American Journal of Cardiology
Volume 105, Issue 1 , Pages 54-58 , 1 January 2010

Effect of Quinapril on In-Stent Restenosis and Relation to Plasma Apoptosis Signaling Molecules

  • Spyridon Deftereos, MD

      Affiliations

    • Department of Cardiology, Athens General Hospital, Athens, Greece
    • ,
  • Georgios Giannopoulos, MD

      Affiliations

    • Department of Cardiology, Athens General Hospital, Athens, Greece
    • ,
  • Charalampos Kossyvakis, MD

      Affiliations

    • Department of Cardiology, Athens General Hospital, Athens, Greece
    • ,
  • Andreas Kaoukis, MD

      Affiliations

    • Department of Cardiology, Athens General Hospital, Athens, Greece
    • ,
  • Konstantin Raisakis, MD

      Affiliations

    • Department of Cardiology, Athens General Hospital, Athens, Greece
    • ,
  • Metaxia Driva, MD

      Affiliations

    • Department of Cardiology, Athens General Hospital, Athens, Greece
    • ,
  • Vasiliki Panagopoulou, MD

      Affiliations

    • Department of Cardiology, Athens General Hospital, Athens, Greece
    • ,
  • Spyridon Lappos, MD

      Affiliations

    • Department of Cardiology, Athens General Hospital, Athens, Greece
    • ,
  • Ilias Rentoukas, MD

      Affiliations

    • Department of Cardiology, A. Fleming General Hospital, Melissia, Greece
    • ,
  • Vlasios Pyrgakis, MD

      Affiliations

    • Department of Cardiology, Athens General Hospital, Athens, Greece
    • ,
  • Martin A. Alpert, MD

      Affiliations

    • Division of Cardiology, University of Missouri–Columbia School of Medicine, Columbia, Missouri
    • Corresponding Author InformationCorresponding author: Tel: 573-882-2296; fax: 573-884-7743

Received 2 May 2009 ,Revised 11 August 2009 ,Accepted 11 August 2009.

References 

  1. Hoffman R, Mintz GS, Dussaillant GR, Popma JJ, Pichard AD, Satler LF, et al. Patterns and mechanisms of in-stent restenosis: a serial intravascular ultrasound study. Circulation. 1996;94:1247–1254
  2. Cai W, Devaux B, Schaper W, Schaper J. The role of Fas/APO-1 and apoptosis in the development of human atherosclerotic lesions. Atherosclerosis. 1997;131:177–186
  3. Jiang C, Yang YF, Cheng SH. Fas ligand gene therapy for vascular intimal hyperplasia. Curr Gene Ther. 2004;4:33–39
  4. Holm AM, Andersen CB, Haunso S, Hansen PR. ACE-inhibition promotes apoptosis after balloon injury of rat carotid arteries. Cardivasc Res. 2000;45:777–782
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  10. Powell JS, Clozel JP, Muller RK, Kuhn H, Hefti F, Hosang M, et al. Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury. Science. 1989;245:186–188
  11. Ellis SG, Lincoff AM, Whitlow PL, Raymond RE, Franco I, Schneider JP, et al. Evidence that angiotensin-converting enzyme inhibitor use diminishes the need for coronary revascularization after stenting. Am J Cardiol. 2002;89:937–490
  12. Kondo J, Sone T, Tsuboi H, Mukawa H, Kosokabe T, Tsuzuki M, et al. Effect of quinapril on intimal hyperplasia after coronary stenting as assessed by intravascular ultrasound. Am J Cardiol. 2001;87:443–445
  13. Okumura K, Sone T, Kondo J, Tsuboi H, Mukawa H, Tsuzuki M, et al. Quinapril prevents restenosis after coronary stenting in patients with angiotensin-converting enzyme D allele. Circ J. 2002;66:311–316
  14. Maurice T, Bauters C, Hermant X, Codron V, VanBelle E, McFadden E, et al. Effect of ACE inhibitors on angiographic restenosis after coronary stenting (PARIS): a randomized, double-blind, placebo controlled trial. Lancet. 2001;357:1321–1324
  15. Jorgensen E, Kelbaek H, Helqvist S, Jensen GVH, Saunamaki K, Kastrup J, et al. Predictors of coronary in-stent restenosis: importance of angiotensin-converting enzyme gene polymorphism and treatment with angiotensin-converting enzyme inhibitors. J Am Coll Cardiol. 2001;38:1434–1439
  16. Cashin-Hemphill L, Holmvang G, Chan RC, Pitt B, Dinsmore RE, Lees RS QUIET Investigators. Angiotensin-converting enzyme inhibition as antiatherosclerotic therapy: no answer yet. Am J Cardiol. 1999;83:43–47
  17. Peters S, Gotting B, Trammel M, Rust H, Brattstrom A. Valsartan for Prevention of Restenosis After Stenting of Type B2/C Lesions: the VAL-PREST trial. J Invas Cardiol. 2001;13:93–97
  18. deBois D, Tea BS, Dam TV, Tremblay J, Hamet P. Smooth muscle apoptosis during vascular regression in spontaneously hypertensive rats. Hypertension. 1997;29:340–349

PII: S0002-9149(09)02213-9

doi: 10.1016/j.amjcard.2009.08.648

American Journal of Cardiology
Volume 105, Issue 1 , Pages 54-58 , 1 January 2010

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