = motor vehicle accident; SAM = statin-associ

    Participant flow through study. *Primary end point. †Those with missing data were included in analysis of primary outcome. MI = myocardial infarction; MVA = motor vehicle accident; SAM = statin-associated myalgia; TLC = therapeutic lifestyle program.

  • Image Result
    Individual maximum pain severity scores (solid lines) and average trend (dashed line) during study period for each treatment group. Individual trajectories and average trend plots were obtained using

    Individual maximum pain severity scores (solid lines) and average trend (dashed line) during study period for each treatment group. Individual trajectories and average trend plots were obtained using scatterplot smoother.

  • Image Result
    Point estimates and 95% CIs for mean muscle strength and mean LDL cholesterol for pravastatin group (white) and red yeast rice group (black).

    Point estimates and 95% CIs for mean muscle strength and mean LDL cholesterol for pravastatin group (white) and red yeast rice group (black).

 This study was supported by an unrestricted grant from the Commonwealth of Pennsylvania, and Chestnut Hill Health System, Philadelphia, Pennsylvania. Dr. Halbert was supported by grant T32AT000600 from the National Center for Complementary and Alternative Medicine, Bethesda, Maryland, and grant T32AG000253 from the National Institute on Aging, Bethesda, Maryland.

PII: S0002-9149(09)02325-X

doi: 10.1016/j.amjcard.2009.08.672

American Journal of Cardiology
Volume 105, Issue 2 , Pages 198-204 , 15 January 2010

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