American Journal of Cardiology
Volume 105, Issue 2 , Pages 174-178 , 15 January 2010

Impact of Acute Coronary Syndromes on Two-Year Clinical Outcomes in Patients With Unprotected Left Main Coronary Artery Stenosis Treated With Drug-Eluting Stents

  • Tullio Palmerini, MD

      Affiliations

    • Istituto di Cardiologia, Policlinico S. Orsola, Università di Bologna, Bologna, Italy
    • Corresponding Author InformationCorresponding author: Tel: 0039-051-349858; fax: 0039-051-344859
    • ,
  • Diego Sangiorgi, MSc

      Affiliations

    • Istituto di Cardiologia, Policlinico S. Orsola, Università di Bologna, Bologna, Italy
    • ,
  • Antonio Marzocchi, MD

      Affiliations

    • Istituto di Cardiologia, Policlinico S. Orsola, Università di Bologna, Bologna, Italy
    • ,
  • Corrado Tamburino, MD

      Affiliations

    • Dipartimento di Cardiologia, Ospedale Ferrarotto, Università di Catania, Catania, Italy
    • ,
  • Imad Sheiban, MD

      Affiliations

    • Divisione di Cardiologia, Università di Torino, Turin, Italy
    • ,
  • Massimo Margheri, MD

      Affiliations

    • Dipartimento Cardiovascolare, Ospedale Careggi, Università di Firenze, Florence, Italy
    • ,
  • Giuseppe Vecchi, MD

      Affiliations

    • Dipartimento di Cardiologia, Ospedale S. Maria delle Croci, Ravenna, Italy
    • ,
  • Giuseppe Sangiorgi, MD

      Affiliations

    • Centro Emocolumbus, Milan, Italy
    • ,
  • Nicoletta Franco, MD

      Affiliations

    • Dipartimento di Cardiologia, Ospedale degli Infermi, Rimini, Italy
    • ,
  • Antonio Bartorelli, MD

      Affiliations

    • Centro Cardiologico Monzino, Milan, Italy
    • ,
  • Carlo Briguori, MD, PhD

      Affiliations

    • Dipartimento di Cardiologia, Clinica Mediterranea, Naples, Italy
    • ,
  • Luigi Vignali, MD

      Affiliations

    • Unità Operativa di Cardiologia, Azienda Ospedaliero-Universitaria, Parma, Italy
    • ,
  • Francesco Di Pede, MD

      Affiliations

    • Dipartimento di Cardiologia, Azienda Ospedaliera, Mestre, Italy
    • ,
  • Angelo Ramondo, MD

      Affiliations

    • Dipartimento di Scienze Cardiovascolari, Università di Padova, Padua, Italy
    • ,
  • Massimo Medda, MD

      Affiliations

    • Cardiovascular Interventional Radiology Department, IRCCS Policlinico S. Donato, S. Donato Milanese, Milan, Italy
    • ,
  • Marco De Carlo, MD

      Affiliations

    • Dipartimento Cardio-Toracico, Ospedale Cisanello, Pisa, Italy
    • ,
  • Leonardo Bolognese, MD

      Affiliations

    • Dipartimento Cardiovascolare, Ospedale S. Donato, Arezzo, Italy
    • ,
  • Alberto Benassi, MD

      Affiliations

    • Dipartimento di Cardiologia, Hesperia Hospital, Modena, Italy
    • ,
  • Cataldo Palmieri, MD

      Affiliations

    • Istituto Fisiologia Clinica, CNR, Massa, Italy
    • ,
  • Vincenzo Filippone, MD

      Affiliations

    • Dipartimento Cardiovascolare, Ospedale Cervello, Palermo, Italy
    • ,
  • Giulia Lauria, MD

      Affiliations

    • Istituto di Cardiologia, Policlinico S. Orsola, Università di Bologna, Bologna, Italy
    • ,
  • Stefano De Servi, MD

      Affiliations

    • Dipartimento di Malattie Cardiovascolari, Ospedale Civile, Legnano, Italy

Received 14 July 2009 ,Revised 25 August 2009 ,Accepted 25 August 2009.

References 

  1. Palmerini T, Marzocchi A, Tamburino C, Sheiban I, Margheri M, Vecchi G, et al. Two-year clinical outcome with drug-eluting stents versus bare-metal stents in a real-world registry of unprotected left main coronary artery stenosis from the Italian Society of Invasive Cardiology. Am J Cardiol. 2008;102:1463–1468
  2. Palmerini T, Marzocchi A, Tamburino C, Sheiban I, Margheri M, Vecchi G, et al. Impact of bifurcation technique on 2-year clinical outcomes in 773 patients with distal unprotected left main coronary artery stenosis treated with drug eluting stents. Circ Cardiovasc Interv. 2008;1:185–192
  3. Nashef SA, Roques F, Michel P, Gauducheau E, Lemeshow S, Salamon R. European system for cardiac operative risk evaluation (EuroSCORE). Eur J Cardiothorac Surg. 1999;16:9–13
  4. Smith SC, Feldman TE, Hirshfeld JW, Jacobs AK, Kern MJ, King SB, et al. ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/SCAI writing committee to update 2001 guidelines for percutaneous coronary intervention). Circulation. 2005;2006(suppl):e166–e286
  5. Mehta SR, Yusuf S, Peters RJ, Bertrand ME, Lewis BS, Natarajan MK, et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet. 2001;358:527–533
  6. Steinhubl SR, Berger PB, Mann JT, Fry ET, DeLago A, Wilmer C, et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA. 2002;288:2411–2420
  7. Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, Alfonso F, Macaya C, Bass TA, et al. Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectives. J Am Coll Cardiol. 2007;49:1505–1516
  8. Cattaneo M. Resistance to antiplatelet drugs: molecular mechanisms and laboratory detection. J Thromb Haemost. 2007;5(suppl 1):230–237
  9. Gurbel PA, Bliden KP, Hiatt BL, O'Connor CM. Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation. 2003;107:2908–2913
  10. Buonamici P, Marcucci R, Migliorini A, Gensini GF, Santini A, Paniccia R, et al. Impact of platelet reactivity after clopidogrel administration on drug-eluting stent thrombosis. J Am Coll Cardiol. 2007;49:2312–2317
  11. Matetzky S, Shenkman B, Guetta V, Shechter M, Bienart R, Goldenberg I, et al. Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction. Circulation. 2004;109:3171–3175
  12. Wiviott SD, Trenk D, Frelinger AL, O'Donoghue M, Neumann FJ, Michelson AD, et al. Prasugrel compared with high loading- and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: the Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation–Thrombolysis In Myocardial Infarction 44 trial. Circulation. 2007;116:2923–2932
  13. Wiviott SD, Braunwald E, McCabe CH, Montalescot G, Ruzyllo W, Gottlieb S, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2007;357:2001–2015

PII: S0002-9149(09)02310-8

doi: 10.1016/j.amjcard.2009.08.666

American Journal of Cardiology
Volume 105, Issue 2 , Pages 174-178 , 15 January 2010

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