American Journal of Cardiology
Volume 105, Issue 1 , Pages 90-94 , 1 January 2010

Effect of Sinus Rhythm Restoration After Electrical Cardioversion on Apelin and Brain Natriuretic Peptide Prohormone Levels in Patients With Persistent Atrial Fibrillation

  • Eleftherios M. Kallergis, MD

      Affiliations

    • Department of Cardiology, University Hospital of Heraklion, Heraklion, Crete, Greece
    • Corresponding Author InformationCorresponding author: Tel: 302-810-392-877; fax: 302-810-542-055
    • ,
  • Emmanuel G. Manios, MD

      Affiliations

    • Department of Cardiology, University Hospital of Heraklion, Heraklion, Crete, Greece
    • ,
  • Emmanuel M. Kanoupakis, MD

      Affiliations

    • Department of Cardiology, University Hospital of Heraklion, Heraklion, Crete, Greece
    • ,
  • Hercules E. Mavrakis, MD

      Affiliations

    • Department of Cardiology, University Hospital of Heraklion, Heraklion, Crete, Greece
    • ,
  • Christos A. Goudis, MD

      Affiliations

    • Department of Cardiology, University Hospital of Heraklion, Heraklion, Crete, Greece
    • ,
  • Niki E. Maliaraki, MD

      Affiliations

    • Laboratory of Biochemistry, University Hospital of Heraklion, Heraklion, Crete, Greece
    • ,
  • Ilias G. Saloustros, MD

      Affiliations

    • Department of Cardiology, University Hospital of Heraklion, Heraklion, Crete, Greece
    • ,
  • Maria E. Milathianaki, PhD

      Affiliations

    • Laboratory of Biochemistry, University Hospital of Heraklion, Heraklion, Crete, Greece
    • ,
  • Gregory I. Chlouverakis, PhD

      Affiliations

    • Biostatistics Laboratory, University Hospital of Heraklion, Heraklion, Crete, Greece
    • ,
  • Panos E. Vardas, MD, PhD

      Affiliations

    • Department of Cardiology, University Hospital of Heraklion, Heraklion, Crete, Greece

Received 2 July 2009 ,Revised 4 August 2009 ,Accepted 4 August 2009.

References 

  1. Nattel S, Burstein B, Dobrev D. Atrial remodeling and atrial fibrillation (Mechanisms and implications). Circ Arrhythmia Electrophysiol. 2008;1:62–73
  2. Allessie M, Ausma J, Schotten U. Electrical, contractile and structural remodeling during atrial fibrillation. Cardiovasc Res. 2002;54:230–246
  3. Casaclang-Verzosa G, Gersh B, Tsang T. Structural and functional remodeling of the left atrium clinical and therapeutic implications for atrial fibrillation. J Am Coll Cardiol. 2008;51:1–11
  4. Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998;251:471–476
  5. Farkasfalvi K, Stagg MA, Coppen SR, Siedlecka U, Lee J, Soppa GK, et al. Direct effects of apelin on cardiomyocyte contractility and electrophysiology. Biochem Biophys Res Commun. 2007;357:889–895
  6. Ellinor PT, Low AF, Macrae CA. Reduced apelin levels in lone atrial fibrillation. Eur Heart J. 2006;27:222–226
  7. Lammers WJEP, Schalij MJ, Kirchhof CJHJ, Allessie MA. Quantification of spatial inhomogeneity in conduction and initiation of reentrant atrial arrhythmias. Am J Physiol Heart Circ Physiol. 1990;259:H1254–H1263
  8. Goetze JP, Friis-Hansen L, Rehfeld JF, Nilsson B, Svendsen JH. Atrial secretion of B-type natriuretic peptide. Eur Heart J. 2006;27:1648–1450
  9. Tveit A, Seljeflot I, Grundvold I, Abdelnoor M, Arnesen H, Smith P. Candesartan, NT-proBNP and recurrence of atrial fibrillation after electrical cardioversion. Int J Cardiol. 2009;131:234–239
  10. Japp AG, Newby DE. The apelin-APJ system in heart failure: pathophysiologic relevance and therapeutic potential. Biochem Pharmacol. 2008;75:1882–1892
  11. Chong KS, Gardner RS, Morton JJ, Ashley EA, McDonagh TA. Plasma concentrations of the novel peptide apelin are decreased in patients with chronic heart failure. Eur J Heart Fail. 2006;8:355–360
  12. Chen MM, Ashley EA, Deng DX, Tsalenko A, Deng A, Tabibiazar R, et al. Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction. Circulation. 2003;108:1432–1439
  13. Francia P, Salvati A, Balla C, De Paolis P, Pagannone E, Borro M, et al. Cardiac resynchronization therapy increases plasma levels of the endogenous inotrope apelin. Eur J Heart Fail. 2007;9:306–309

PII: S0002-9149(09)02221-8

doi: 10.1016/j.amjcard.2009.08.656

American Journal of Cardiology
Volume 105, Issue 1 , Pages 90-94 , 1 January 2010

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